Opportunity Information: Apply for RFA GM 11 003
Apply for RFA GM 11 003
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 17, 2010 and posted on Aug 17, 2010.
- Applicants must submit their applications by Oct 21, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) funding opportunity (Funding Opportunity Number: RFA-GM-11-003) is an NIH discretionary grant program designed to back unusually bold, high-impact biomedical or biobehavioral research. The core aim is to support projects that tackle novel hypotheses or especially difficult scientific problems where a successful outcome would meaningfully accelerate knowledge or open up major new directions in areas aligned with the missions of one or more participating NIH Institutes. In practical terms, the program is looking for ideas that feel genuinely unconventional or transformative, not incremental extensions of well-trodden research paths.
A key feature of this FOA is its emphasis on new, stand-alone projects. It is explicitly not meant to fund continuation work on projects that are already underway. It also does not support pilot-style efforts that are limited in scope and primarily intended to generate preliminary data for a later, larger funding request. The expectation is that applicants propose a clear, innovative research plan that can be evaluated on its potential for exceptional impact rather than serving as a stepping-stone to another application.
The mechanism used is the standard NIH Research Project Grant (R01), which generally supports investigator-initiated research with defined aims and a multi-year plan. Under this FOA, the budget structure is capped to keep projects substantial but controlled. Applicants may request up to $800,000 in direct costs total over a maximum of four years, excluding consortium facilities and administrative (F and A) costs. Shorter project periods are allowed, with proportional totals noted in the announcement (up to $600,000 total for three years or $400,000 total for two years). Regardless of the overall duration, direct costs (again excluding consortium F and A) cannot exceed $250,000 in any single year.
NIH participation spans multiple Institutes and Centers, with funds and expected award counts allocated across them. The participating components and approximate commitments listed are: NIGMS at about $6 million for an anticipated 18 to 22 awards; NCI at about $3 million for 10 to 12 awards; NCCAM (now known as NCCIH) at about $400,000 for 1 award; NIAAA at about $600,000 for 2 awards; NIDCR at about $800,000 for 1 to 2 awards; NIDA at about $1 million for 3 to 4 awards; NIMH at about $2 million for 6 to 9 awards; and NINDS at about $2 million for 6 awards. As with most NIH opportunities, actual awards depend on the availability of funds and whether enough highly rated, meritorious applications are received.
Eligibility is broad and includes a range of organization types. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and additional institution types highlighted in the eligibility notes. Those specifically mentioned include Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and non-U.S. entities (foreign organizations). The FOA does not require cost sharing or matching.
Administratively, the opportunity was posted and created on August 17, 2010, with an original and current closing date of October 21, 2010, and an archive date of November 21, 2010. It is cataloged under multiple CFDA program areas that reflect the breadth of NIH missions involved, including oral health, complementary and integrative health, mental health, alcohol research, drug abuse and addiction, multiple cancer research categories, neuroscience and neurological disorders, and broader biomedical research and research training programs.
Overall, EUREKA (R01) is best understood as an NIH initiative meant to identify and fund research that is unusually creative and potentially game-changing, with clear boundaries that discourage incremental continuations or preliminary pilots. It provides a defined, capped R01 budget over up to four years, draws support from several major NIH Institutes, and is open to a wide range of domestic and international research organizations capable of executing ambitious, high-impact science.
Frequently Asked Questions (FAQs)
What is the EUREKA (R01) funding opportunity?
The Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) program is an NIH discretionary grant opportunity (Funding Opportunity Number: RFA-GM-11-003) intended to support unusually bold, high-impact biomedical or biobehavioral research. It focuses on projects that are genuinely unconventional or transformative rather than incremental extensions of established research paths.
What kinds of projects is EUREKA designed to support?
EUREKA is designed to support stand-alone research projects that tackle novel hypotheses or especially difficult scientific problems. The emphasis is on proposals where success would meaningfully accelerate knowledge or open major new directions in scientific areas aligned with the missions of one or more participating NIH Institutes or Centers.
What kinds of projects are not a fit for this FOA?
This FOA is explicitly not intended to fund continuation work on projects that are already underway. It also does not support pilot-style efforts that are limited in scope and primarily aimed at generating preliminary data for a later, larger funding request. The expectation is a complete, evaluable research plan with exceptional potential impact.
What grant mechanism is used for this opportunity?
The opportunity uses the NIH Research Project Grant (R01) mechanism, which generally supports investigator-initiated research with defined aims and a multi-year plan.
How much funding can an applicant request under EUREKA (R01)?
Applicants may request up to $800,000 in total direct costs over a maximum project period of four years, excluding consortium facilities and administrative (F and A) costs.
Are shorter project periods allowed, and how do the budget caps change?
Yes. Shorter project periods are allowed with proportional total direct cost caps noted in the announcement: up to $600,000 total for three years, or up to $400,000 total for two years (excluding consortium F and A costs).
Is there a per-year direct cost limit?
Yes. Direct costs (excluding consortium F and A) cannot exceed $250,000 in any single year, regardless of the total project duration.
Do the direct cost caps include consortium F and A costs?
No. The stated direct cost limits are described as excluding consortium facilities and administrative (F and A) costs.
Which NIH Institutes and Centers are participating in this FOA?
NIH participation spans multiple Institutes and Centers. The participating components listed are NIGMS, NCI, NCCAM (now NCCIH), NIAAA, NIDCR, NIDA, NIMH, and NINDS.
How much funding is each participating NIH component committing, and how many awards are anticipated?
The FOA lists approximate commitments and expected award counts by component, subject to availability of funds and application quality:
- NIGMS: about $6 million for an anticipated 18 to 22 awards
- NCI: about $3 million for 10 to 12 awards
- NCCAM (now NCCIH): about $400,000 for 1 award
- NIAAA: about $600,000 for 2 awards
- NIDCR: about $800,000 for 1 to 2 awards
- NIDA: about $1 million for 3 to 4 awards
- NIMH: about $2 million for 6 to 9 awards
- NINDS: about $2 million for 6 awards
Are the listed award numbers guaranteed?
No. As with most NIH opportunities, actual awards depend on the availability of funds and whether a sufficient number of highly rated, meritorious applications are received.
Who is eligible to apply?
Eligibility is broad and includes many organization types, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), and for-profit organizations (including small businesses and other for-profits). The eligibility notes also highlight additional institution types and non-U.S. entities (foreign organizations).
Does the FOA specifically mention minority-serving or special designation institutions?
Yes. The opportunity specifically mentions eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and foreign organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. Non-U.S. entities (foreign organizations) are specifically mentioned as eligible applicants.
Is cost sharing or matching required?
No. The FOA states that it does not require cost sharing or matching.
When was this funding opportunity posted, and what were the key dates?
The opportunity was posted and created on August 17, 2010. The original and current closing date listed is October 21, 2010. The archive date is November 21, 2010.
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number is RFA-GM-11-003.
What research areas does this FOA relate to?
The FOA is cataloged under multiple CFDA program areas reflecting the breadth of NIH missions involved. These include oral health, complementary and integrative health, mental health, alcohol research, drug abuse and addiction, multiple cancer research categories, neuroscience and neurological disorders, and broader biomedical research and research training programs.
What is the core goal of EUREKA (R01) in practical terms?
In practical terms, the program is looking for research ideas that feel truly unconventional or transformative and that, if successful, would significantly accelerate knowledge or create major new directions in fields aligned with participating NIH Institute missions.
Does EUREKA allow incremental extensions of existing research paths?
The FOA discourages incremental work. It is positioned to back unusually bold and high-impact projects, rather than incremental extensions of well-trodden research paths.
Is EUREKA intended to function as a stepping-stone to a later, larger NIH application?
No. The FOA states it does not support pilot-style efforts primarily intended to generate preliminary data for a later, larger funding request. Applications are expected to present a clear, innovative plan that can be evaluated on exceptional impact.
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