Opportunity Information: Apply for PA 12 227
Apply for PA 12 227
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Fatigability, Activity Limitations, and Bioenergetics in Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jul 11, 2012 and posted on Jul 11, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts For profit organizations other than small businesses Special district governments County governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed
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Opportunity Summary:
The Fatigability, Activity Limitations, and Bioenergetics in Aging (R01) opportunity (Funding Opportunity Number PA-12-227) is a National Institutes of Health (NIH) discretionary grant program focused on understanding and addressing “fatigability†in older adults. In this context, fatigability is not just general tiredness; it is fatigue considered alongside the level of activity being performed, which helps distinguish someone who feels exhausted after minimal effort from someone who feels similarly tired only after strenuous exertion. The overall purpose of the announcement is to encourage research that clarifies why fatigability increases with age, how it contributes to reduced activity and functional decline, and what can be done to prevent or reverse its effects in ways that matter to daily life and well-being.
The FOA invites three broad types of projects. First, applicants can propose studies that investigate how specific bioenergetic factors contribute to increased fatigability, decreased activity, and a diminished sense of well-being in older persons. “Bioenergetic factors†generally refers to the biological systems and processes that govern energy production, utilization, and efficiency in the body, including how muscles and other tissues generate and manage energy under physical or metabolic stress. This area supports mechanistic and translational work that links measurable biological pathways to real-world limitations, with the aim of explaining why some older adults become activity-limited and fatigued with relatively low levels of exertion.
Second, the FOA encourages intervention research that tests whether targeting these bioenergetic factors can improve outcomes that are meaningful for older adults. Proposed interventions can be designed to improve performance capabilities (for example, physical performance during walking or other standardized tasks), functional status (ability to perform daily activities), and broader outcomes tied to quality of life. The emphasis is on interventions that are plausibly connected to the bioenergetic contributors to fatigability, rather than interventions that only indirectly relate to the problem. In other words, applicants are encouraged to connect the “why†(bioenergetic mechanisms) to the “what works†(interventions) using rigorous study designs appropriate for an R01.
Third, the FOA supports the development and evaluation of better measures of fatigability that can be used in observational studies and/or interventional trials. Because fatigability is defined relative to activity level, measuring it well often requires tools or protocols that capture fatigue responses to standardized workloads or that validly interpret fatigue reports in relation to what a person actually did. This portion of the announcement is meant to strengthen the field by improving measurement quality, comparability across studies, and the ability to track change over time or in response to treatment.
Administratively, this is an NIH R01 grant mechanism under the health-related funding activity category, associated with CFDA 93.866 (Aging Research). Cost sharing or matching is not required. The opportunity was posted and created on July 11, 2012, with an original and current closing date listed as September 7, 2015, and an archive date of October 8, 2015, indicating it is no longer active but remains accessible for reference. The funding instrument type is listed as “Grant,†and the opportunity category is “Discretionary.â€
Eligibility is broad and includes many types of U.S. organizations such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, for-profit organizations other than small businesses, and a range of government entities (state, county, city/township, special district governments, public housing authorities, and independent school districts). The FOA also explicitly notes additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement, reflecting NIH’s willingness to support scientifically strong work regardless of geography when justified and compliant with policy.
For applicants or institutions needing the full original details, the FOA points to the NIH Grants Guide announcement page (http://grants.nih.gov/grants/guide/pa-files/PA-12-227.html). For technical issues accessing the announcement or linking to it, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Fatigability, Activity Limitations, and Bioenergetics in Aging (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-12-227.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) discretionary grant program.
What type of grant mechanism is used?
The mechanism is an NIH R01, and the funding instrument type is listed as Grant.
What is the main purpose of the FOA?
The FOA encourages research to clarify why fatigability increases with age, how it contributes to reduced activity and functional decline, and what can be done to prevent or reverse these effects in ways that meaningfully impact daily life and well-being.
How does this FOA define "fatigability"?
In this FOA, fatigability is not simply general tiredness. It is fatigue considered alongside the level of activity being performed. This helps distinguish a person who feels exhausted after minimal effort from someone who feels similarly tired only after strenuous exertion.
What broad types of projects does the FOA invite?
The FOA invites three broad project types: (1) studies on how specific bioenergetic factors contribute to fatigability and activity limitations in older adults, (2) intervention research targeting bioenergetic factors to improve meaningful outcomes, and (3) development and evaluation of better measures of fatigability for observational studies and/or trials.
What kinds of bioenergetic research topics are within scope?
The FOA supports studies that examine how bioenergetic factors contribute to increased fatigability, decreased activity, and diminished well-being in older persons. Bioenergetic factors refer to biological systems and processes governing energy production, utilization, and efficiency, including how muscles and other tissues generate and manage energy under physical or metabolic stress.
Does the FOA support mechanistic or translational work?
Yes. The FOA supports mechanistic and translational work that links measurable biological pathways to real-world limitations, with the goal of explaining why some older adults become activity-limited and fatigued at relatively low exertion levels.
What types of interventions are encouraged?
The FOA encourages intervention research that tests whether targeting bioenergetic factors can improve outcomes meaningful for older adults, including performance capabilities (for example, walking or other standardized tasks), functional status (ability to perform daily activities), and broader quality-of-life-related outcomes.
Is it important to connect interventions to bioenergetic mechanisms?
Yes. The FOA emphasizes interventions that are plausibly connected to bioenergetic contributors to fatigability, rather than approaches that only indirectly relate. Applicants are encouraged to connect the "why" (mechanisms) to "what works" (interventions) using rigorous R01-appropriate study designs.
What measurement-related work does the FOA support?
The FOA supports developing and evaluating better measures of fatigability for observational studies and/or interventional trials, especially tools or protocols that capture fatigue responses to standardized workloads or interpret fatigue reports in relation to what a person actually did.
Why is measurement of fatigability a focus area?
Because fatigability is defined relative to activity level, measuring it well often requires approaches that account for the workload or activity context. This area is intended to improve measurement quality, increase comparability across studies, and strengthen the ability to track change over time or in response to treatment.
What is the associated CFDA number and topic area?
The program is associated with CFDA 93.866, which is Aging Research.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
What is the opportunity category?
The opportunity category is listed as Discretionary.
Is this funding opportunity currently active?
No. The FOA shows an original and current closing date of September 7, 2015 and an archive date of October 8, 2015, indicating it is no longer active and is available for reference.
When was the opportunity posted/created?
The opportunity was posted and created on July 11, 2012.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations, including public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations other than small businesses, and government entities such as state, county, city/township, special district governments, public housing authorities, and independent school districts.
Are minority-serving and community-based institutions included in the eligibility list?
Yes. The FOA explicitly includes eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, among others.
Are U.S. territories or possessions eligible?
Yes. The FOA states that U.S. territories or possessions are eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies among the eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA states that non-U.S. entities (foreign institutions) are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA states that non-U.S. components of U.S. organizations are eligible.
Are foreign components permitted under this FOA?
Yes. The FOA notes that foreign components are allowed as defined in the NIH Grants Policy Statement.
Where can applicants find the full FOA text?
The FOA points to the NIH Grants Guide announcement page at: http://grants.nih.gov/grants/guide/pa-files/PA-12-227.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing the announcement or linking to it, the FOA lists the NIH Office of Extramural Research (OER) Webmaster: FBOWebmaster@OD.NIH.GOV.
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