Opportunity Information: Apply for DARPA BAA 08 50

  • The DARPA Defense Sciences Office in the science and technology and other research and development sector is offering a public funding opportunity titled "Fracture Putty" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.910 Research and Technology Development.
  • This funding opportunity was created on Aug 13, 2008 and posted on Aug 13, 2008.
  • Applicants must submit their applications by Jun 4, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for DARPA BAA 08 50

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Opportunity Summary:

The Fracture Putty opportunity (Funding Opportunity Number DARPA BAA 08-50) was a DARPA Defense Sciences Office research solicitation focused on creating an advanced, dynamic biomaterial for emergency and battlefield-style orthopedic trauma care. The core idea was to develop a moldable "putty" that could be packed directly into and around a compound fracture and rapidly restore mechanical stability. Unlike traditional approaches that rely on external fixation, internal plates, or long-curing cements, DARPA was looking for a material that could deliver full load-bearing capability within hours of placement, meaning it would quickly become strong enough to support weight and functional movement after severe bone injury.

Beyond immediate stabilization, the program emphasized biological compatibility and long-term healing support. The putty was expected to form an internal structure that is osteoconductive, essentially acting like a scaffold that encourages bone cells to grow through it and lay down new bone. In practical terms, this means the material would not just "fill space" but would provide a bone-like architecture that helps the body rebuild real bone across the damaged region. The solicitation also required that the putty degrade over time into harmless, resorbable byproducts, gradually disappearing as natural bone regeneration takes over. This feature would reduce or eliminate the need for later surgical removal and aim for a smoother transition from temporary synthetic support to fully healed biological tissue.

From an administrative and funding standpoint, the opportunity was categorized as discretionary science and technology research and development under CFDA 12.910 (Research and Technology Development). DARPA indicated multiple possible award instruments, including cooperative agreements, grants, other transactions/arrangements, and procurement contracts, reflecting the agency's typical flexibility in structuring R and D efforts depending on the proposer, technical risk, and desired level of government involvement. There was no cost sharing or matching requirement listed, which generally lowers the barrier for universities, small businesses, and nontraditional performers to participate.

Eligibility was described as unrestricted, meaning the competition was open to essentially any qualified entity (such as companies, startups, universities, nonprofits, federally funded research centers, and potentially individuals or teams, subject to any clarifications in the full BAA). Interested parties were directed to the attached Broad Agency Announcement for the complete technical requirements, proposal instructions, evaluation criteria, and any constraints related to safety, testing, intellectual property, regulatory considerations, or military relevance.

Key dates show that the opportunity was posted and created on August 13, 2008, with an original and final closing date of June 4, 2009, and an archive date of July 4, 2009. Questions about accessing the full announcement were routed to the listed point of contact, Mitchell Zakin, identified as the BAA Coordinator. Overall, the solicitation reflects DARPA's interest in a fast-acting, field-deployable orthopedic repair material that combines immediate mechanical performance with a biologically supportive, resorbable scaffold to improve outcomes after complex fractures.

Fracture Putty (DARPA BAA 08-50) - Frequently Asked Questions

What is the Fracture Putty opportunity (DARPA BAA 08-50)?

The Fracture Putty opportunity (Funding Opportunity Number DARPA BAA 08-50) was a DARPA Defense Sciences Office research solicitation focused on developing an advanced, dynamic biomaterial for emergency and battlefield-style orthopedic trauma care.

What problem was DARPA trying to solve with this solicitation?

The solicitation targeted the urgent need to stabilize severe bone injuries, including compound fractures, in settings where rapid, field-deployable treatment is critical. The goal was to enable immediate or near-immediate restoration of mechanical stability so an injured limb could become functional and load-bearing much faster than traditional approaches.

What is the core concept behind the "putty"?

The core idea was a moldable material that could be packed directly into and around a compound fracture. After placement, it was expected to rapidly restore structural support, functioning as an internal stabilizer rather than relying primarily on external fixation hardware.

How quickly was the material expected to become load-bearing?

DARPA was looking for a material capable of delivering full load-bearing capability within hours of placement, meaning it would become strong enough quickly to support weight and functional movement after severe bone injury.

How was this approach different from traditional fracture stabilization methods?

Unlike traditional approaches that rely on external fixation, internal plates, or long-curing cements, the solicitation emphasized rapid mechanical stabilization from a moldable putty that could be applied directly at the injury site and become load-bearing within hours.

Did the program focus only on mechanical stabilization?

No. In addition to immediate stabilization, the program emphasized biological compatibility and support for long-term healing, including osteoconductive behavior and controlled degradation over time.

What does "osteoconductive" mean in the context of this solicitation?

In this solicitation, osteoconductive means the putty was expected to act like a scaffold that encourages bone cells to grow through it and lay down new bone. The intent was for the material to provide a bone-like architecture that supports regeneration across the damaged region.

Was the putty expected to remain in the body permanently?

No. The solicitation required that the material degrade over time into harmless, resorbable byproducts, gradually disappearing as natural bone regeneration takes over.

Why was resorbability an important requirement?

Resorbability was intended to reduce or eliminate the need for later surgical removal of the material and to support a smoother transition from temporary synthetic support to fully healed biological tissue.

What type of funding category did this opportunity fall under?

The opportunity was categorized as discretionary science and technology research and development under CFDA 12.910 (Research and Technology Development).

What award instruments could DARPA use for this opportunity?

DARPA indicated multiple possible award instruments, including cooperative agreements, grants, other transactions/arrangements, and procurement contracts, reflecting flexibility in structuring research and development efforts.

Was cost sharing or matching required?

No cost sharing or matching requirement was listed for this opportunity.

Who was eligible to apply?

Eligibility was described as unrestricted, meaning the competition was open to essentially any qualified entity. Examples mentioned include companies, startups, universities, nonprofits, federally funded research centers, and potentially individuals or teams, subject to any clarifications in the full Broad Agency Announcement (BAA).

Where would applicants find the full technical requirements and proposal instructions?

Interested parties were directed to the attached Broad Agency Announcement (BAA) for complete technical requirements, proposal instructions, evaluation criteria, and any constraints related to safety, testing, intellectual property, regulatory considerations, or military relevance.

Which DARPA office ran this solicitation?

The solicitation was run through DARPA's Defense Sciences Office.

What were the key dates for this opportunity?

The opportunity was posted and created on August 13, 2008. The original and final closing date was June 4, 2009. The archive date was July 4, 2009.

Was there more than one closing date?

Based on the information provided, the original closing date and the final closing date were the same: June 4, 2009.

Who was the point of contact for questions about the announcement?

Questions about accessing the full announcement were routed to Mitchell Zakin, identified as the BAA Coordinator.

What kind of end-use setting was the material intended for?

The program description emphasized emergency and battlefield-style orthopedic trauma care, aiming for a fast-acting and field-deployable solution.

What did DARPA mean by a "dynamic biomaterial" in this context?

Based on the description provided, "dynamic biomaterial" referred to a material that can be moldable at placement, rapidly become mechanically strong for stabilization, support bone ingrowth via an osteoconductive scaffold, and then degrade safely as healing progresses.

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