Opportunity Information: Apply for RFA DA 11 012
Apply for RFA DA 11 012
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Exploring Human Induced Pluripotent Stem Cells for Substance Abuse Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Jan 4, 2011 and posted on Jan 4, 2011.
- Applicants must submit their applications by Mar 31, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments Special district governments Independent school districts Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Native American tribal governments (Federally recognized) Small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The grant opportunity titled "Exploring Human Induced Pluripotent Stem Cells for Substance Abuse Research (R21)" (Funding Opportunity Number RFA-DA-11-012) is a National Institutes of Health (NIH) discretionary grant that was designed to push forward practical, research-ready ways to use human induced pluripotent stem cells (iPSCs) in the study of drug abuse and addiction. The core goal is methodological and standard-setting rather than testing a single drug or hypothesis: it invites applicants to create, optimize, and standardize reliable methods for generating specific human cell types from iPSCs that are especially relevant to substance use research, with examples including neuronal and glial cells. In other words, the program is focused on building and validating the lab tools and cellular models that can later be used to investigate how substances affect the human nervous system, why certain individuals may be more vulnerable, and how addiction-related biology unfolds at the cellular level.
This FOA uses the R21 mechanism, which is commonly used by NIH to support exploratory and developmental projects where early-stage, high-impact groundwork is needed. Here, that exploratory emphasis fits the stated purpose: developing robust differentiation protocols, improving consistency across laboratories, and establishing standardized approaches to produce brain-relevant human cell populations derived from iPSCs. By prioritizing the generation of neuronal and glial cells, the announcement signals an interest in modeling the cell types most closely tied to neural signaling, plasticity, neuroinflammation, and other processes that are central to substance use disorders. The intended payoff is to expand the field's ability to study addiction biology in human-derived systems that can complement animal models and help bridge gaps between preclinical findings and human outcomes.
From an administrative and funding perspective, the opportunity falls under the Health and Education activity categories and is associated with CFDA number 93.279 (Drug Abuse and Addiction Research Programs). The estimated total funding amount listed for the FOA is $1,500,000, and the award ceiling is $200,000. There is no cost sharing or matching requirement, which reduces barriers for organizations that may not have discretionary funds to contribute and aligns with typical NIH research grant structures.
Eligibility for this FOA is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include state, county, city or township governments; special district governments; and public housing authorities/Indian housing authorities. Academic eligibility spans both public/state controlled and private institutions of higher education, as well as independent school districts in the listed eligibility categories. The FOA also allows applications from nonprofit organizations (both those with and without 501(c)(3) status) and from for-profit organizations (other than small businesses), while small businesses are also explicitly listed as eligible. Tribal entities are included in multiple forms, including federally recognized Native American tribal governments and other tribal organizations. The additional eligibility information further extends the pool to include Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and foreign organizations/non-U.S. entities. Taken together, the eligibility language suggests NIH wanted to attract a wide range of technical expertise, including stem cell biology, neuroscience, addiction science, and protocol development, without restricting participation to a narrow institutional type.
Timing details indicate this was a time-limited solicitation. The FOA was posted and created on January 4, 2011, with an original and current closing date of March 31, 2011, and an archive date of May 1, 2011. That means the competition window was relatively short and the opportunity is now archived, but the content remains useful as a snapshot of NIH priorities at the time and as a template for what similar NIH method-development opportunities tend to emphasize.
For applicants who needed the full announcement, the FOA provided an official NIH link to the complete notice (http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-012.html). Contact support listed in the source data focuses on access and technical issues with the online announcement, directing users to the NIH Office of Extramural Research (OER) webmaster addresses for troubleshooting.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Exploring Human Induced Pluripotent Stem Cells for Substance Abuse Research (R21)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-11-012.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What is the main purpose of this FOA?
The core purpose is to push forward practical, research-ready ways to use human induced pluripotent stem cells (iPSCs) in drug abuse and addiction research by creating, optimizing, and standardizing reliable methods to generate specific human cell types from iPSCs that are especially relevant to substance use research.
Is this FOA focused on testing a specific drug or hypothesis?
No. The emphasis is methodological and standard-setting rather than testing a single drug or a single biological hypothesis.
What kinds of work does the FOA encourage?
It encourages developing, optimizing, and standardizing robust iPSC differentiation methods and approaches, improving consistency across laboratories, and establishing standardized approaches to produce brain-relevant human cell populations derived from iPSCs.
What cell types are specifically highlighted as relevant examples?
Examples mentioned include neuronal and glial cells.
Why are neuronal and glial cells emphasized?
Because these cell types are closely tied to neural signaling, plasticity, neuroinflammation, and other processes central to substance use disorders, and they are particularly useful for building human-derived cellular models relevant to addiction biology.
What is the intended payoff or longer-term impact of this FOA?
The intended payoff is to expand the field's ability to study addiction biology in human-derived systems that can complement animal models and help bridge gaps between preclinical findings and human outcomes.
What grant mechanism does this FOA use?
This FOA uses the NIH R21 mechanism.
What does the R21 mechanism imply about project scope or stage?
R21 awards are commonly used by NIH to support exploratory and developmental projects where early-stage, high-impact groundwork is needed. In this FOA, that aligns with developing and validating tools, methods, and standardized protocols.
What activity categories are associated with this opportunity?
The opportunity falls under the Health and Education activity categories.
What is the CFDA number associated with this FOA?
The CFDA number is 93.279 (Drug Abuse and Addiction Research Programs).
How much total funding was estimated for this FOA?
The estimated total funding amount listed is $1,500,000.
What is the award ceiling?
The award ceiling is $200,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include various government entities, academic institutions (public and private), nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and tribal entities (including federally recognized tribal governments and other tribal organizations).
Are state and local government entities eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities.
Are colleges and universities eligible?
Yes. Eligibility includes public/state controlled institutions of higher education and private institutions of higher education.
Are independent school districts eligible?
Yes. Independent school districts are included in the listed eligibility categories.
Are nonprofits eligible even if they do not have 501(c)(3) status?
Yes. Nonprofit organizations with and without 501(c)(3) status are listed as eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also explicitly listed as eligible.
Are tribal organizations eligible?
Yes. Tribal entities are included, including federally recognized Native American tribal governments and other tribal organizations.
Does the FOA include institution types such as HBCUs, HSIs, and TCCUs?
Yes. Additional eligibility information extends to Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included in the additional eligibility information.
Are regional organizations eligible?
Yes. Regional organizations are included in the additional eligibility information.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are included in the additional eligibility information.
Are U.S. territories or possessions included in eligibility?
Yes. U.S. territories or possessions are included in the additional eligibility information.
Are foreign or non-U.S. organizations eligible to apply?
Yes. The eligibility language includes foreign organizations and non-U.S. entities.
When was this FOA posted and created?
The FOA was posted and created on January 4, 2011.
What was the closing date for applications?
The original and current closing date was March 31, 2011.
Is this funding opportunity still active?
No. The opportunity is archived. The archive date is May 1, 2011.
Where can applicants find the official FOA text?
The FOA points to the official NIH notice at http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-012.html.
Who should be contacted for technical issues accessing the online announcement?
Support listed focuses on access and technical issues with the online announcement, directing users to the NIH Office of Extramural Research (OER) webmaster addresses for troubleshooting.
What research area does this FOA align with?
It aligns with drug abuse and addiction research, specifically the development of iPSC-derived human cellular models (such as neuronal and glial cells) and standardized methods to support substance use research.
Browse more opportunities from the same category: Education Health
Next opportunity: Rural Access to Emergency Devices
Previous opportunity: NHLBI Investigator Initiated Resource Related Research Projects (R24)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DA 11 012
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DA 11 012) also looked into and applied for these:
| Funding Opportunity |
|---|
| Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R01) Apply for RFA NR 11 003 Funding Number: RFA NR 11 003 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R21) Apply for RFA NR 11 004 Funding Number: RFA NR 11 004 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Acute Life Threatening Conditions and Opportunities for Palliative and End of Life Care Research (R01) Apply for RFA NR 11 008 Funding Number: RFA NR 11 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Interdisciplinary Approaches for HIV/AIDS Risk Avoidance Decision Making in Developing Adolescents (R01) Apply for RFA NR 11 007 Funding Number: RFA NR 11 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Alzheimers Disease Pilot Clinical Trials (R01) Apply for PAR 11 100 Funding Number: PAR 11 100 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| U.S. India Bilateral Brain Research Collaborative Partnerships (U.S. India BRCP) (R21) Apply for PAR 11 099 Funding Number: PAR 11 099 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Increasing Opportunities in Advanced Heart Failure and Palliative Care Research (R01) Apply for RFA NR 11 006 Funding Number: RFA NR 11 006 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Reducing Health Disparities Among Minority and Underserved Children (R01) Apply for PA 11 104 Funding Number: PA 11 104 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R21) Apply for PA 11 105 Funding Number: PA 11 105 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Lasker Clinical Research Scholars Program (SI2) Apply for RFA OD 11 001 Funding Number: RFA OD 11 001 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Pre Application for the 2011 NIDA Translational Avant Garde Award for Medication Development for Diseases of Addiction (X02) Apply for PAR 11 102 Funding Number: PAR 11 102 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| 2011 NIDA Translational Avant Garde Award for Medication Development for Diseases of Addiction (DP1) Apply for RFA DA 11 009 Funding Number: RFA DA 11 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer Therapeutics, Imaging Technologies, Interventional Devices, Diagnostics, and Prognostics Toward Commercialization (R44) Apply for RFA CA 11 002 Funding Number: RFA CA 11 002 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
| Predictive Animal Models for Smoking Cessation Medications (U54) Apply for RFA DA 11 014 Funding Number: RFA DA 11 014 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Centers for AIDS Research and Developmental Centers for AIDS Research (P30) Apply for PAR 11 108 Funding Number: PAR 11 108 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Grand Opportunity in Medications Development for Substance Related Disorders (U01) Apply for PAR 11 109 Funding Number: PAR 11 109 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31) Apply for PA 11 111 Funding Number: PA 11 111 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NINR Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows In Nursing Research (F31) Apply for PAR 11 117 Funding Number: PAR 11 117 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Limited Competition Specific pathogen free macaque colonies (U42) Apply for PAR 11 116 Funding Number: PAR 11 116 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Limited Competition Specific pathogen free macaque colonies (U24) Apply for PAR 11 115 Funding Number: PAR 11 115 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DA 11 012", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.