Opportunity Information: Apply for RFA CK 16 005
Apply for RFA CK 16 005
- The HHS-CDC-HHSCDCERA in the health sector is offering a public funding opportunity titled "Evaluating the Impact of Non-pharmaceutical Measures on the Incidence of Influenza-like Illness (ILI) among K-12 Students in the United States" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Nov 13, 2015 and posted on Nov 13, 2015.
- Applicants must submit their applications by Jan 15, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
This funding opportunity, titled "Evaluating the Impact of Non-pharmaceutical Measures on the Incidence of Influenza-like Illness (ILI) among K-12 Students in the United States" (RFA CK 16 005), is a CDC cooperative agreement aimed at generating rigorous, real-world evidence on how specific non-pharmaceutical interventions can reduce influenza-like illness among school-aged children. The core purpose is to run multi-year, community randomized trials in U.S. K-12 school settings to measure whether practical, school-based prevention strategies meaningfully lower illness and related disruptions. Rather than focusing on vaccines or medications, the project is designed to test behavioral and environmental approaches that schools can implement during respiratory illness seasons.
The interventions of interest must include a combination of measures, not just a single tactic. Applicants are expected to implement at least one social distancing approach along with improvements in personal hygiene and environmental hygiene inside schools. The social distancing strategies described include options such as reducing class sizes so students can be spaced farther apart (with a target of at least 3 feet between students) and shortening the in-person school day by shifting a portion of instruction to remote learning systems. In addition to these, the program allows for the optional use of disposable medical face masks as a source control measure, specifically for students who develop respiratory symptoms (with or without fever) while they are at school. Overall, the emphasis is on interventions that can be operationalized in typical school environments and evaluated over multiple years to capture consistent patterns and seasonal variation.
The outcomes are clearly defined and oriented toward both practical school impacts and laboratory-confirmed public health measures. The first primary outcome is the incidence of ILI-associated student absenteeism, capturing how often students miss school due to influenza-like symptoms and providing a direct indicator of educational disruption. The second outcome is the incidence of laboratory-confirmed respiratory infections, assessed using multiplex PCR testing. This laboratory component is important because it moves beyond symptom-based reporting and helps determine whether changes in absenteeism and illness correspond to confirmed respiratory pathogens, strengthening the reliability of the findings and allowing comparisons across schools, years, and intervention combinations.
Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning the CDC is likely to have substantial programmatic involvement during the project period compared with a standard grant. The awarding agency is HHS/CDC (HHS-CDC-HHSCDCERA). The opportunity was posted and created on November 13, 2015, with an original and current closing date of January 15, 2016. The expected number of awards is two, with an award ceiling of $500,000, indicating that the program is structured to support a small number of relatively intensive, well-controlled trials rather than a large portfolio of smaller projects.
Eligibility is broad and spans many organization types that can credibly conduct or support school-based research and implementation. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding IHEs in those categories); for-profit organizations other than small businesses; small businesses; and additional applicants as clarified in the funding notice. This wide eligibility reflects the reality that large school-based trials often require partnerships among school districts, local or state agencies, universities, community organizations, and sometimes private-sector implementers or evaluators.
Taken together, the opportunity is focused on building actionable evidence for K-12 decision-makers and public health leaders about which school-based non-pharmaceutical measures, or combinations of measures, reduce influenza-like illness and confirmed respiratory infections, and to what extent those measures can curb absenteeism. The multi-year, randomized community trial approach signals an intent to produce results that are credible, generalizable, and useful for policy and operational planning in future respiratory illness seasons.
Frequently Asked Questions (FAQs)
What is the title and identifier of this funding opportunity?
The funding opportunity is titled "Evaluating the Impact of Non-pharmaceutical Measures on the Incidence of Influenza-like Illness (ILI) among K-12 Students in the United States" and is identified as RFA CK 16 005.
What is the main goal of this cooperative agreement?
The goal is to generate rigorous, real-world evidence on whether practical, school-based non-pharmaceutical interventions (NPIs) can reduce influenza-like illness (ILI) among K-12 students in the United States. The emphasis is on measuring meaningful reductions in illness and related disruptions such as absenteeism.
What type of projects is CDC trying to fund under this opportunity?
This opportunity is designed to support multi-year, community randomized trials conducted in U.S. K-12 school settings. The trials are meant to evaluate combinations of school-based prevention strategies across multiple respiratory illness seasons.
Is this opportunity focused on vaccines or medications?
No. The project explicitly focuses on non-pharmaceutical, behavioral, and environmental approaches that schools can implement during respiratory illness seasons, rather than vaccines or medications.
Do applicants need to test a single intervention or multiple interventions together?
Applicants are expected to implement a combination of measures, not just a single tactic. The interventions of interest must include at least one social distancing approach along with improvements in personal hygiene and environmental hygiene inside schools.
What kinds of social distancing strategies are described in the opportunity?
The notice describes social distancing options such as reducing class sizes to allow more spacing between students (with a target of at least 3 feet between students) and shortening the in-person school day by shifting a portion of instruction to remote learning systems.
Are face masks included in the allowable interventions?
Yes, disposable medical face masks are described as an optional source control measure. They are specifically intended for students who develop respiratory symptoms (with or without fever) while they are at school.
What does the opportunity mean by personal hygiene and environmental hygiene improvements?
The opportunity states that interventions must include improvements in personal hygiene and environmental hygiene inside schools, alongside at least one social distancing approach. The specific tactics are not further detailed in the provided summary, but the focus is on measures that can be operationalized in typical school environments.
What are the primary outcomes that funded projects must measure?
Two primary outcomes are specified: (1) the incidence of ILI-associated student absenteeism, and (2) the incidence of laboratory-confirmed respiratory infections.
How is ILI-associated student absenteeism defined as an outcome in this opportunity?
It is described as tracking how often students miss school due to influenza-like symptoms. This outcome is intended to capture a direct indicator of educational disruption related to illness.
How are laboratory-confirmed respiratory infections measured?
Laboratory-confirmed respiratory infections are assessed using multiplex PCR testing. This lab component is intended to go beyond symptom-based reporting and strengthen confidence in the findings by identifying confirmed respiratory pathogens.
Why does the opportunity include laboratory testing in addition to symptom-based measures?
The summary explains that lab testing strengthens reliability by determining whether changes in absenteeism and illness correspond to confirmed respiratory pathogens, which supports comparisons across schools, years, and intervention combinations.
What funding mechanism is being used?
This is a discretionary funding opportunity using a cooperative agreement mechanism.
What does it mean that this is a cooperative agreement?
In this opportunity, a cooperative agreement indicates the CDC is likely to have substantial programmatic involvement during the project period compared with a standard grant.
Which agency is offering the award?
The awarding agency is HHS/CDC (listed as HHS-CDC-HHSCDCERA).
When was the opportunity posted and when did it close?
The opportunity was posted and created on November 13, 2015. The original and current closing date is January 15, 2016.
How many awards does CDC expect to make?
The expected number of awards is two.
What is the maximum award amount (award ceiling)?
The award ceiling is $500,000.
What does the small number of awards suggest about the program design?
Because only two awards are expected and the work involves multi-year community randomized trials, the program appears designed to support a small number of intensive, well-controlled studies rather than many smaller projects.
Who is eligible to apply?
Eligibility is broad and includes: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding IHEs in those categories); for-profit organizations other than small businesses; small businesses; and additional applicants as clarified in the funding notice.
Are school districts eligible applicants?
Yes. Independent school districts are explicitly listed as eligible.
Are institutions of higher education eligible applicants?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other tribal organizations are included among eligible applicants.
Are nonprofit organizations eligible even if they do not have 501(c)(3) status?
Yes. Nonprofits with or without 501(c)(3) status are listed as eligible (excluding institutions of higher education in those nonprofit categories).
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Does the opportunity expect partnerships across multiple organizations?
The summary notes that broad eligibility reflects the reality that large school-based trials often require partnerships among school districts, local or state agencies, universities, community organizations, and sometimes private-sector implementers or evaluators.
What settings must the interventions be implemented in?
The interventions are intended to be implemented in U.S. K-12 school settings and be practical for typical school environments.
How long are projects expected to run?
The opportunity emphasizes multi-year trials designed to capture consistent patterns and seasonal variation across respiratory illness seasons.
What kinds of decisions are the results intended to support?
The opportunity is intended to build actionable evidence for K-12 decision-makers and public health leaders about which combinations of school-based non-pharmaceutical measures reduce ILI and confirmed respiratory infections, and the extent to which these measures curb absenteeism.
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