Opportunity Information: Apply for RFA HL 13 005
Apply for RFA HL 13 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Excellence in Hemoglobinopathies Research Award (EHRA) (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jan 18, 2012 and posted on Jan 18, 2012.
- Applicants must submit their applications by May 8, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $14,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: Independent school districts For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Private institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Public and State controlled institutions of higher education State governments Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Excellence in Hemoglobinopathies Research Award (EHRA) (U54) is a National Institutes of Health (NIH) cooperative agreement funding opportunity designed to push forward high impact research on hemoglobin disorders such as sickle cell disease and thalassemias. The program is built around the idea that major advances in these diseases are most likely when basic scientists, translational researchers, and clinical hematologists work in tightly coordinated teams. To make that happen, the FOA supports projects that deliberately cross disciplinary boundaries and are structured to move discoveries from fundamental biology toward practical clinical application. The award mechanism is a U54 cooperative agreement, which typically means substantial NIH involvement and partnership during the life of the project, rather than a purely investigator-directed grant.
The core expectation is that an applicant proposes a single, integrated project organized around one unifying scientific theme. Instead of funding a set of unrelated studies, the EHRA model emphasizes cohesion: multiple investigators contribute distinct expertise toward a shared goal, and the collaboration itself is part of the innovation. The FOA specifically calls for involvement from two or more relevant disciplines, with the intent that the work meaningfully links basic observations to applied clinical research. In practical terms, competitive applications would be expected to show how the team will translate mechanistic insights, new technologies, or novel experimental findings into approaches that can inform diagnosis, prevention, or treatment strategies in real patient settings.
The project period is five years. The opportunity (Funding Opportunity Number RFA-HL-13-005) was posted January 18, 2012, with an application due date of May 8, 2012, and an archive date of June 8, 2012. The FOA falls under the health category, with CFDA number 93.839 (Blood Diseases and Resources Research). NIH indicated an estimated total funding amount of $14,000,000 for the overall program, and an award ceiling listed at $150,000. Cost sharing or matching is not required, which reduces barriers for applicants who may not have non-federal resources to contribute.
Eligibility is broad across the U.S. research and public service landscape. Eligible applicant types include public and private institutions of higher education, nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), state, county, and city or township governments, special district governments, public housing authorities/Indian housing authorities, independent school districts, small businesses, and for-profit organizations other than small businesses. The FOA also explicitly includes a range of mission-driven and community-relevant institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, tribally controlled colleges and universities (TCCUs), certain tribal organizations and governments, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
At the same time, the FOA draws clear lines around foreign participation. Non-U.S. (foreign) institutions are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components as defined by the NIH Grants Policy Statement are allowed, meaning a U.S.-based applicant can include certain well-justified international elements of the work when they meet NIH policy requirements. This structure supports collaboration with international sites when scientifically or clinically important, while keeping the primary applicant organization based in the United States.
Overall, the EHRA (U54) is aimed at accelerating progress in hemoglobinopathies by funding a single, theme-driven, multidisciplinary research effort that is intentionally built for translation. It prioritizes strong collaboration across scientific and clinical domains, encourages broad participation across many types of U.S. institutions, and uses the cooperative agreement format to enable active NIH engagement as the project advances from discovery-oriented science toward outcomes with clinical relevance. For the full announcement and detailed requirements, the FOA points applicants to the NIH guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-13-005.html, and provides NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
Excellence in Hemoglobinopathies Research Award (EHRA) (U54) - FAQs
What is the Excellence in Hemoglobinopathies Research Award (EHRA) (U54)?
The Excellence in Hemoglobinopathies Research Award (EHRA) is an NIH cooperative agreement funding opportunity meant to advance high-impact research on hemoglobin disorders, including sickle cell disease and the thalassemias. It is designed to support an integrated, team-based project that connects basic science to translational and clinically relevant research.
What funding mechanism is used for this opportunity?
This opportunity uses the U54 cooperative agreement mechanism. A cooperative agreement generally involves substantial NIH involvement and partnership during the project period, rather than being entirely investigator-directed.
What is the main scientific focus of the program?
The program focuses on hemoglobinopathies (hemoglobin disorders), specifically highlighting sickle cell disease and thalassemias as examples of the conditions of interest.
What kind of project structure does the EHRA expect?
The core expectation is a single, integrated project organized around one unifying scientific theme. The EHRA model is not intended to fund a collection of unrelated studies; instead, it emphasizes cohesion, coordination, and collaboration across a shared scientific goal.
Does the FOA require a multidisciplinary team?
Yes. The FOA specifically calls for involvement from two or more relevant disciplines. The intent is that the project meaningfully crosses disciplinary boundaries and links basic observations to applied clinical research.
What kinds of researchers are expected to be involved?
The opportunity is built around the idea that major advances are most likely when basic scientists, translational researchers, and clinical hematologists work in tightly coordinated teams.
What does "translation" mean in the context of this FOA?
Based on the description provided, translation refers to intentionally moving discoveries from fundamental biology toward practical clinical application. Competitive projects would be expected to show how mechanistic insights, new technologies, or novel experimental findings can inform real-world approaches relevant to diagnosis, prevention, or treatment strategies in patient settings.
What is the project period (duration) for the award?
The project period is five years.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HL-13-005.
When was this FOA posted, and what were the key dates?
The FOA was posted on January 18, 2012. The application due date was May 8, 2012, and the archive date was June 8, 2012.
What is the CFDA number for this opportunity?
The CFDA number is 93.839, listed as Blood Diseases and Resources Research.
What is the estimated total funding amount for the overall program?
NIH indicated an estimated total funding amount of $14,000,000 for the overall program.
Is there an award ceiling listed?
Yes. The opportunity lists an award ceiling of $150,000.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad across the U.S. research and public service landscape. Eligible applicant types include public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), and multiple levels of government (state, county, city, township), among others.
Are small businesses eligible to apply?
Yes. Small businesses are included in the list of eligible applicant types.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are listed as eligible applicant types.
Are K-12 education entities eligible?
Independent school districts are explicitly listed among eligible applicants.
Are special district governments eligible?
Yes. Special district governments are included in the eligibility list.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included in the eligibility list.
Does the FOA encourage participation by specific institution types (like HBCUs and Hispanic-serving institutions)?
Yes. The FOA explicitly includes a range of mission-driven and community-relevant institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities (TCCUs), among others.
Are tribal governments and tribal organizations included in eligibility?
Yes. The FOA includes certain tribal organizations and governments, as well as tribally controlled colleges and universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included among the eligible entities.
Are U.S. territories or possessions included?
Yes. The FOA explicitly includes U.S. territories or possessions as eligible.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are listed as eligible applicants.
Can foreign (non-U.S.) institutions apply as the applicant organization?
No. Non-U.S. (foreign) institutions are not eligible to apply as applicant organizations.
Can a non-domestic component of a U.S. organization apply as the applicant?
No. Non-domestic components of U.S. organizations are also not eligible to apply as applicant organizations.
Are any international elements allowed in the project?
Yes. The FOA states that foreign components (as defined by the NIH Grants Policy Statement) are allowed. This means a U.S.-based applicant can include certain well-justified international elements when they meet NIH policy requirements.
Where can applicants find the full announcement?
The FOA points applicants to the NIH guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-13-005.html for the full announcement and detailed requirements.
Who is listed for help with access or linking issues?
The FOA mentions NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
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