Opportunity Information: Apply for PA 11 067

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Focal Cognitive Deficits in CNS Disorders (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 9, 2010 and posted on Dec 9, 2010.
  • Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses State governments County governments Private institutions of higher education Public and State controlled institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The NIH grant opportunity "Focal Cognitive Deficits in CNS Disorders (R01)" (Funding Opportunity Number PA-11-067) was a discretionary research funding announcement designed to grow the evidence base around specific, well-defined cognitive problems that occur in people with central nervous system (CNS) disorders. Rather than treating cognition as a single broad outcome, the focus is on pinpointed deficits such as problems in attention, memory, executive function, language, processing speed, visuospatial skills, or other discrete cognitive domains, and then describing their underlying nature, how they present, how they change over time, and what they mean for day-to-day functioning. The announcement explicitly encourages a mix of basic and translational research, and it also welcomes intervention research aimed at preventing, reducing, or helping people compensate for these targeted cognitive deficits.

The FOA was jointly issued by the National Institute of Nursing Research (NINR) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with the Office of Behavioral and Social Sciences Research (OBSSR) participating to advance work on behavioral and social dimensions of health and illness. A key practical detail is that OBSSR participation signals programmatic interest, but only the participating NIH Institutes and Centers (the ones listed as participating in the FOA) would provide direct award funding under this announcement. In other words, applicants could align with OBSSR priorities, but funding decisions and support would come through the participating ICs.

At a high level, the opportunity was intended to support R01 projects that clarify the "types, nature, and functional consequences" of focal cognitive deficits in CNS disorders. This naturally includes research that improves measurement and characterization of these deficits, studies that connect focal deficits to underlying mechanisms or disease processes, and studies that relate specific cognitive impairments to real-world outcomes such as independent living, symptom self-management, school or work performance, social participation, caregiver burden, safety, and quality of life. Because the FOA mentions basic, translational, and intervention research, it leaves room for projects along the pipeline, from foundational studies that define and model specific impairments to applied studies that test strategies to address them in clinical or community settings.

The mechanism used was the NIH R01 (Research Project Grant), which generally supports investigator-initiated, hypothesis-driven or discovery-oriented projects of substantial scope. The announcement did not require cost sharing or matching. The activity categories listed in the source information were Education, Health, Income Security, and Social Services, reflecting the broad public impact expected from improved understanding and management of cognitive deficits tied to CNS conditions.

Eligibility under PA-11-067 was intentionally broad. Applicants could include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, state and local governments (including counties, cities/townships, special districts, and independent school districts), public housing authorities/Indian housing authorities, federally recognized Native American tribal governments and other tribal organizations, and for-profit entities (including small businesses and other for-profits). The eligibility language also explicitly referenced a range of institution types and community-linked organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. (foreign) organizations. In practice, that breadth signaled NIH interest in encouraging diverse research settings and populations, and in supporting work that could be grounded in real-world care environments and community contexts.

Administratively, the FOA was posted on December 9, 2010, with an original and current closing date of January 7, 2014, and an archive date of February 7, 2014, indicating it is no longer active. The CFDA numbers associated with the participating NIH components were 93.361 (Nursing Research) and 93.865 (Child Health and Human Development Extramural Research), which is useful for institutional tracking and for understanding the programmatic homes most closely connected to the announcement.

For reference and full details, the FOA was hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-067.html. The contact pathway included the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV) for access or linking problems, reflecting standard NIH support for navigating the online announcement.

FAQs: NIH Focal Cognitive Deficits in CNS Disorders (R01) - PA-11-067

What is the NIH grant opportunity "Focal Cognitive Deficits in CNS Disorders (R01)" (PA-11-067)?

PA-11-067 was an NIH discretionary research funding announcement that used the R01 (Research Project Grant) mechanism to support studies focused on specific, well-defined cognitive deficits seen in people with central nervous system (CNS) disorders.

What does "focal cognitive deficits" mean in this funding opportunity?

In this FOA, "focal" means targeted, discrete cognitive problems rather than global or broad cognition outcomes. Examples mentioned include attention, memory, executive function, language, processing speed, visuospatial skills, and other specific cognitive domains.

What kinds of CNS disorders were relevant to this FOA?

The announcement was framed around CNS disorders generally. It focused on the cognitive deficits that occur in people with CNS disorders, without limiting the scope in the provided description to a single diagnosis category.

What was the main purpose or goal of PA-11-067?

The goal was to grow the evidence base on the types, nature, and functional consequences of focal cognitive deficits in CNS disorders. This included describing how these deficits present, how they change over time, and what they mean for day-to-day functioning.

Did the FOA treat cognition as a single outcome measure?

No. A defining feature of this opportunity was its emphasis on moving away from cognition as one broad outcome and instead identifying and studying particular cognitive impairments in well-defined domains.

What research areas did the FOA encourage?

The FOA explicitly encouraged basic and translational research and also welcomed intervention research aimed at preventing, reducing, or helping people compensate for targeted cognitive deficits.

What kinds of research questions fit the FOA's intent?

Projects were intended to clarify the nature of focal cognitive deficits, improve measurement and characterization, link specific deficits to underlying mechanisms or disease processes, and relate discrete cognitive impairments to real-world functional outcomes.

What real-world outcomes did the FOA highlight as relevant?

The FOA highlighted functional consequences such as independent living, symptom self-management, school or work performance, social participation, caregiver burden, safety, and quality of life.

Were intervention studies allowed under this FOA?

Yes. The announcement welcomed intervention research designed to prevent, reduce, or help people compensate for focal cognitive deficits.

Was the FOA limited to clinical studies only?

No. The FOA encouraged a mix of basic and translational research, leaving room for projects across the pipeline, from foundational studies that define and model specific impairments to applied studies that test strategies in clinical or community settings.

What grant mechanism was used?

The funding mechanism was the NIH R01 (Research Project Grant), which generally supports investigator-initiated projects of substantial scope that may be hypothesis-driven or discovery-oriented.

Did this FOA require cost sharing or matching funds?

No. The announcement did not require cost sharing or matching.

Which NIH organizations issued this funding opportunity?

The FOA was jointly issued by the National Institute of Nursing Research (NINR) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

What role did OBSSR have in this FOA?

The Office of Behavioral and Social Sciences Research (OBSSR) participated to advance behavioral and social dimensions of health and illness, signaling programmatic interest.

Does OBSSR directly fund awards under this announcement?

No. OBSSR participation signaled interest, but direct award funding would come only through the participating NIH Institutes and Centers listed in the FOA.

Who could receive the award funding under PA-11-067?

Awards under this announcement would be made by the participating NIH Institutes and Centers identified in the FOA (not by OBSSR directly).

How broad was eligibility for applicants?

Eligibility was intentionally broad and included many types of organizations across academia, nonprofits, government entities, tribal organizations, and for-profit entities, as described in the FOA summary.

Were institutions of higher education eligible to apply?

Yes. Public and private institutions of higher education were eligible.

Were nonprofits eligible to apply?

Yes. Nonprofits with or without 501(c)(3) status were eligible.

Were state and local governments eligible to apply?

Yes. State and local governments were eligible, including counties, cities/townships, special districts, and independent school districts.

Were tribal governments and tribal organizations eligible to apply?

Yes. Federally recognized Native American tribal governments and other tribal organizations were included in the eligibility language.

Were for-profit organizations eligible to apply?

Yes. For-profit entities were eligible, including small businesses and other for-profits.

Were public housing authorities eligible to apply?

Yes. Public housing authorities and Indian housing authorities were included among eligible applicants.

Were specific institution types like HBCUs or Hispanic-serving institutions mentioned as eligible?

Yes. The eligibility language explicitly referenced Historically Black Colleges and Universities (HBCUs) and Hispanic-serving Institutions, among other institution types.

Were Alaska Native and Native Hawaiian Serving Institutions included?

Yes. Alaska Native and Native Hawaiian Serving Institutions were explicitly referenced.

Were Tribally Controlled Colleges and Universities (TCCUs) included?

Yes. Tribally Controlled Colleges and Universities (TCCUs) were explicitly referenced.

Were faith-based and community-based organizations eligible?

Yes. Faith-based and community-based organizations were explicitly referenced in the eligibility language.

Could U.S. territories or possessions apply?

Yes. U.S. territories or possessions were included in the eligibility language.

Could non-U.S. (foreign) organizations apply?

Yes. Non-U.S. (foreign) organizations were explicitly referenced as eligible in the provided description.

Was this FOA active indefinitely?

No. The FOA is no longer active. It was posted on December 9, 2010, had a closing date of January 7, 2014, and an archive date of February 7, 2014.

What were the important dates for PA-11-067?

Posted date: December 9, 2010. Original and current closing date: January 7, 2014. Archive date: February 7, 2014.

What CFDA numbers were associated with the participating NIH components?

The CFDA numbers listed were 93.361 (Nursing Research) and 93.865 (Child Health and Human Development Extramural Research).

What activity categories were associated with this opportunity?

The activity categories listed were Education, Health, Income Security, and Social Services, reflecting the broad public impact expected from improved understanding and management of cognitive deficits tied to CNS conditions.

Where was the official FOA posted?

The FOA was hosted through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-067.html.

Who was listed as a contact for access or linking problems with the FOA page?

The contact pathway for access or linking problems was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What is the funding opportunity number for this announcement?

The funding opportunity number was PA-11-067.

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