Opportunity Information: Apply for RFA RM 12 026
Apply for RFA RM 12 026
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Functional Epigenomics Developing Tools and Technologies for Cell type, Temporal, or Locus specific Manipulation of the Epigenome (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jan 4, 2013 and posted on Jan 4, 2013.
- Applicants must submit their applications by Mar 27, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $325,000.00 in funding.
- Eligible applicants include: County governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Native American tribal governments (Federally recognized) City or township governments State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-RM-12-026, titled "Functional Epigenomics Developing Tools and Technologies for Cell type, Temporal, or Locus specific Manipulation of the Epigenome (R01)," is a discretionary research grant program designed to push forward the technical side of epigenomics. Rather than focusing on a single disease area, the emphasis is on creating new research tools and enabling technologies that let scientists precisely control epigenetic states in more targeted and experimentally useful ways. The central idea is to move beyond broadly acting epigenetic drugs or nonspecific perturbations and instead support methods that can manipulate epigenetic modifications, epigenetic regulators, or their downstream effectors with much finer resolution.
The FOA is specifically looking for innovation that achieves at least one of three core capabilities, or any combination of them. First, it encourages tissue- or cell-type-specific manipulation of epigenetic modifications or the molecules that write, erase, read, or otherwise interpret epigenetic marks. This means technologies that can selectively alter epigenetic regulation in one cell population without affecting neighboring or unrelated cell types, which is especially important in complex tissues where bulk measurements and bulk interventions mask cell-to-cell differences. Second, it calls for temporal control of the epigenome, meaning approaches that allow researchers to turn epigenetic perturbations on or off at defined times, or to manipulate epigenetic states in a staged or time-resolved manner. Temporal control is critical for studying developmental processes, cellular responses to stimuli, and cause-and-effect relationships where timing determines outcomes. Third, it supports locus-specific manipulation of the epigenome, which refers to targeting epigenetic changes to particular genomic locations, such as a single promoter, enhancer, or regulatory element, rather than shifting epigenetic marks across the genome. Locus specificity enables more direct tests of how individual regulatory regions contribute to gene expression and phenotype. The FOA also explicitly welcomes approaches that combine these dimensions, such as methods that are simultaneously cell-type-specific and locus-specific, or tools that are locus-specific with time-controlled activation.
Administratively, this opportunity uses the NIH R01 grant mechanism, which is intended for substantial, hypothesis-driven or technology-development research projects. The posted date and creation date were January 4, 2013, with an original and final application due date of March 27, 2013. The announcement was archived on April 27, 2013, meaning it was active for that cycle and is now closed. The award ceiling listed is $325,000, indicating an upper bound on the amount expected or allowed under the announcement as posted in the source data.
Eligibility is broad and includes many types of domestic U.S. organizations as well as foreign entities. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses. Government entities at multiple levels are eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities or Indian housing authorities. The FOA also highlights eligibility for a wide range of mission-driven and community-linked institutions such as Historically Black Colleges and Universities, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions. Importantly, non-U.S. organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined by the NIH Grants Policy Statement, which signals openness to international tool development efforts when they align with NIH policy and scientific goals. There is no cost-sharing or matching requirement, which typically lowers barriers for applicants by not requiring institutional co-funding.
The funding activity category is health, and the CFDA listing provided is 93.310 (Trans-NIH Research Support), reflecting that the program is positioned as a cross-NIH effort rather than being tied to one specific NIH institute or center. The administering agency is the National Institutes of Health. For official details and the full announcement text, the FOA points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-026.html, and it provides an NIH Office of Extramural Research contact email (FBOWebmaster@OD.NIH.GOV) for technical access or linking issues with the electronic announcement.
Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The opportunity is NIH RFA-RM-12-026, titled "Functional Epigenomics Developing Tools and Technologies for Cell type, Temporal, or Locus specific Manipulation of the Epigenome (R01)."
What is the main goal of this FOA?
The goal is to advance the technical side of epigenomics by supporting the development of new research tools and enabling technologies that allow precise, targeted manipulation of epigenetic states. The emphasis is on methods that move beyond broadly acting or nonspecific epigenetic perturbations and instead enable finer experimental control.
Is this FOA focused on a specific disease area?
No. The FOA is not limited to a single disease area. It is positioned as a tools-and-technology program intended to enable research broadly by improving how epigenetic regulation can be manipulated and studied.
What types of innovations is the FOA specifically looking for?
The FOA seeks innovation that achieves at least one of three core capabilities (or a combination of them): (1) tissue- or cell-type-specific manipulation, (2) temporal control of epigenetic perturbations, and/or (3) locus-specific manipulation targeting defined genomic regions.
What does "cell-type-specific manipulation" mean in this FOA?
It refers to technologies that can selectively alter epigenetic modifications or the molecules that write, erase, read, or interpret epigenetic marks in a particular tissue or cell population, without affecting neighboring or unrelated cell types.
Why does the FOA emphasize cell-type-specific approaches?
Because in complex tissues, bulk measurements and bulk interventions can mask important cell-to-cell differences. Tools that work in specific cell types can provide clearer, more interpretable experimental results.
What does "temporal control" mean in this FOA?
Temporal control means having the ability to turn epigenetic perturbations on or off at defined times, or to manipulate epigenetic states in a staged or time-resolved manner.
Why is temporal control important for epigenomics research?
Timing can determine outcomes in development and in cellular responses to stimuli. Time-controlled tools can support cause-and-effect studies where it is important to know what happens when an epigenetic state is changed at a specific moment.
What does "locus-specific manipulation" mean in this FOA?
Locus-specific manipulation refers to targeting epigenetic changes to specific genomic locations, such as a single promoter, enhancer, or other regulatory element, rather than broadly shifting epigenetic marks across the genome.
Why does locus specificity matter?
It enables more direct tests of how individual regulatory regions contribute to gene expression and phenotype, because changes can be confined to defined genomic sites rather than affecting many loci at once.
Does the FOA allow approaches that combine cell-type, temporal, and locus specificity?
Yes. The FOA explicitly welcomes approaches that combine these dimensions, such as methods that are both cell-type-specific and locus-specific, or locus-specific approaches with time-controlled activation.
What kinds of biological targets or components can the tools manipulate?
Based on the FOA description, supported approaches can manipulate epigenetic modifications, epigenetic regulators (including molecules that write, erase, or read epigenetic marks), or downstream effectors that interpret epigenetic states.
What funding mechanism does this opportunity use?
This opportunity uses the NIH R01 grant mechanism.
What does it mean that the mechanism is an R01?
The R01 mechanism is intended for substantial research projects, including hypothesis-driven and technology-development efforts. In this FOA, it is used to support significant tool and technology development for functional epigenomics.
What is the award ceiling listed for this FOA?
The award ceiling listed in the provided information is $325,000.
Is this funding opportunity still open?
No. The announcement was archived on April 27, 2013, and is now closed.
When were applications due?
The original and final application due date was March 27, 2013.
When was the FOA posted?
The posted date and creation date were January 4, 2013.
Which agency administers this FOA?
The administering agency is the National Institutes of Health (NIH).
What is the funding activity category?
The funding activity category is health.
What CFDA number is associated with this opportunity?
The CFDA listing provided is 93.310 (Trans-NIH Research Support).
What does it mean that the CFDA is "Trans-NIH Research Support"?
It indicates the program is positioned as a cross-NIH effort rather than being tied to a single NIH institute or center.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and multiple levels of government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities or Indian housing authorities).
Are small businesses eligible?
Yes. Small businesses are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also separately listed as eligible.
Are nonprofit organizations eligible even if they do not have 501(c)(3) status?
Yes. Nonprofits with or without 501(c)(3) status are included in the eligibility list.
Are government entities eligible to apply?
Yes. State, county, city or township, special district governments, independent school districts, and public housing authorities or Indian housing authorities are included as eligible applicants.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA highlights eligibility for institutions including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions.
Can non-U.S. (foreign) organizations apply?
Yes. Non-U.S. organizations and foreign institutions are eligible to apply.
Can a U.S. organization apply with a non-U.S. component?
Yes. Non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined by the NIH Grants Policy Statement.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement.
Where can applicants find the official FOA text?
The FOA points to the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-026.html
Who can be contacted for technical access or linking issues with the electronic announcement?
The NIH Office of Extramural Research contact email provided for technical access or linking issues is FBOWebmaster@OD.NIH.GOV.
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