Opportunity Information: Apply for PAR 08 228
Apply for PAR 08 228
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Exploratory/Developmental Projects in Translational Research for Neuromuscular Disease (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Dec 5, 2008 and posted on Aug 5, 2008.
- Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Private institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education County governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Small businesses City or township governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Exploratory/Developmental Projects in Translational Research for Neuromuscular Disease (R21) (Funding Opportunity Number PAR 08-228) is an NIH grant opportunity designed specifically to move potential treatments for neuromuscular diseases through early, practical preclinical development steps. It is sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The central idea is to fund projects that tackle targeted, therapy-development tasks that sit upstream of an FDA submission, with the expectation that a successful R21 project will position the therapeutic program to proceed directly into a subsequent effort that completes the remaining work needed to support an Investigational New Drug (IND) application (for drugs/biologics) or an Investigational Device Exemption (IDE) application (for devices). In other words, the grant is meant to help teams clear key early hurdles in a translational pipeline so that the next stage can focus on finishing IND/IDE-enabling requirements.
The FOA is tightly focused on translational, preclinical development activities rather than discovery science. Only research aims that are required for therapy development are considered appropriate for support under this program. The announcement explicitly excludes clinical research, basic research, and studies centered on disease mechanisms. This makes it a poor fit for proposals that primarily seek to understand underlying biology, identify new pathways, or run trials in humans, and a better fit for proposals that are already oriented toward a defined therapeutic candidate, device concept, or development plan and need specific preclinical steps completed to de-risk and advance the program.
Funding is provided through the NIH Exploratory/Developmental R21 mechanism, which is commonly used for early-stage, milestone-oriented projects that generate critical feasibility or development-enabling data. The award ceiling listed is $200,000. The agencies anticipated committing about $1,000,000 per year total to support meritorious applications, with the exact number and size of awards depending on the quality of submissions, the proposed duration, and the budgets requested. No cost sharing or matching is required.
Eligibility is broad and includes many types of organizations. Eligible applicants include nonprofit organizations (including those with and without 501(c)(3) status), public and private institutions of higher education, for-profit organizations (including small businesses and other than small businesses), and a wide range of government entities (state, county, city/township, special district governments, and independent school districts), as well as public housing authorities/Indian housing authorities. The FOA also notes additional eligible applicants such as federally recognized and other tribal entities, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and non-U.S. (foreign) entities, as well as U.S. territories or possessions.
Key administrative details from the source listing include: the opportunity is categorized as discretionary funding and uses the grant funding instrument; the activity category is health; and the CFDA numbers associated with the participating NIH programs are 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The FOA was posted on August 5, 2008, with an original and current closing date of September 7, 2011, and an archive date of October 8, 2011, indicating it is no longer an active solicitation. The full announcement was hosted through the NIH grants website at the link provided in the record. For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: Exploratory/Developmental Projects in Translational Research for Neuromuscular Disease (R21) - PAR 08-228
What is the PAR 08-228 funding opportunity?
PAR 08-228 is an NIH Funding Opportunity Announcement (FOA) for Exploratory/Developmental Projects in Translational Research for Neuromuscular Disease using the R21 mechanism. It is designed to help advance potential therapies for neuromuscular diseases through practical early preclinical development steps.
Which NIH institutes sponsor this FOA?
The FOA is sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
What is the main goal of this program?
The main goal is to fund targeted, therapy-development tasks that occur upstream of an FDA submission. Successful projects are expected to position a therapeutic program so that a subsequent effort can focus on completing the remaining work needed to support an IND (for drugs/biologics) or an IDE (for devices).
How does this FOA fit into the translational pipeline?
This FOA is intended to help teams clear key early hurdles in a translational, preclinical pipeline. It supports development-oriented steps that de-risk and advance a program toward the point where the next stage can concentrate on IND/IDE-enabling requirements.
What kinds of research aims are considered appropriate for this FOA?
Only research aims that are required for therapy development are considered appropriate. The FOA is tightly focused on translational, preclinical development activities rather than discovery or mechanism-focused science.
What types of projects are explicitly excluded?
The announcement explicitly excludes clinical research, basic research, and studies centered on disease mechanisms. Projects that primarily aim to understand underlying biology, identify new pathways, or conduct trials in humans are not a good fit under this program as described.
Is this FOA a good fit for discovery science or disease mechanism studies?
No. Based on the description provided, it is a poor fit for proposals focused mainly on discovery science (for example, identifying new pathways) or studying disease mechanisms. It is better aligned with programs already oriented toward a defined therapeutic candidate, device concept, or development plan that need specific preclinical steps completed.
What does "R21" mean in this context?
The FOA uses the NIH Exploratory/Developmental R21 mechanism, which is commonly used for early-stage, milestone-oriented projects intended to generate critical feasibility or development-enabling data.
What is the maximum award amount (award ceiling)?
The award ceiling listed is $200,000.
How much total funding did NIH expect to commit each year?
The agencies anticipated committing about $1,000,000 per year total to support meritorious applications, with the exact number and size of awards depending on submission quality, proposed duration, and requested budgets.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
What is the funding instrument and funding category?
The opportunity is categorized as discretionary funding and uses the grant funding instrument.
What is the activity category for this opportunity?
The activity category is health.
What CFDA numbers are associated with this FOA?
The CFDA numbers associated with the participating NIH programs are 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Who is eligible to apply?
Eligibility is broad and includes many organization types, including:
- Nonprofit organizations (with or without 501(c)(3) status)
- Public and private institutions of higher education
- For-profit organizations (including small businesses and other than small businesses)
- Government entities (state, county, city/township, special district governments, and independent school districts)
- Public housing authorities / Indian housing authorities
- Federally recognized tribal governments and other tribal entities
- Tribally controlled colleges and universities
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving institutions
- Historically Black Colleges and Universities (HBCUs)
- Faith-based or community-based organizations
- Eligible federal agencies
- Regional organizations
- Non-U.S. (foreign) entities
- U.S. territories or possessions
Are for-profit organizations allowed to apply?
Yes. The eligibility list includes for-profit organizations, including small businesses and other than small businesses.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA notes eligibility for non-U.S. (foreign) entities.
Are tribal entities and tribally controlled institutions eligible?
Yes. The FOA includes eligibility for federally recognized and other tribal entities and tribally controlled colleges and universities.
Are institutions serving specific populations (for example HBCUs or Hispanic-serving institutions) eligible?
Yes. The FOA lists eligible applicants that include HBCUs, Hispanic-serving institutions, as well as Alaska Native and Native Hawaiian Serving Institutions.
Is this FOA currently active?
No. The administrative record indicates the FOA is no longer active. It lists an original and current closing date of September 7, 2011 and an archive date of October 8, 2011.
When was the FOA posted and when did it close?
The FOA was posted on August 5, 2008. The listed closing date is September 7, 2011. The archive date is October 8, 2011.
Where was the full announcement hosted?
The full announcement was hosted through the NIH grants website at the link provided in the source record.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What does the FOA expect after a successful R21 project?
The FOA expects that a successful R21 will place the therapeutic program in a position to proceed into a subsequent effort focused on completing the remaining work to support an IND (drugs/biologics) or an IDE (devices).
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 08 228) also looked into and applied for these:
| Funding Opportunity |
|---|
| Translational Research at the Aging/Cancer Interface (TRACI) (R01) Apply for PA 08 230 Funding Number: PA 08 230 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Translational Research at the Aging/Cancer Interface (TRACI) (R21) Apply for PA 08 231 Funding Number: PA 08 231 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| NINDS Exploratory/Developmental Projects in Translational Research (R21) Apply for PAR 08 232 Funding Number: PAR 08 232 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Aging Research Dissertation Awards to Increase Diversity (R36) Apply for PAR 08 250 Funding Number: PAR 08 250 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Archiving and Development of Socialbehavioral Datasets in Aging Related Studies (R03) Apply for PA 08 252 Funding Number: PA 08 252 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Functioning of People with Mental Disorders (R01) Apply for PA 08 255 Funding Number: PA 08 255 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The Effects of Alcohol on Glial Cells (R01) Apply for RFA AA 09 003 Funding Number: RFA AA 09 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The Effects of Alcohol on Glial Cells (R21) Apply for RFA AA 09 004 Funding Number: RFA AA 09 004 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Follow up Public Consultation to Inform the Design of a Possible Longitudinal Cohort Study of the Role of Genes and Environment in Health and Disease Limited Competition (U01) Apply for RFA HG 09 004 Funding Number: RFA HG 09 004 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| National Institute of Mental Health (NIMH) Career Opportunities in Research (COR) Honors Undergraduate Research Training Grant (T34) Apply for PAR 08 093 Funding Number: PAR 08 093 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Researching Implementation and Change while Improving Quality (R18) Apply for PAR 08 136 Funding Number: PAR 08 136 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| NEI CAREER TRANSITION AWARD (K22) Apply for PAR 04 136 Funding Number: PAR 04 136 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Career Development Award to Promote Diversity in Neuroscience Research Apply for PAR 05 071 Funding Number: PAR 05 071 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| AHRQ Mentored Clinical Scientist Development Award (K08) Apply for PAR 07 443 Funding Number: PAR 07 443 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| AHRQ Independent Scientist Award (K02) Apply for PAR 07 444 Funding Number: PAR 07 444 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| AHRQ Mentored Research Scientist Development Award (K01) Apply for PAR 08 022 Funding Number: PAR 08 022 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Academic Career Award (K07) Apply for PA 08 152 Funding Number: PA 08 152 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Promoting Careers In Aging and Health Disparities Research (K01) Apply for PAR 08 033 Funding Number: PAR 08 033 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Neurological Sciences Academic Development Award (NSADA) (K12) Apply for PAR 08 197 Funding Number: PAR 08 197 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Innovative Patient Outreach Programs and Ocular Screening Technologies to Improve Detection of Diabetic Retinopathy (SBIR R43/R44) Apply for RFA EY 09 001 Funding Number: RFA EY 09 001 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
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