Opportunity Information: Apply for RFA HG 09 004
Apply for RFA HG 09 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Follow up Public Consultation to Inform the Design of a Possible Longitudinal Cohort Study of the Role of Genes and Environment in Health and Disease Limited Competition (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 5, 2008.
- Applicants must submit their applications by Feb 3, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Small businesses Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
This funding opportunity (RFA HG 09 004) is a National Institutes of Health initiative issued by the National Human Genome Research Institute (NHGRI) to support a single follow-up project that continues and expands a prior, NHGRI-funded public consultation effort. It uses the U01 cooperative agreement mechanism, meaning the award is intended to involve substantial scientific or programmatic involvement from NIH staff in addition to the awardee's work. The overall aim is not to launch the cohort study itself, but to gather more detailed public input to help NHGRI and the broader research community think through the design of a possible large-scale, longitudinal cohort study focused on how genes and environmental factors interact to influence health and disease. In practice, this is about strengthening the ethical, legal, social, and practical foundations needed before committing to a major population study that would follow people over time and collect genetic, health, and environmental information.
The specific purpose of the follow-up consultation is to address questions and concerns that surfaced during the initial, pilot consultation study funded under RFA HG 06 008 (Public Consultation to Inform the Design of Possible Large Scale Studies of Genes and Environment in Common Disease). NHGRI is signaling that the first consultation generated important themes but also left unresolved issues that require deeper exploration. The follow-up is expected to build directly on the infrastructure, methods, relationships, and tools developed during the earlier project rather than starting from scratch. In other words, the grant is intended to leverage the prior study's groundwork (such as stakeholder networks, recruitment approaches, deliberative engagement methods, communication materials, and analysis plans) to efficiently collect additional, targeted public perspectives.
A central feature of this announcement is that it is a limited competition. Only teams connected to the previously funded RFA HG 06 008 award are eligible to apply, and the application must come from an effort that received funding support from that earlier FOA. Eligibility is extended to the Principal Investigator from the original award, any subcontract PIs, and other key participants on that award, who may apply as PI or co-PI for this follow-up. While the general eligibility list includes a wide range of organization types (public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations, small businesses, tribal governments and organizations, and certain serving institutions such as HBCUs and Hispanic-serving institutions, as well as foreign organizations and regional organizations), the limiting condition is decisive: applicants must be part of the already-funded pilot consultation project. This structure reflects the intent to maintain continuity and to avoid duplicating start-up work, since the goal is a direct follow-on rather than a brand-new line of inquiry.
Administratively, the opportunity is categorized as discretionary funding and falls under the health activity category, with CFDA number 93.172 (Human Genome Research). There is no cost sharing or matching requirement. The FOA was posted on December 5, 2008, with an original and current closing date of February 3, 2009, and it was archived on March 6, 2009. The full funding announcement is linked through the NIH Grants Guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-09-004.html. For technical issues accessing the announcement or linking to it, NIH directs applicants to the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
In plain terms, this grant is about continuing a structured public dialogue on what it would mean to run a major long-term study tracking genetic and environmental influences on disease, and doing so in a way that responds to the public concerns and open questions identified in the first round of consultation. The deliverable value is the refined, better-informed guidance that comes from deeper public engagement, which can shape decisions about study governance, participant protections, consent approaches, data use, privacy expectations, return of results, community trust, and other real-world considerations that determine whether a national-scale cohort study is feasible and socially acceptable.
Frequently Asked Questions (FAQ)
What is RFA HG 09 004?
RFA HG 09 004 is a National Institutes of Health (NIH) funding opportunity issued by the National Human Genome Research Institute (NHGRI). It supports a single follow-up project to continue and expand an earlier NHGRI-funded public consultation effort about a possible large-scale study of genes, environment, and common disease.
What is the main goal of this grant?
The goal is to gather more detailed public input to help NHGRI and the broader research community think through the design of a potential large-scale, longitudinal cohort study focused on how genes and environmental factors interact to influence health and disease. The focus is on strengthening the ethical, legal, social, and practical foundations needed before committing to a major population study.
Is this grant funding the actual large-scale cohort study?
No. The purpose is not to launch the cohort study itself. The funded work is a follow-up public consultation designed to inform and refine how such a study could be designed and governed, based on deeper exploration of public concerns and unresolved issues identified earlier.
What kind of award mechanism does this opportunity use?
This opportunity uses the U01 cooperative agreement mechanism. That means the award is intended to involve substantial scientific or programmatic involvement from NIH staff in addition to the awardee's work.
What does "cooperative agreement" mean in this context?
In this context, it means NIH staff are expected to have substantial involvement in the project beyond standard grant oversight, alongside the awardee's activities, consistent with a U01 cooperative agreement.
How many awards does NHGRI intend to make under this announcement?
The announcement is intended to support a single follow-up project.
What earlier project must applicants be connected to?
Applicants must be connected to the pilot public consultation project funded under RFA HG 06 008, titled "Public Consultation to Inform the Design of Possible Large Scale Studies of Genes and Environment in Common Disease."
Why is this described as a follow-up consultation?
NHGRI indicated that the initial pilot consultation generated important themes but also left unresolved issues. This follow-up is meant to address questions and concerns that surfaced during that first consultation and require deeper exploration.
What is meant by "limited competition" for this opportunity?
It means only teams connected to the previously funded RFA HG 06 008 award are eligible to apply, and the application must come from an effort that received funding support under that earlier funding opportunity announcement.
Who is eligible to apply as the Principal Investigator (PI) or co-PI?
Eligibility is extended to the Principal Investigator from the original RFA HG 06 008 award, any subcontract PIs, and other key participants on that award. These individuals may apply as PI or co-PI for the follow-up project.
Are organizations outside the original pilot consultation eligible if they meet general NIH eligibility rules?
The general eligibility list includes many organization types (such as universities, nonprofits, for-profits, small businesses, tribal governments and organizations, certain serving institutions, and foreign and regional organizations). However, the limiting condition is decisive: applicants must be part of the already-funded pilot consultation project under RFA HG 06 008.
Does the follow-up project need to start new infrastructure and methods?
No. The follow-up is expected to build directly on the infrastructure, methods, relationships, and tools developed during the earlier project rather than starting from scratch. The intent is to leverage prior groundwork such as stakeholder networks, recruitment approaches, deliberative engagement methods, communication materials, and analysis plans.
What kinds of issues is the follow-up consultation expected to explore?
Based on the description, the consultation is intended to produce refined guidance relevant to study design and feasibility, including considerations such as study governance, participant protections, consent approaches, data use, privacy expectations, return of results, community trust, and other real-world factors tied to whether a national-scale cohort study would be feasible and socially acceptable.
What is the overall subject area or activity category for this funding opportunity?
The opportunity falls under the health activity category and relates to human genome research.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.172 (Human Genome Research).
Is cost sharing or matching required?
No. The opportunity specifies there is no cost sharing or matching requirement.
When was the funding opportunity posted?
The FOA was posted on December 5, 2008.
What were the application closing dates?
The original and current closing date listed for the FOA is February 3, 2009.
Is this funding opportunity still active?
No. The FOA was archived on March 6, 2009.
Where can the full funding announcement be found?
The full announcement is linked through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-09-004.html
Who should be contacted for technical problems accessing the announcement link?
For technical issues accessing the announcement or linking to it, NIH directs applicants to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the key deliverable or value expected from the funded work?
The deliverable value is refined, better-informed guidance that comes from deeper public engagement. This guidance is meant to help shape decisions about how a possible large-scale longitudinal cohort study could be designed in a way that addresses public concerns and improves social acceptability and feasibility.
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