Opportunity Information: Apply for RFA RM 12 021
Apply for RFA RM 12 021
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Evaluation of Multi omic Data in Understanding the Human Microbiomes Role in Health and Disease (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Nov 30, 2012 and posted on Nov 30, 2012.
- Applicants must submit their applications by Feb 8, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: City or township governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts County governments Small businesses Public and State controlled institutions of higher education Private institutions of higher education State governments Public housing authorities/Indian housing authorities Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This funding opportunity, titled "Evaluation of Multi-omic Data in Understanding the Human Microbiome's Role in Health and Disease (U54)," is a National Institutes of Health (NIH) cooperative agreement solicitation under the NIH Common Fund Human Microbiome Project. Its central aim is to support large, team-based projects that generate and integrate multiple layers of microbiome and host data from well-characterized human cohorts in order to create a high-value resource for the broader research community. The focus is not simply on collecting samples, but on producing standardized, multi-omic datasets tied to carefully defined clinical phenotypes so that the resulting information can be reused to study how the microbiome relates to a specific disease or health state.
The FOA emphasizes two core project requirements. First, awardees are expected to generate microbiome taxonomic, metagenomic, and functional data from clinical biospecimens taken from one or more cohorts of carefully phenotyped participants. In practical terms, this means projects should start with subjects whose disease status or health condition has been rigorously assessed, and then produce comprehensive microbiome measurements, such as identification of which microbes are present (taxonomy), what genetic potential those microbial communities carry (metagenomics), and functional readouts that help indicate what the microbes may be doing biologically. Second, the program requires that investigators combine microbiome data with host data, integrating information about the human participants with the microbial measurements to produce a community resource. The expectation is that these integrated datasets will be broadly useful beyond the original study team, enabling future analyses, method development, and comparative studies across conditions.
Administratively, this announcement is issued as a cooperative agreement (U54), which typically means NIH will have substantial programmatic involvement compared with a standard research grant. The opportunity is categorized as discretionary funding within the health research area and is associated with CFDA number 93.310 (Trans-NIH Research Support). The estimated total funding amount listed for the opportunity is $5,000,000, and there is no cost sharing or matching requirement, which allows applicants to propose projects without needing to secure additional mandatory non-federal contributions.
The eligibility section indicates a wide range of domestic applicant organizations can apply. Eligible applicants include federal-recognized and other Native American tribal governments and organizations, state and local governments (including counties, cities or townships, special district governments, and public housing authorities), public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other than small businesses), independent school districts, and other organization types described in the full announcement. The opportunity also explicitly includes many institution types often referenced in federal eligibility language, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), and faith-based or community-based organizations, as well as U.S. territories or possessions. Foreign institutions are not eligible to apply as applicant organizations, although non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement, which provides a pathway for international collaboration without making a foreign institution the primary applicant.
Key dates show that the announcement was posted and created on November 30, 2012, with an original and current closing date of February 8, 2013, and an archive date of March 11, 2013. The funding opportunity number is RFA-RM-12-021, and the NIH is listed as the sponsoring agency. The full announcement was made available through the NIH grants website, and technical assistance for accessing or linking to the announcement is directed to the NIH Office of Extramural Research (OER) webmaster contacts provided in the notice.
Overall, the opportunity is designed for groups that can assemble clinically meaningful cohorts, generate high-quality multi-omic microbiome datasets from clinical biospecimens, and integrate those data with host information in a way that produces a durable, shareable research resource aligned with the Human Microbiome Project’s broader goals.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Evaluation of Multi-omic Data in Understanding the Human Microbiome's Role in Health and Disease (U54)."
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What program is this opportunity associated with?
It is a solicitation under the NIH Common Fund Human Microbiome Project.
What is the funding opportunity number (FOA number)?
The funding opportunity number is RFA-RM-12-021.
What type of award mechanism is being used?
This is a cooperative agreement under the U54 activity code.
What does it mean that this is a cooperative agreement (U54)?
As a cooperative agreement, the NIH is expected to have substantial programmatic involvement compared with a standard research grant. The solicitation frames this as a team-based effort aligned with broader program goals and community resource development.
What is the central aim of this opportunity?
The central aim is to support large, team-based projects that generate and integrate multiple layers of microbiome and host data from well-characterized human cohorts, creating a high-value resource for the broader research community.
Is the focus mainly on collecting samples?
No. The emphasis is on producing standardized, multi-omic datasets tied to carefully defined clinical phenotypes, so the resulting information can be reused to study how the microbiome relates to a specific disease or health state.
What are the two core project requirements described in the announcement?
First, awardees are expected to generate microbiome taxonomic, metagenomic, and functional data from clinical biospecimens taken from one or more carefully phenotyped cohorts. Second, investigators must combine microbiome data with host data and integrate them to produce a community resource.
What kinds of microbiome data are expected to be generated?
The announcement calls for microbiome taxonomic data (which microbes are present), metagenomic data (genetic potential of the microbial community), and functional data (readouts that help indicate what microbes may be doing biologically).
What is meant by "well-characterized" or "carefully phenotyped" human cohorts?
Projects are expected to start with participants whose disease status or health condition has been rigorously assessed and clearly defined, so that multi-omic datasets can be reliably linked to specific clinical phenotypes.
What does "host data" refer to in this context?
Host data refers to information about the human participants that can be integrated with the microbiome measurements to create a more broadly useful dataset for the community.
Why does the FOA emphasize integrating microbiome and host data?
The intent is to create integrated datasets that are broadly useful beyond the original study team, enabling future analyses, method development, and comparative studies across conditions.
What is the intended output for the broader research community?
The opportunity is intended to produce a durable, shareable community resource consisting of standardized, integrated multi-omic microbiome and host datasets tied to carefully defined clinical phenotypes.
What is the estimated total funding amount listed for this opportunity?
The estimated total funding amount is $5,000,000.
Is this considered discretionary funding, and what area does it fall under?
Yes. It is categorized as discretionary funding within the health research area.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.310 (Trans-NIH Research Support).
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Which types of U.S. organizations are eligible to apply?
Eligible domestic applicants include (as described in the notice) tribal governments and organizations, state and local governments (including counties, cities or townships, special district governments, and public housing authorities), public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other than small businesses), independent school districts, and other organization types described in the full announcement.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The eligibility language explicitly includes institution types commonly referenced in federal eligibility, including HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, and faith-based or community-based organizations.
Are U.S. territories or possessions included?
Yes. U.S. territories or possessions are explicitly included in the eligibility description provided.
Can foreign institutions apply as the applicant organization?
No. Foreign institutions are not eligible to apply as applicant organizations.
Are any international collaborations allowed?
Yes. Non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by the NIH Grants Policy Statement, which allows international collaboration without making a foreign institution the primary applicant.
When was the opportunity posted and created?
The notice states it was posted and created on November 30, 2012.
What is the closing date for applications?
The original and current closing date listed is February 8, 2013.
When was this opportunity archived?
The archive date listed is March 11, 2013.
Where was the full announcement made available?
The full announcement was made available through the NIH grants website.
Who is listed for technical assistance related to accessing or linking to the announcement?
Technical assistance for accessing or linking to the announcement is directed to the NIH Office of Extramural Research (OER) webmaster contacts provided in the notice.
What kinds of teams or projects is this opportunity designed for?
It is designed for groups that can assemble clinically meaningful cohorts, generate high-quality multi-omic microbiome datasets from clinical biospecimens, and integrate those data with host information to produce a shareable research resource aligned with Human Microbiome Project goals.
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