Opportunity Information: Apply for RFA HD 10 003

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network (U10)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Jan 29, 2010 and posted on Jan 29, 2010.
  • Applicants must submit their applications by Jun 1, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $5,600,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH), issued this funding opportunity to support participation in the NICHD Cooperative Multicenter Neonatal Research Network through a U10 cooperative agreement. The central aim is to maintain and expand a coordinated, multi-center clinical research program focused on high-priority problems in neonatal medicine, with particular emphasis on low birth weight and prematurity, as well as other common medical conditions affecting newborns. In practical terms, the opportunity is meant for institutions and investigators who can function as clinical sites within an established network and work collaboratively with NICHD and other network members to design and conduct rigorous, multi-site clinical studies in neonatology.

The award uses the NIH U10 mechanism, which is a cooperative agreement rather than a traditional investigator-initiated research grant. That distinction matters because the U10 structure is built around substantial scientific and programmatic involvement from NIH staff. Instead of operating fully independently, funded sites are expected to partner closely with NICHD and the network infrastructure, follow common protocols, and contribute to network-wide research priorities. This kind of mechanism is typically used when a program requires consistent methods across multiple hospitals or centers, centralized coordination, shared data systems, and joint decision-making to successfully carry out large clinical trials or prospective studies in vulnerable populations like premature and low birth weight infants.

For funding, NICHD anticipated committing about $5.6 million in total costs in fiscal year 2011 to support up to 18 awards, which could include both new awards and competing continuation grants. The listed award ceiling is $200,000. In addition to site-level support, the announcement notes that protocol-related expenses would be allocated through the network’s data coordinating center, reflecting the network model in which certain shared study costs and coordinating activities are handled centrally rather than duplicated at each participating site.

Eligibility is broad and includes a mix of academic, nonprofit, for-profit (other than small business), and public institutions. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (with the non-501(c)(3) category explicitly noted as eligible), and for-profit organizations other than small businesses. The announcement also highlights additional eligible applicant types such as faith-based or community-based organizations, eligible federal agencies, and institutions that serve specific populations, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and related organizations. There is no cost sharing or matching requirement, which reduces barriers for institutions that might otherwise struggle to commit non-federal funds.

Administratively, the opportunity is categorized as discretionary funding and falls under the health-related CFDA listing 93.865 (Child Health and Human Development Extramural Research). The funding opportunity number is RFA-HD-10-003, and it was posted on January 29, 2010, with an application closing date of June 1, 2010 (it later archived on July 2, 2010). The full announcement was made available through the NIH grants guide, and the notice provides NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues, indicating this was a standard NIH electronic posting with centralized support for technical problems.

Overall, this grant opportunity is best understood as support for institutions that can contribute meaningfully to a standing neonatal research network: enrolling and caring for neonatal participants under shared protocols, collaborating across multiple centers, and working in a structured partnership with NICHD. The program’s focus on prematurity, low birth weight, and common neonatal conditions reflects NICHD’s priority on improving outcomes in early life through coordinated, multi-center clinical research that is difficult to accomplish at a single institution acting alone.

Frequently Asked Questions (FAQs)

What is this funding opportunity?

This is an NICHD (NIH) funding opportunity to support participation as a clinical site in the NICHD Cooperative Multicenter Neonatal Research Network using a U10 cooperative agreement mechanism.

Which NIH Institute is offering this opportunity?

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which is part of the National Institutes of Health (NIH).

What is the main purpose of the award?

The purpose is to maintain and expand a coordinated, multi-center clinical research program that addresses high-priority problems in neonatal medicine through a standing network of collaborating clinical sites.

What research areas or populations are emphasized?

The network focuses particularly on low birth weight and prematurity, and also targets other common medical conditions affecting newborns.

Who is this opportunity intended for?

It is intended for institutions and investigators that can function as clinical sites within an established multicenter network, enrolling and caring for neonatal participants under shared protocols and collaborating with NICHD and other network members on multi-site clinical studies.

What is the funding mechanism and why does it matter?

The award uses the NIH U10 mechanism, which is a cooperative agreement. This matters because it includes substantial scientific and programmatic involvement from NIH staff, and funded sites are expected to work in a coordinated partnership with NICHD and the network rather than operating fully independently.

How is a U10 cooperative agreement different from a traditional research grant?

Under a U10, NICHD staff have substantial involvement, and participating sites are expected to follow common protocols, use shared infrastructure, and contribute to network-wide priorities and joint decision-making. This differs from traditional investigator-initiated grants where the funded project typically operates more independently.

What kinds of activities are funded sites expected to do?

Funded sites are expected to collaborate with NICHD and other network members to design and conduct rigorous multi-site clinical studies in neonatology, using consistent methods across centers and working within shared network systems and processes.

Why is a network model being used for this program?

This approach supports consistent methods across multiple hospitals or centers, centralized coordination, shared data systems, and joint decision-making needed for large clinical trials or prospective studies in vulnerable neonatal populations such as premature and low birth weight infants.

How much funding was anticipated for this program?

NICHD anticipated committing about $5.6 million in total costs in fiscal year 2011 to support up to 18 awards (including both new awards and competing continuation grants).

What is the maximum award amount listed?

The listed award ceiling is $200,000.

How many awards were expected?

Up to 18 awards were anticipated, which could include both new awards and competing continuation awards.

Are protocol-related study expenses included in the site award budget?

The announcement indicates that protocol-related expenses would be allocated through the network's data coordinating center, reflecting that certain shared study costs and coordinating activities are handled centrally rather than duplicated at each site.

What types of organizations are eligible to apply?

Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), and for-profit organizations other than small businesses. The opportunity also notes eligibility for faith-based or community-based organizations, eligible federal agencies, and institutions serving specific populations.

Are for-profit organizations eligible?

Yes. For-profit organizations are eligible as long as they are not small businesses (the opportunity specifies "for-profit organizations other than small business").

Are nonprofit organizations without 501(c)(3) status eligible?

Yes. The eligibility list explicitly includes nonprofits without 501(c)(3) status.

Are institutions that serve specific populations highlighted as eligible?

Yes. The announcement highlights several categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and related organizations.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

How is this opportunity categorized administratively?

It is categorized as discretionary funding and is associated with CFDA 93.865 (Child Health and Human Development Extramural Research).

What is the funding opportunity number?

The funding opportunity number is RFA-HD-10-003.

When was the opportunity posted and when was the application due?

It was posted on January 29, 2010, and the application closing date was June 1, 2010.

Has the opportunity been archived?

Yes. The record indicates it was archived on July 2, 2010.

Where was the full announcement made available?

The full announcement was made available through the NIH grants guide.

Who should applicants contact for technical issues accessing or linking to the announcement?

The notice references NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues, consistent with standard NIH electronic posting support.

What is the overall goal for NICHD in offering this opportunity?

The overall goal is to improve outcomes in early life by supporting coordinated, multicenter clinical research in neonatology that is difficult to accomplish at a single institution acting alone, with a strong emphasis on prematurity, low birth weight, and other common neonatal conditions.

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