Exploratory Centers for Translational Research on the Clinical Neurobiology of Drug Addiction (P20) | Apply Online

Opportunity Summary:

The Exploratory Centers for Translational Research on the Clinical Neurobiology of Drug Addiction (P20) opportunity (Funding Opportunity Number RFA-DA-09-012) is a National Institutes of Health initiative, led through the National Institute on Drug Abuse (NIDA), aimed at jump-starting translational research centers focused on the clinical neurobiology of drug abuse and addiction. The central idea is to build organized, collaborative research teams that primarily study human neurobiology related to addiction, while also incorporating targeted preclinical work that directly supports, explains, or provides a mechanistic foundation for the human findings. In other words, the program is designed for groups that want to connect human neuroscience observations to underlying biological mechanisms using non-human models or other preclinical approaches, but with the human work clearly at the center of the effort.

This solicitation uses the NIH P20 mechanism, which is best understood as a planning and development grant for an emerging center rather than a fully mature, large-scale center award. The expectation is that, over the P20 funding period, applicants will build the infrastructure and organizational capacity needed for a sustainable translational research center. That includes assembling key personnel, creating or strengthening shared resources, and developing the operational pieces that make multi-project center science work (for example, coordinated recruitment or assessment pipelines, data management processes, access to specialized neurobiological methods, and cross-project governance). A major goal is to produce enough strong, high-quality data and demonstrate enough coherence and feasibility that the team is well-positioned to submit a competitive P50 translational research center application by the end of the P20 period.

A defining feature of this P20 is the required structure of the proposed center. Applicants must propose a set of scientific projects totaling at least three and no more than five. The projects should look and feel like scaled-down versions of traditional NIH research projects, meaning they are hypothesis-driven and scientifically substantive, but smaller in scope than what might be expected if each were submitted as a standalone R01-type application. Within this set of projects, the center must maintain a clear emphasis on human neurobiological research: the primary specific aim is expected to involve human neuroscience or human neurobiology. At the same time, at least one aim must include preclinical (non-human) research. The preclinical component is not meant to be a separate, disconnected track; it is supposed to directly inform the human work or help explain it mechanistically, reinforcing the translational nature of the center.

Another core theme is that this program is intentionally designed to encourage new collaborations and team formation. Because NIDA is trying to foster new research partnerships and interdisciplinary translational teams, the program explicitly welcomes high-risk and exploratory projects. Importantly, the FOA notes that preliminary data from newly formed or still-forming collaborations are not required, which lowers a common barrier for teams that have strong expertise but have not yet generated joint pilot data. However, the application still needs to demonstrate credible capacity to carry out the proposed collaborative work, meaning reviewers will look for evidence that the investigators, institutional environment, and available resources are sufficient to support the planned projects and the center-building goals.

In terms of funding, NIDA anticipated committing a total of 3.0 million dollars in fiscal year 2009 for this initiative, with the expectation of making roughly two to three awards. The opportunity is categorized as a discretionary grant program within the education and health activity area, and it is associated with CFDA number 93.279 (Drug Abuse and Addiction Research Programs). There is no cost-sharing or matching requirement listed, which means applicants are not expected to provide a formal match as a condition of award.

Eligibility is broad and includes a wide range of public and private entities. Eligible applicants include state, county, city/township, special district governments, independent school districts, and public housing authorities. It also includes public and state-controlled institutions of higher education and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and tribal organizations, including federally recognized tribal governments as well as other tribal entities. The FOA also indicates eligibility for various institution types and communities that NIH often highlights, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. It further lists U.S. territories or possessions and non-U.S. (foreign) organizations and regional organizations as eligible, reflecting NIH’s generally expansive eligibility framework for many research programs.

Key administrative details in the source information include a posted and creation date of December 3, 2008, with an original and current closing date of February 27, 2009, and an archive date of March 30, 2009. The full announcement was made available through the NIH Grants Guide (via the link provided in the notice). For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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