Opportunity Information: Apply for PA 11 069

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Focal Cognitive Deficits in CNS Disorders (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 9, 2010 and posted on Dec 9, 2010.
  • Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts County governments Small businesses City or township governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

This NIH grant opportunity, titled "Focal Cognitive Deficits in CNS Disorders (R21)" (Funding Opportunity Number PA-11-069), supports exploratory, early-stage research on specific, well-defined cognitive problems that occur in people with central nervous system (CNS) disorders. The core aim is to broaden both basic and translational science, including intervention development and testing, focused on identifying the types of focal cognitive deficits people experience, understanding how those deficits work and why they happen, and describing their real-world functional consequences. In practical terms, the FOA is looking for projects that move beyond broad or global descriptions of impairment and instead zero in on particular cognitive domains (for example, attention, executive function, memory subcomponents, language, processing speed, visuospatial skills, social cognition, or other discrete functions) and connect those deficits to day-to-day outcomes such as self-care, adherence to treatment, school or work performance, social relationships, decision-making, and overall quality of life.

The participating NIH organizations listed are the National Institute of Nursing Research (NINR) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with the Office of Behavioral and Social Sciences Research (OBSSR) joining to encourage work that incorporates behavioral and social dimensions of health and illness. OBSSR is involved as a strategic partner promoting behavioral and social science emphases, but the announcement notes that only the participating NIH Institutes and Centers provide direct funding under this FOA. The activity mechanism is the R21, which is designed for exploratory or developmental studies, often used to generate preliminary data, pilot an approach, refine measures, or test early intervention concepts that could later be scaled into larger trials or longer-term projects.

The opportunity is categorized as a discretionary grant within federal activity areas spanning education, health, income security, and social services, reflecting the broad downstream effects cognitive deficits can have on learning, functioning, and independence. The announcement does not require cost sharing or matching, which reduces barriers for applicants who may not have institutional funds to contribute. The award ceiling is listed as $200,000, signaling that proposed projects should be tightly scoped and realistic for a smaller, time-limited, proof-of-concept style effort typical of the R21 mechanism.

Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include state, county, city/township, and special district governments; federally recognized and other Native American tribal governments and organizations; public and private institutions of higher education; independent school districts; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (including faith-based and community-based organizations); for-profit organizations (including small businesses and other for-profits); U.S. territories or possessions; and foreign organizations and other non-U.S. entities. The FOA also explicitly highlights eligibility for institutions that serve specific populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions, which may be relevant for projects addressing cognitive outcomes in underserved or disproportionately affected communities.

In terms of timing and administrative details, this FOA was posted on December 9, 2010, with an original and final closing date of January 7, 2014, and it was archived on February 7, 2014. While the dates indicate the specific announcement is no longer active, the summary still captures the funding priorities and scientific scope NINR, NICHD, and OBSSR were emphasizing: precise characterization of focal cognitive deficits in CNS disorders, translation of that knowledge into practical measurement or intervention strategies, and clear linkage between cognitive changes and functional, behavioral, and social outcomes. The official announcement link is provided through the NIH grants website, and NIH Office of Extramural Research (OER) webmaster contacts are listed for access or technical issues with the posting.

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number for this NIH grant?

The opportunity is titled "Focal Cognitive Deficits in CNS Disorders (R21)" and the Funding Opportunity Number is PA-11-069.

What is the main goal of this funding opportunity?

The core goal is to support exploratory, early-stage research that focuses on specific, well-defined cognitive problems experienced by people with central nervous system (CNS) disorders. The emphasis is on moving beyond broad descriptions of impairment and instead identifying and understanding focal cognitive deficits, why they occur, how they operate, and what real-world functional consequences they produce.

What does "focal cognitive deficits" mean in the context of this FOA?

Within this announcement, "focal" refers to research that zeroes in on particular cognitive domains or subcomponents rather than treating cognition as a single global construct. The FOA is looking for well-specified deficits (for example, a defined aspect of memory rather than "memory problems" broadly) and for projects that link those deficits to everyday functioning.

What kinds of cognitive domains does the FOA encourage applicants to study?

The FOA highlights discrete cognitive functions such as attention, executive function, memory subcomponents, language, processing speed, visuospatial skills, social cognition, and other specific cognitive functions that can be clearly defined and measured.

What types of outcomes or "real-world" consequences should projects connect to cognitive deficits?

The opportunity emphasizes tying cognitive changes to functional outcomes such as self-care, treatment adherence, school performance, work performance, social relationships, decision-making, and overall quality of life. In other words, it is not just about measuring cognitive performance, but also about demonstrating why it matters in day-to-day life.

Is the FOA focused on basic science, translational science, or interventions?

It supports a range spanning basic and translational science, including intervention development and testing, as long as the work stays anchored in specific cognitive deficits and their mechanisms and/or functional consequences.

Which NIH organizations are participating in this funding opportunity?

The participating NIH organizations listed are the National Institute of Nursing Research (NINR) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The Office of Behavioral and Social Sciences Research (OBSSR) is also involved to encourage behavioral and social dimensions within applications.

Does OBSSR provide funding under this FOA?

The announcement notes that OBSSR participates as a strategic partner to promote behavioral and social science emphases, but that only the participating NIH Institutes and Centers provide direct funding under this FOA.

What grant mechanism does this opportunity use?

This FOA uses the R21 activity mechanism, which is intended for exploratory or developmental research.

What kinds of projects are a good fit for an R21 in this FOA?

Based on the description provided, strong fits include early-stage efforts that generate preliminary data, pilot a novel approach, refine measures, or test early intervention concepts, with the expectation that promising findings could later support larger or longer-term studies.

How much funding is available per award under this FOA?

The award ceiling is listed as $200,000. This indicates projects should be tightly scoped and realistic for a smaller, proof-of-concept style award typical of the R21 mechanism.

Is cost sharing or matching required?

No. The announcement states that the FOA does not require cost sharing or matching, meaning applicants are not required to contribute institutional funds to meet a match requirement.

What federal activity areas does this opportunity fall under?

The opportunity is categorized as a discretionary grant within federal activity areas spanning education, health, income security, and social services, reflecting the broad downstream impacts that cognitive deficits can have on learning, functioning, and independence.

Who is eligible to apply?

Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants listed include:

  • State, county, city/township, and special district governments
  • Federally recognized Native American tribal governments and other tribal governments and organizations
  • Public and private institutions of higher education
  • Independent school districts
  • Public housing authorities/Indian housing authorities
  • Nonprofits with or without 501(c)(3) status (including faith-based and community-based organizations)
  • For-profit organizations (including small businesses and other for-profits)
  • U.S. territories or possessions
  • Foreign organizations and other non-U.S. entities

Are foreign (non-U.S.) organizations eligible to apply?

Yes. The eligibility list explicitly includes foreign organizations and other non-U.S. entities.

Does the FOA highlight eligibility for institutions serving specific populations?

Yes. The FOA explicitly highlights eligibility for institutions that serve specific populations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.

What is the status of this funding opportunity (is it still open)?

The FOA was posted on December 9, 2010, had an original and final closing date of January 7, 2014, and was archived on February 7, 2014. Based on these dates, this specific announcement is no longer active.

Where can applicants find the official announcement and who is listed for technical help?

The official announcement is available through the NIH grants website. For access or technical issues with the posting, the listing includes NIH Office of Extramural Research (OER) webmaster contacts.

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