Opportunity Information: Apply for RFA MH 14 214
Apply for RFA MH 14 214
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) for Neuroscience and Disorders of the Nervous System (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.866 Aging Research.
- This funding opportunity was created on Nov 8, 2013 and posted on Nov 8, 2013.
- Applicants must submit their applications by Feb 3, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Special district governments Independent school districts Private institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) for Neuroscience and Disorders of the Nervous System (R01) is a National Institutes of Health (NIH) funding opportunity designed to back unusually bold, original, and potentially transformative research projects in neuroscience and nervous system disorders. It specifically targets applications that pursue exceptionally novel hypotheses or attempt to crack remarkably difficult problems that have been resistant to standard approaches. The central idea is to encourage research that may be considered unconventional or high-risk, as long as there is a clear rationale that success would produce an especially high-impact payoff for the field, such as resolving a major scientific bottleneck, reframing an established problem, or opening an entirely new area of investigation.
This program uses the NIH Research Project Grant (R01) mechanism, which is intended for full-scale research projects rather than small feasibility studies. A key feature of the announcement is that it emphasizes support for new projects, not continuations of ongoing work, and it explicitly states that it is not intended for pilot research. In practice, that means proposals should be mature enough to justify an R01-level scope and should present a coherent plan to pursue a daring idea, even if the outcome is uncertain. The FOA acknowledges that the proposed work may have a high chance of failure, but it expects applicants to articulate why the risk is worth taking and what the scientific or clinical impact would be if the project succeeds.
The opportunity falls under NIH and is listed as a discretionary grant program with activity areas tied to education and health. It is associated with multiple CFDA numbers reflecting NIH portfolios that intersect with neuroscience and brain-related disorders, including Mental Health Research Grants (93.242), Drug Abuse and Addiction Research Programs (93.279), Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853), and Aging Research (93.866). There is no cost-sharing or matching requirement, which means applicants are not required to provide non-federal matching funds as a condition of receiving an award.
Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), and various levels of government such as state, county, city/township, and special district governments. The eligibility list also extends to tribal entities and tribal-serving organizations, independent school districts, and public housing authorities/Indian housing authorities. The FOA further clarifies that many mission-focused institution types are eligible, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, non-U.S. entities are eligible to apply, and foreign components of U.S. organizations are allowed consistent with NIH policy language referenced in the announcement.
Administratively, the opportunity is identified by Funding Opportunity Number RFA-MH-14-214 and was posted on November 8, 2013. The original and current closing date listed is February 3, 2014, and the archive date is March 6, 2014, indicating it was a time-limited solicitation that is no longer open under that specific posting. The full announcement and official instructions were provided through the NIH grants guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-14-214.html). For technical problems accessing the announcement, NIH directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
In short, EUREKA (R01) was structured to fund ambitious neuroscience research that conventional review or incremental funding routes might overlook, prioritizing projects that are truly groundbreaking and that could meaningfully accelerate knowledge or reshape understanding of nervous system function and disease if they work. The program signals a willingness to tolerate substantial uncertainty in exchange for the possibility of outsized scientific returns, while still expecting an R01-caliber research plan that goes beyond preliminary or exploratory pilot aims.
FAQs: EUREKA for Neuroscience and Disorders of the Nervous System (R01)
What is the EUREKA for Neuroscience and Disorders of the Nervous System (R01) opportunity?
EUREKA (R01) is a National Institutes of Health (NIH) funding opportunity intended to support unusually bold, original, and potentially transformative research projects focused on neuroscience and disorders of the nervous system.
What kinds of projects is this program trying to fund?
This program is designed for applications that pursue exceptionally novel hypotheses or attempt to solve remarkably difficult problems that have resisted standard approaches. The emphasis is on unconventional, high-risk ideas where success would create an especially high-impact payoff for the field (for example, breaking a major scientific bottleneck, reframing an established problem, or opening a new area of investigation).
Is this program open to high-risk research?
Yes. The opportunity explicitly acknowledges that proposed work may have a high chance of failure, but expects applicants to explain why the risk is worth taking and what the scientific or clinical impact would be if the project succeeds.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is intended for full-scale research projects.
Is this meant for pilot studies or feasibility projects?
No. The announcement states it is not intended for pilot research. Proposals should be mature enough to justify an R01-level scope and should present a coherent plan to pursue a daring idea, even if the outcome is uncertain.
Does the program prioritize new projects or continuations of ongoing work?
It emphasizes support for new projects and is not positioned as a way to continue ongoing work.
What research areas does this opportunity relate to?
It focuses on neuroscience and disorders of the nervous system. The program is tied to education and health activity areas and aligns with NIH portfolios intersecting with brain-related research and disorders.
Which NIH/CFDA program areas are associated with this funding opportunity?
The opportunity references multiple CFDA areas reflecting relevant NIH portfolios, including Mental Health Research Grants (93.242), Drug Abuse and Addiction Research Programs (93.279), Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853), and Aging Research (93.866).
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of receiving an award.
Who is eligible to apply?
Eligibility is broad and includes domestic and international organizations. Eligible applicants include public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); and government entities such as state, county, city/township, and special district governments.
Are tribal entities and tribal-serving organizations eligible?
Yes. The eligibility list includes tribal entities and tribal-serving organizations.
Are independent school districts eligible to apply?
Yes. Independent school districts are listed among eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included in the eligibility list.
Are minority-serving institutions specifically named as eligible?
Yes. The opportunity notes that many mission-focused institution types are eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Can non-U.S. (foreign) organizations apply?
Yes. The announcement indicates that non-U.S. entities are eligible to apply.
Are foreign components of U.S. organizations allowed?
Yes. Foreign components of U.S. organizations are allowed, consistent with NIH policy language referenced in the announcement.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is RFA-MH-14-214.
When was this funding opportunity posted?
It was posted on November 8, 2013.
What was the application due date for this opportunity?
The original and current closing date listed is February 3, 2014.
Is this funding opportunity still open?
No. The archive date is March 6, 2014, and the listed closing date is in 2014, indicating this was a time-limited solicitation that is no longer open under that specific posting.
Where can applicants find the official announcement and instructions?
The announcement and official instructions were provided through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-14-214.html.
Who should be contacted for technical problems accessing the announcement?
For technical problems, NIH directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the main goal of the EUREKA (R01) program in plain terms?
The goal is to accelerate knowledge by funding ambitious neuroscience research that conventional review or incremental funding routes might overlook, while still requiring an R01-caliber, coherent research plan that goes beyond preliminary or exploratory pilot aims.
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