Opportunity Information: Apply for PA 12 225
Apply for PA 12 225
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Fatigability, Activity Limitations, and Bioenergetics in Aging (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jul 11, 2012 and posted on Jul 11, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments City or township governments County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity "Fatigability, Activity Limitations, and Bioenergetics in Aging (R21)" (Funding Opportunity Number PA-12-225) is a discretionary research grant announcement focused on understanding and addressing fatigability in older adults. In this context, fatigability is not just general tiredness; it is defined as fatigue that is interpreted relative to a person s activity level, meaning the same feeling of fatigue can have very different implications depending on what someone is doing and what they are capable of doing. The overall aim is to improve scientific understanding of why older people may experience increased fatigability, how that relates to reduced physical activity and diminished well-being, and how researchers can measure and potentially mitigate these problems in ways that matter for everyday functioning and quality of life.
The FOA invites exploratory and developmental (R21) applications that fit into one or more of three main directions. First, applicants may propose studies that investigate how specific bioenergetic factors contribute to increased fatigability, lower activity levels, and reduced sense of well-being in aging populations. "Bioenergetic factors" broadly refers to the biological processes involved in producing and using energy, which can include cellular and mitochondrial energy production, metabolic efficiency, oxygen utilization, and related physiological pathways that influence how much effort an activity requires and how quickly fatigue develops. Second, applicants may test interventions designed to target those bioenergetic factors, with the goal of improving outcomes such as performance capacity, functional status, and other endpoints tied to quality of life. These interventions could be behavioral, pharmacologic, nutritional, device-based, rehabilitative, or otherwise, as long as they are aimed at mechanisms plausibly connected to bioenergetics and fatigability and the study is designed to assess impacts on meaningful function. Third, the FOA encourages development and evaluation of measures of fatigability that can be used in observational studies and or intervention trials, recognizing that high-quality measurement is often a limiting factor in this field. That measurement emphasis signals interest in tools that are practical, valid, reliable, sensitive to change, and interpretable across differing activity levels and populations of older adults.
As an R21 mechanism, the opportunity is intended to support early-stage, innovative, and potentially high-impact projects, including pilot work that generates feasibility data, develops new methods, or opens new lines of inquiry rather than large definitive trials. The award ceiling listed for the FOA is 200,000, and there is no cost sharing or matching requirement. The activity category is Health and it is associated with CFDA number 93.866, Aging Research, placing it squarely within NIH supported aging and geriatrics related science.
Eligibility for this grant is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses, for-profit entities other than small businesses, independent school districts, and a wide range of government entities such as state, county, city or township, special district governments, and certain housing authorities. Tribal governments and tribal organizations are eligible, including federally recognized tribal governments as well as other tribal entities. The FOA also explicitly lists additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, foreign institutions and other non-U.S. entities are also eligible to apply, and non-U.S. components of U.S. organizations may participate; foreign components are allowed as defined by NIH policy, which can be significant for research teams with international cohorts, specialized measurement platforms, or collaborative bioenergetics expertise.
From an administrative standpoint, the opportunity was posted on July 11, 2012, with an original and current closing date of September 7, 2015, and it was archived on October 8, 2015. While the specific FOA is no longer open, the description provides a clear picture of NIH programmatic priorities at the time: linking the biology of energy production and utilization to real-world functional limitations in aging, identifying modifiable targets for interventions, and strengthening the way fatigability is quantified so that studies can more accurately connect mechanisms to outcomes that matter to older adults.
The official announcement link provided is http://grants.nih.gov/grants/guide/pa-files/PA-12-225.html, and NIH Office of Extramural Research contact information is included for technical access or linking issues (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH "Fatigability, Activity Limitations, and Bioenergetics in Aging (R21)" (PA-12-225)
What is this funding opportunity?
This is an NIH discretionary research grant announcement titled "Fatigability, Activity Limitations, and Bioenergetics in Aging (R21)" with Funding Opportunity Number PA-12-225. It supports exploratory and developmental research (R21) focused on understanding and addressing fatigability in older adults, particularly how biological energy processes relate to real-world function, activity, and well-being.
What does "fatigability" mean in this FOA?
In this FOA, fatigability is not the same as general tiredness. It is defined as fatigue interpreted relative to a person's activity level. The same feeling of fatigue can mean very different things depending on what activity someone is doing and what their baseline capability is.
What is the main goal of the FOA?
The overall aim is to improve scientific understanding of why older people may experience increased fatigability, how that relates to reduced physical activity and diminished well-being, and how researchers can measure and potentially mitigate these problems in ways that matter for everyday functioning and quality of life.
What type of grant mechanism is used?
The FOA uses the NIH R21 mechanism, which is intended for exploratory and developmental projects. It is generally suited for early-stage, innovative, and potentially high-impact studies, including pilot work, feasibility studies, and development of new methods rather than large definitive trials.
What research directions does the FOA encourage?
The FOA invites R21 applications that fit into one or more of three main directions: (1) studies of bioenergetic factors that contribute to increased fatigability and related outcomes in aging, (2) interventions that target bioenergetic factors to improve functional and quality-of-life endpoints, and (3) development and evaluation of measures of fatigability for use in observational studies and/or intervention trials.
What are "bioenergetic factors" in the context of this opportunity?
"Bioenergetic factors" broadly refers to biological processes involved in producing and using energy. Examples described in the FOA include cellular and mitochondrial energy production, metabolic efficiency, oxygen utilization, and related physiological pathways that influence how much effort an activity requires and how quickly fatigue develops.
What kinds of outcomes is the FOA trying to connect to bioenergetics and fatigability?
The FOA emphasizes links between bioenergetic factors and outcomes such as increased fatigability, lower activity levels, reduced sense of well-being, performance capacity, functional status, and endpoints tied to everyday functioning and quality of life.
Are intervention studies allowed, and what kinds of interventions are in scope?
Yes. The FOA specifically encourages testing interventions designed to target bioenergetic factors, with the goal of improving outcomes like performance capacity, functional status, and other quality-of-life related endpoints. Interventions may be behavioral, pharmacologic, nutritional, device-based, rehabilitative, or other types, as long as they plausibly target mechanisms connected to bioenergetics and fatigability and the study assesses impacts on meaningful function.
Does the FOA support measurement and tool development?
Yes. A major emphasis is development and evaluation of measures of fatigability for use in observational research and/or intervention trials. The FOA highlights that measurement quality can limit progress in this area and signals interest in tools that are practical, valid, reliable, sensitive to change, and interpretable across differing activity levels and across older adult populations.
Is this intended for large clinical trials?
No. The R21 mechanism described here is positioned for exploratory and developmental work (for example, feasibility data, new methods, pilot studies, or opening new lines of inquiry) rather than large, definitive trials.
What is the award ceiling for this FOA?
The award ceiling listed for the FOA is 200,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the activity category and CFDA number associated with this opportunity?
The activity category is Health. The FOA is associated with CFDA number 93.866, Aging Research.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organizations. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses, for-profit entities other than small businesses, independent school districts, and multiple types of government entities (such as state, county, city or township, special district governments, and certain housing authorities). Tribal governments and tribal organizations are eligible, including federally recognized tribal governments and other tribal entities.
Are specific institution types explicitly mentioned as eligible?
Yes. The FOA explicitly lists Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Can foreign organizations apply?
Yes. The FOA states that foreign institutions and other non-U.S. entities are eligible to apply.
Can a U.S. organization include a non-U.S. component?
Yes. Non-U.S. components of U.S. organizations may participate, and foreign components are allowed as defined by NIH policy.
When was the FOA posted, and what were the key dates?
The opportunity was posted on July 11, 2012. The original and current closing date was September 7, 2015. It was archived on October 8, 2015.
Is this FOA still open for applications?
No. Based on the provided information, it is no longer open: the closing date was September 7, 2015, and it was archived on October 8, 2015.
Where is the official announcement posted?
The official announcement link provided is http://grants.nih.gov/grants/guide/pa-files/PA-12-225.html.
Who should be contacted for technical access or linking issues?
The NIH Office of Extramural Research contact listed for technical access or linking issues is FBOWebmaster@OD.NIH.GOV.
What program priorities does the FOA description highlight?
The description highlights priorities around linking the biology of energy production and utilization to real-world functional limitations in aging, identifying modifiable bioenergetic targets for interventions, and strengthening the way fatigability is quantified so studies can better connect mechanisms to outcomes that matter to older adults.
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