Opportunity Information: Apply for PA 07 130
Apply for PA 07 130
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Evolution of Infectious Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Dec 17, 2009 and posted on Dec 8, 2006.
- Applicants must submit their applications by Jan 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Special district governments City or township governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Independent school districts Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Evolution of Infectious Diseases (R01) opportunity (Funding Opportunity Number PA-07-130) is a National Institutes of Health (NIH) Funding Opportunity Announcement that supports research aimed at uncovering the evolutionary principles behind how infectious diseases emerge, spread, and can be contained. Rather than focusing on developing treatments for any single disease, the program is geared toward basic, discovery-driven work that clarifies fundamental biological rules and patterns that apply broadly across pathogens and host-pathogen systems. In practice, that means applications should be framed around generalizable evolutionary mechanisms and concepts, not as disease-specific product development or narrowly clinical efficacy studies.
A central theme of the announcement is interdisciplinary collaboration, specifically encouraging proposals that connect quantitative and computational approaches with experimental, clinical, or field-based research. The FOA explicitly calls for projects that bridge areas like mathematical modeling, statistics, computational biology, phylogenetics, and other quantitative methods with real-world biological data and observations collected in the lab, in clinical settings, or in natural populations. The intent is to fund work where theory and data inform each other, for example, where models generate testable predictions that are then evaluated through experiments or surveillance, or where empirical findings drive improved evolutionary models.
Within that broad scope, NIH highlights several topic areas as particularly relevant. One is the evolution of pathogens themselves, which can include questions about how viruses, bacteria, parasites, or fungi adapt over time, how genetic variation is generated and maintained, and how selective pressures shape traits like transmissibility, virulence, immune escape, host range, and drug resistance. Another emphasized area is the evolutionary dynamics of host-pathogen systems, which points to co-evolutionary processes and feedback loops between host immunity and pathogen adaptation, as well as population-level evolutionary dynamics influenced by ecology, demography, and contact networks. A third area of interest is the evolutionary consequences of intervention strategies, meaning research on how vaccines, antimicrobials, vector control, quarantine, or other public health measures can alter selection pressures and potentially lead to unintended evolutionary outcomes, such as resistance, strain replacement, or shifts in virulence.
The mechanism of support is the NIH Research Project Grant (R01), which is typically used for mature, hypothesis-driven projects with a defined scope and a multi-year research plan. The announcement notes that award size and project duration are expected to vary because the nature of proposed research can differ substantially across applicants. NIH does not specify a fixed total funding amount or a set number of awards in the summary provided; instead, the final number and size of awards depend on factors such as the volume of applications, scientific merit, program priorities, project length, and budget requests.
Eligibility for this FOA is broad. A wide range of U.S.-based organizations can apply, including public and private institutions of higher education, state and local governments (including counties, cities/townships, special district governments), independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. The announcement also indicates that foreign institutions are eligible to apply, that eligible federal government agencies can apply, and that faith-based and community-based organizations may apply as well, which opens participation to a wide spectrum of research-capable organizations both within and outside the United States. The opportunity does not require cost sharing or matching.
Key administrative details include that the opportunity is categorized as discretionary funding and uses the grant instrument type, with the funding activity category listed as health. The CFDA number associated with the program is 93.859 (Biomedical Research and Research Training). The FOA was posted on December 8, 2006, and it used multiple receipt dates (meaning applications could be accepted on several scheduled due dates rather than only once). The record indicates a current closing date of January 7, 2010, with an archive date of February 7, 2010, reflecting that this particular announcement cycle is historical. Applicants looking for specifics beyond the summary, such as submission dates, required components, review criteria, and any institute-specific considerations, would be directed to the full announcement link hosted by NIH at http://grants.nih.gov/grants/guide/pa-files/PA-07-130.html. For technical access issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: The Evolution of Infectious Diseases (R01) - NIH (PA-07-130)
What is the PA-07-130 funding opportunity?
PA-07-130 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "The Evolution of Infectious Diseases (R01)". It supports research aimed at uncovering evolutionary principles that explain how infectious diseases emerge, spread, and can be contained.
What is the main purpose of this FOA?
The main purpose is to fund basic, discovery-driven research that clarifies broad, generalizable evolutionary rules and patterns across pathogens and host-pathogen systems, rather than focusing on developing treatments or products for a single disease.
What type of research does this opportunity emphasize?
This FOA emphasizes research framed around generalizable evolutionary mechanisms and concepts. Applications are expected to focus on fundamental biological and evolutionary principles that apply broadly, not narrowly on disease-specific product development or purely clinical efficacy studies.
Is this grant intended for developing a treatment or product for one specific disease?
No. The FOA explicitly indicates the program is not centered on developing treatments for any single disease. Instead, it prioritizes research that advances understanding of evolutionary processes that broadly shape infectious disease dynamics.
What is meant by “interdisciplinary collaboration” in this FOA?
The FOA centrally encourages projects that connect quantitative and computational approaches with experimental, clinical, or field-based research. The intent is to support work where theory and data directly inform each other.
What kinds of quantitative or computational approaches are encouraged?
The FOA explicitly calls out bridging areas such as mathematical modeling, statistics, computational biology, phylogenetics, and related quantitative methods with real biological data and observations.
What kinds of empirical data sources does NIH expect these quantitative methods to connect with?
The FOA describes integration with data and observations collected in laboratory studies, clinical settings, or field/natural population contexts (for example, surveillance or observational datasets).
What does “models generate testable predictions” mean in the context of this FOA?
The FOA describes a desired approach where quantitative models produce predictions that can be tested through experiments, surveillance, or other empirical work, and where empirical findings can also drive refinement of evolutionary models.
What topic areas are specifically highlighted as relevant?
NIH highlights several areas, including: (1) evolution of pathogens, (2) evolutionary dynamics of host-pathogen systems, and (3) evolutionary consequences of intervention strategies.
What does “evolution of pathogens” include under this FOA?
This area can include research on how viruses, bacteria, parasites, or fungi adapt over time; how genetic variation is generated and maintained; and how selective pressures shape traits such as transmissibility, virulence, immune escape, host range, and drug resistance.
What does “evolutionary dynamics of host-pathogen systems” mean here?
In this FOA, it refers to co-evolutionary processes and feedback loops between host immunity and pathogen adaptation, along with population-level evolutionary dynamics influenced by factors like ecology, demography, and contact networks.
What are “evolutionary consequences of intervention strategies”?
This topic area involves studying how interventions such as vaccines, antimicrobials, vector control, quarantine, or other public health measures change selection pressures and may lead to unintended outcomes like resistance, strain replacement, or shifts in virulence.
What funding mechanism is used for this opportunity?
The FOA uses the NIH Research Project Grant (R01) mechanism, which is typically used for mature, hypothesis-driven projects with defined scope and multi-year research plans.
How much funding is available per award?
The summary provided does not specify a fixed award size. It notes that award size is expected to vary because project needs differ across applicants.
How long can a project last under this FOA?
The summary indicates that project duration is expected to vary depending on the nature of the proposed research. A specific maximum duration is not provided in the summary.
Does NIH state how many awards it plans to make?
No. The summary does not list a specific total funding amount or number of awards. It states that the number and size of awards depend on factors such as application volume, scientific merit, program priorities, project length, and budget requests.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations such as public and private institutions of higher education, state and local governments (including counties, cities/townships, and special district governments), independent school districts, public housing authorities/Indian housing authorities, Native American tribal governments and tribal organizations, and other eligible entities described in the FOA summary.
Are foreign institutions eligible to apply?
Yes. The summary states that foreign institutions are eligible to apply.
Can federal government agencies apply?
Yes. The summary indicates that eligible federal government agencies can apply.
Are faith-based and community-based organizations eligible?
Yes. The summary states that faith-based and community-based organizations may apply, indicating broad organizational eligibility as long as the organization is research-capable and fits the FOA requirements.
Is cost sharing or matching required?
No. The summary specifies that the opportunity does not require cost sharing or matching.
What type of funding is this classified as?
The opportunity is categorized as discretionary funding, uses a grant instrument type, and the funding activity category is listed as health.
What is the CFDA number for this program?
The CFDA number associated with this program is 93.859 (Biomedical Research and Research Training).
When was this FOA posted?
The FOA record indicates it was posted on December 8, 2006.
What does it mean that the FOA used “multiple receipt dates”?
It means applications could be accepted on several scheduled due dates rather than only a single, one-time deadline.
Is this FOA still open?
The record indicates a current closing date of January 7, 2010 and an archive date of February 7, 2010, meaning this particular FOA cycle is historical based on the information provided.
Where can applicants find the full announcement and official requirements?
The full FOA is hosted by NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-07-130.html. The summary notes that details such as submission dates, required components, review criteria, and institute-specific considerations are found in the full announcement.
Who should be contacted for technical access issues?
The contact listed for technical access issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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