Opportunity Information: Apply for RFA PS 16 003
Apply for RFA PS 16 003
- The HHS-CDC-HHSCDCERA in the health sector is offering a public funding opportunity titled "Evaluating Locally-Developed or Adapted (Homegrown) Combination HIV Prevention Interventions for Transgender Persons who have Sex with Men" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.941.
- This funding opportunity was created on Nov 30, 2015 and posted on Nov 30, 2015.
- Applicants must submit their applications by Feb 12, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity, titled "Evaluating Locally-Developed or Adapted (Homegrown) Combination HIV Prevention Interventions for Transgender Persons who have Sex with Men" (Funding Opportunity Number RFA PS 16 003), is a CDC discretionary funding initiative offered through a cooperative agreement. Its central purpose is to strengthen the evidence base for HIV-related programs serving transgender people who have sex with men by funding rigorous evaluations of interventions that are already being used in real communities but have not yet been evaluated strongly enough to meet CDC standards for evidence.
The program focuses specifically on "combination" HIV prevention interventions, meaning approaches that do not rely on a single service or message. Instead, the interventions being evaluated are expected to integrate multiple components such as HIV prevention strategies, HIV care and treatment services, and additional social or structural supports that address barriers to health. In practical terms, this could include linkages to testing and prevention tools (such as PrEP navigation where relevant), support for engagement in HIV medical care for those living with HIV, adherence support, and wraparound services that reduce real-world obstacles like stigma, discrimination, unstable housing, limited access to affirming care, legal or documentation issues, and other social determinants that can increase HIV vulnerability or disrupt sustained treatment.
A defining requirement is that the interventions must be "homegrown," meaning they were locally developed or locally adapted either by the applicant organization itself or by a partnering community-based organization (CBO), community health center (CHC), or community service organization (CSO). The intent is to elevate promising, community-rooted models that may be working well locally but have not been studied in a way that produces broadly credible evidence. Rather than funding the invention of entirely new programs, the opportunity is designed to test and document the effectiveness of interventions that are already in place or have been adapted to fit local cultural and service contexts.
Applicants are allowed to evaluate a homegrown intervention focused on either transgender persons who are HIV-negative but at risk for infection or transgender persons living with HIV. This flexibility recognizes that combination approaches can operate across the prevention-to-care continuum. For HIV-uninfected participants, evaluations would typically examine outcomes tied to prevention uptake and sustained risk reduction, while for participants living with HIV, the emphasis would generally be on outcomes such as linkage to care, retention in care, medication adherence support, and progress along the HIV care continuum. Regardless of the population selected, the application must present an evaluation plan that aligns with CDC-published criteria for evidence, signaling that CDC expects methodologically sound designs, clear outcome measures, and credible analytic approaches capable of showing whether the intervention is effective.
In terms of funding structure and scale, the opportunity is administered by HHS/CDC (Agency: HHS-CDC-HHSCDCERA) and uses the cooperative agreement mechanism, which typically means the CDC anticipates an active partnership role with recipients (for example, providing technical guidance, expectations for reporting, and collaboration on evaluation quality). The award ceiling is listed at $200,000, and the CDC expected to make up to two awards, underscoring that this is a targeted, competitive initiative intended to produce a small number of strong evaluations rather than many small projects. The original and current closing date for applications was February 12, 2016, and the opportunity was posted on November 30, 2015.
Eligibility is broad and includes multiple categories of public and private entities: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; and nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education for those nonprofit categories). This wide eligibility reflects the reality that effective transgender-focused HIV programming is often implemented across diverse systems, including health departments, clinics, universities, and community-led organizations.
Overall, the opportunity is best understood as a push to move locally tailored, community-driven combination HIV prevention and care interventions for transgender persons who have sex with men from "promising practice" into "evidence-supported practice." By funding rigorous evaluations that meet CDC evidence expectations, the program aims to identify which homegrown models produce meaningful, measurable improvements in prevention uptake, care engagement, and broader health stability, and to position successful approaches for replication, scaling, or further investment.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Evaluating Locally-Developed or Adapted (Homegrown) Combination HIV Prevention Interventions for Transgender Persons who have Sex with Men."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA PS 16 003.
Which federal agency is offering this funding?
This is a discretionary funding opportunity administered by HHS/CDC (Agency: HHS-CDC-HHSCDCERA).
What type of award mechanism is used?
The funding is offered through a cooperative agreement.
What does it mean that this grant is a cooperative agreement?
Based on the opportunity description, a cooperative agreement indicates CDC expects an active partnership role with recipients, which may include technical guidance, reporting expectations, and collaboration to support evaluation quality.
What is the main purpose of this funding opportunity?
The central purpose is to strengthen the evidence base for HIV-related programs serving transgender people who have sex with men by funding rigorous evaluations of interventions already used in real communities but not yet evaluated strongly enough to meet CDC standards for evidence.
Who is the focus population for the interventions being evaluated?
The focus population is transgender persons who have sex with men.
What kinds of interventions does this grant focus on?
The program focuses on "combination" HIV prevention interventions, meaning interventions that integrate multiple components rather than relying on a single service or message.
What does "combination HIV prevention intervention" mean in this opportunity?
In this opportunity, "combination" refers to approaches that integrate multiple components such as HIV prevention strategies, HIV care and treatment services, and additional social or structural supports that address barriers to health.
What are examples of components that may be included in a combination intervention?
Examples described include linkages to testing and prevention tools (such as PrEP navigation where relevant), support for engagement in HIV medical care for people living with HIV, adherence support, and wraparound services addressing barriers like stigma, discrimination, unstable housing, limited access to affirming care, legal or documentation issues, and other social determinants.
What does "homegrown" mean for this grant?
"Homegrown" means the intervention was locally developed or locally adapted by the applicant organization itself or by a partnering organization such as a community-based organization (CBO), community health center (CHC), or community service organization (CSO).
Does this funding support creating a brand-new intervention from scratch?
No. The opportunity is designed to test and document the effectiveness of interventions that are already in place or have been adapted to local cultural and service contexts, rather than funding the invention of entirely new programs.
Can applicants evaluate an intervention aimed at people who are HIV-negative?
Yes. Applicants are allowed to evaluate a homegrown intervention focused on transgender persons who are HIV-negative but at risk for infection.
Can applicants evaluate an intervention aimed at people living with HIV?
Yes. Applicants are also allowed to evaluate a homegrown intervention focused on transgender persons living with HIV.
How does the grant describe evaluation outcomes for HIV-negative participants?
For HIV-uninfected participants, evaluations would typically examine outcomes tied to prevention uptake and sustained risk reduction.
How does the grant describe evaluation outcomes for participants living with HIV?
For participants living with HIV, the emphasis would generally be on outcomes such as linkage to care, retention in care, medication adherence support, and progress along the HIV care continuum.
What kind of evaluation plan is expected?
The application must present an evaluation plan that aligns with CDC-published criteria for evidence, indicating CDC expects methodologically sound designs, clear outcome measures, and credible analytic approaches capable of showing whether the intervention is effective.
Why does CDC emphasize evaluations that meet evidence criteria?
The opportunity aims to move community-driven interventions from "promising practice" to "evidence-supported practice" by producing credible, broadly persuasive evidence about effectiveness.
What is the maximum award amount?
The award ceiling is listed at $200,000.
How many awards does CDC expect to make?
CDC expected to make up to two awards.
When was the opportunity posted?
The opportunity was posted on November 30, 2015.
What was the application closing date?
The original and current closing date for applications was February 12, 2016.
Which types of organizations are eligible to apply?
Eligibility includes: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; and nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education for those nonprofit categories).
Are nonprofit organizations eligible even if they do not have 501(c)(3) status?
Yes. The eligibility list includes nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education within those nonprofit categories).
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments and other tribal organizations are included in the eligibility list.
Are universities and colleges eligible to apply?
Yes. The eligibility list includes public and state-controlled institutions of higher education as well as private institutions of higher education.
Are local health departments and other government entities eligible?
Yes. The eligibility list includes state, county, and local governments, as well as special district governments.
What kinds of partners are specifically mentioned as possible sources of a homegrown intervention?
The opportunity mentions interventions developed or adapted by the applicant or by a partnering community-based organization (CBO), community health center (CHC), or community service organization (CSO).
What is the overall goal of funding these evaluations?
The overall goal is to identify which locally tailored, community-rooted combination HIV prevention and care models produce measurable improvements in prevention uptake, care engagement, and broader health stability, and to position successful approaches for replication, scaling, or further investment.
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