Opportunity Information: Apply for RFA RM 15 007
Apply for RFA RM 15 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jul 14, 2015 and posted on Jul 14, 2015.
- Applicants must submit their applications by Oct 15, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) City or township governments Private institutions of higher education Special district governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity "Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01)" (Funding Opportunity Number RFA-RM-15-007) is a National Institutes of Health (NIH) Common Fund initiative under the program area Accelerating Translation of Glycoscience: Integration and Accessibility. Its central purpose is to push glycoscience forward by making carbohydrate-focused research more practical for the broader biomedical community, not just for specialized carbohydrate chemistry labs. The underlying idea is that carbohydrates (often referred to as glycans, and when attached to other molecules as glycoconjugates) play major roles in biology, health, and disease, but they are often difficult to study because they are structurally complex and hard to make or modify in the lab. By investing in better synthesis and functionalization methods, NIH is trying to remove a major bottleneck that keeps many researchers from working with glycans at all.
Scientifically, this FOA is aimed at developing new approaches that enable the rapid, robust, and affordable synthesis and/or functionalization of biomedically relevant glycans and glycoconjugates. The methods of interest include catalytic methods, chemical methods, chemoenzymatic methods, and enabling technologies that make these processes easier, more reliable, and more scalable. The targets are explicitly framed around two broad biological categories: (1) mammalian glycomes, meaning the diverse set of glycan structures found in mammals (including humans), and (2) microbial glycans, meaning carbohydrate structures produced by microbes that often matter for infection, immunity, and host-microbe interactions. In practice, the sought-after outcomes are tool-like advances that allow researchers to obtain defined glycan structures more quickly and at lower cost, to derivatize or functionalize them in useful ways (for example, to attach probes, tags, or handles for downstream experiments), and to do so with a level of reproducibility that supports widespread adoption.
From a program and funding standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism (U01). That mechanism typically signals substantial NIH scientific or programmatic involvement during the project period compared to a standard research grant, with the goal of keeping projects aligned with shared program milestones and deliverables. The FOA anticipated making about 6 awards, with an estimated total funding amount of $4,000,000 and an award ceiling of $500,000. The activity category is listed as Health, and the CFDA number referenced is 93.310 (Trans-NIH Research Support). Cost sharing or matching is not required.
Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, for-profit organizations (including those that are not small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and special district governments. The FOA also notes additional categories considered eligible, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. However, foreign components (as defined by NIH policy) are allowed, which generally means a U.S. applicant can include certain foreign collaborations or performance sites if justified and compliant with NIH rules.
Key dates show this announcement was posted and created on July 14, 2015, with an original and current closing date of October 15, 2015, and an archive date of November 15, 2015. Operationally, that means it was a time-limited call intended to fund a specific set of projects to build the glycoscience toolkit, rather than a continuously open, standard NIH parent announcement.
Overall, the FOA is best understood as an infrastructure-and-enabling-technology push: it is not simply asking for biological discoveries about glycans, but for new synthetic capabilities and practical technologies that make it easier for non-specialists to access high-quality, well-defined mammalian and microbial glycans and glycoconjugates. By lowering technical barriers around glycan synthesis and modification, the program aims to expand who can do glycoscience and speed up how quickly glycan-related biology can be tested in mainstream biomedical research. For full details, NIH referenced the official announcement page at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-15-007.html, and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
FAQs: Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01) (RFA-RM-15-007)
What is this funding opportunity?
This opportunity is titled "Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01)" and is identified by Funding Opportunity Number RFA-RM-15-007. It is an NIH Common Fund initiative under the program area "Accelerating Translation of Glycoscience: Integration and Accessibility."
What is the main goal of the FOA?
The central goal is to advance glycoscience by making carbohydrate-focused research more practical and accessible to the broader biomedical research community, not only to specialized carbohydrate chemistry laboratories. The program aims to remove a major barrier to working with glycans by improving how they are synthesized and functionalized.
Why is NIH emphasizing carbohydrates (glycans) in biomedical research?
The FOA is based on the premise that carbohydrates (often called glycans, and glycoconjugates when attached to other molecules) play major roles in biology, health, and disease, but are frequently difficult to study because they are structurally complex and hard to make or modify in the lab. Better synthesis and functionalization methods are intended to make glycan-related research more feasible for many more investigators.
What types of research projects does the FOA seek to support?
The FOA focuses on developing new approaches for the rapid, robust, and affordable synthesis and/or functionalization of biomedically relevant glycans and glycoconjugates. The emphasis is on practical, enabling advances that can be adopted broadly.
Is this FOA focused on biological discovery, or on tools and methods?
It is primarily an infrastructure-and-enabling-technology effort. Rather than simply funding biological discoveries about glycans, it seeks new synthetic capabilities and practical technologies that allow non-specialists to access defined, high-quality glycans and glycoconjugates.
What kinds of synthesis or functionalization methods are of interest?
The FOA highlights catalytic methods, chemical methods, chemoenzymatic methods, and enabling technologies that make synthesis and modification easier, more reliable, and more scalable.
What does "functionalization" mean in the context of this FOA?
Within the FOA description, functionalization refers to derivatizing or modifying glycans and glycoconjugates in useful ways, such as attaching probes, tags, or handles for downstream experiments.
What biological targets are in scope?
The targets are framed around two broad categories: (1) mammalian glycomes (the diverse set of glycan structures found in mammals, including humans) and (2) microbial glycans (carbohydrate structures produced by microbes that are relevant to infection, immunity, and host-microbe interactions).
What kinds of outcomes is NIH looking for?
The desired outcomes are tool-like advances that let researchers obtain defined glycan structures faster and at lower cost, and to modify them in practical ways, with reproducibility strong enough to support widespread adoption by the broader biomedical community.
What is the funding mechanism for this opportunity?
The FOA uses a cooperative agreement mechanism (U01). This mechanism generally indicates substantial NIH scientific or programmatic involvement during the project period compared to a standard research grant, with the intent of keeping funded projects aligned with shared milestones and deliverables.
How many awards were anticipated?
The FOA anticipated making about 6 awards.
What was the estimated total funding amount?
The estimated total funding amount was $4,000,000.
What was the award ceiling?
The award ceiling listed was $500,000.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
What is the activity category and CFDA number listed?
The activity category is listed as Health, and the CFDA number referenced is 93.310 (Trans-NIH Research Support).
Who is eligible to apply?
Eligibility is broad across many U.S.-based organization types. The FOA lists public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, for-profit organizations (including those that are not small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and special district governments.
Are specific institution types explicitly included as eligible?
Yes. The FOA also notes additional categories considered eligible, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply under this FOA.
Are non-U.S. components of U.S. organizations eligible?
No. The FOA states that non-U.S. components of U.S. organizations are also not eligible.
Are foreign collaborations allowed in any form?
Yes, foreign components (as defined by NIH policy) are allowed. This generally means a U.S. applicant may include certain foreign collaborations or performance sites if they are justified and compliant with NIH rules, even though foreign institutions cannot apply as the primary applicant.
When was the FOA posted, and what were the key dates?
The announcement was posted and created on July 14, 2015. The original and current closing date was October 15, 2015, and the archive date was November 15, 2015.
Is this an open, ongoing NIH funding opportunity?
No. Based on the dates provided, it was a time-limited call intended to fund a specific set of projects, rather than a continuously open parent announcement.
Where can applicants find the official FOA details?
NIH referenced the official announcement page at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-15-007.html.
Who was listed for help with access or linking issues?
The FOA notes NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
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