Opportunity Information: Apply for PA 07 168
Apply for PA 07 168
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Functional Genetics And Genomics Of Drug Addiction (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 14, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts State governments County governments Public and State controlled institutions of higher education Small businesses Special district governments Native American tribal governments (Federally recognized) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH grant opportunity "Functional Genetics and Genomics of Drug Addiction (R03)" (Funding Opportunity Number PA-07-168; CFDA 93.279) is aimed at moving addiction genetics beyond gene discovery and into practical biological understanding. Over the last several years, genetic and genomic studies have turned up many genes and gene variants that appear to influence vulnerability to drug abuse and addiction, but simply identifying a candidate gene or variant does not explain how it changes brain function, behavior, or risk. This announcement is designed to support basic functional genomics work that tests whether those candidates truly matter for addiction biology and, if they do, clarifies the molecular mechanisms through which they act.
Scientifically, the opportunity emphasizes two main research directions. First is functional validation: studies that determine which candidate genes and variants have an authentic causal role in addiction-related processes rather than being incidental statistical signals. This could include experiments that directly test gene function, variant impact, or gene regulation in relevant models or systems. Second is pathway and mechanism elucidation: detailed work mapping the molecular pathways, cellular processes, and biological networks influenced by those genes or variants. The announcement particularly welcomes applications that investigate genes whose role in addiction is unexpected, since these may reveal new or overlooked biological routes into addictive behavior and could open up fresh ideas for prevention or treatment targets.
The funding mechanism is the NIH Small Research Grant (R03), which is meant for small, focused projects that can be completed relatively quickly with limited resources. The FOA explicitly frames the R03 as appropriate for pilot or feasibility studies, secondary analysis of existing datasets, compact self-contained research projects, and the development of research methods or technologies relevant to functional genetics and genomics. Because it is an R03, awards are not renewable, which reinforces the idea that proposed work should be tightly scoped and achievable within the allowed timeframe and budget.
This R03 FOA is part of a coordinated set of announcements with the same scientific scope offered under larger or different mechanisms. Applicants whose projects require a bigger budget or longer timeline are pointed to parallel opportunities: an R01 version (PA-07-166) for full-scale projects and an R21 version (PA-07-167) for exploratory or developmental research. In other words, PA-07-168 targets the same core scientific goals but is intended for smaller, faster-turnaround efforts.
In terms of budget and duration, the opportunity allows up to $50,000 per year in direct costs for up to two years, for a maximum of $100,000 in direct costs across the project period. The number of awards is not fixed; funding depends on appropriations and on the volume and quality of submitted applications. There is no cost sharing or matching requirement.
Eligibility is broad and includes many common applicant types across academia, government, nonprofits, and industry. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations other than small businesses, state and local governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and special district governments. The announcement also states that foreign institutions are eligible, that eligible federal agencies may apply, and that faith-based or community-based organizations may apply, which is notable because some NIH opportunities restrict foreign or federal applicants.
Administratively, the agency is the National Institutes of Health, and the program sits within NIH's drug abuse and addiction research portfolio (CFDA 93.279). The FOA was posted on December 14, 2006, uses multiple receipt dates (meaning applications could be submitted on standard NIH receipt cycles during the active period), and was later archived on February 2, 2010. The full announcement was available through the NIH Grants Guide (link provided in the source), and NIH Office of Extramural Research support contacts were listed for technical access or linking issues.
Frequently Asked Questions (FAQs): NIH "Functional Genetics and Genomics of Drug Addiction (R03)" (PA-07-168)
What is the NIH grant opportunity PA-07-168 about?
PA-07-168, titled "Functional Genetics and Genomics of Drug Addiction (R03)," supports basic functional genomics research focused on drug abuse and addiction. Its purpose is to move beyond identifying candidate genes or variants and instead test whether they truly affect addiction biology and, if they do, explain how they influence molecular pathways, brain function, and addiction-related behaviors.
What problem is this funding opportunity trying to address?
Genetic and genomic studies have identified many genes and variants associated with vulnerability to drug abuse and addiction, but those discoveries alone do not show how the genes or variants change biology or behavior. This FOA is intended to fund studies that translate gene discovery into practical biological understanding by validating candidate findings and clarifying underlying mechanisms.
What are the main scientific priorities in this FOA?
The FOA emphasizes two primary directions: (1) functional validation, meaning experiments that determine which candidate genes and variants have a genuine causal role in addiction-related processes, and (2) pathway and mechanism elucidation, meaning detailed mapping of molecular pathways, cellular processes, and biological networks influenced by those genes or variants.
What does "functional validation" mean in the context of this announcement?
Functional validation refers to studies that test whether a candidate gene, gene variant, or regulatory element actually matters for addiction-related biology, rather than being an incidental statistical association. The FOA describes this as direct testing of gene function, variant impact, or gene regulation in relevant models or systems.
What does "pathway and mechanism elucidation" mean here?
Pathway and mechanism elucidation means research aimed at understanding how validated genes or variants exert their effects, including identifying the molecular pathways, cellular processes, and biological networks they influence in addiction-relevant contexts.
Are applications focused on unexpected genes encouraged?
Yes. The FOA particularly welcomes applications that investigate genes whose role in addiction is unexpected, because these may reveal new or overlooked biological routes into addictive behavior and may suggest new prevention or treatment targets.
What NIH funding mechanism is used for PA-07-168?
This opportunity uses the NIH Small Research Grant mechanism (R03), which is intended for small, focused projects that can be completed relatively quickly with limited resources.
What kinds of projects are considered a good fit for an R03 under this FOA?
The FOA frames the R03 as appropriate for pilot or feasibility studies, secondary analysis of existing datasets, compact self-contained research projects, and the development of research methods or technologies relevant to functional genetics and genomics of drug addiction.
Is this R03 award renewable?
No. As an R03, awards under this FOA are not renewable, which reinforces that the proposed work should be tightly scoped and achievable within the allowed budget and timeframe.
What is the maximum project period for this grant?
The FOA allows a project duration of up to two years.
What is the budget limit for PA-07-168?
The FOA allows up to $50,000 per year in direct costs for up to two years, for a maximum of $100,000 in direct costs over the project period.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
How many awards will NIH make under this opportunity?
The number of awards is not fixed. Funding depends on appropriations and on the volume and quality of submitted applications.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations other than small businesses, state and local governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and special district governments.
Are foreign institutions eligible to apply?
Yes. The FOA states that foreign institutions are eligible.
Can federal agencies apply?
Yes. The FOA indicates that eligible federal agencies may apply.
Are faith-based or community-based organizations allowed to apply?
Yes. The FOA explicitly states that faith-based or community-based organizations may apply.
What NIH program area does this FOA fall under?
The program sits within NIH's drug abuse and addiction research portfolio and is associated with CFDA 93.279.
What is the Funding Opportunity Number and CFDA number?
The Funding Opportunity Number is PA-07-168, and the CFDA number is 93.279.
When was this FOA posted, and what is its current status?
The FOA was posted on December 14, 2006, and it was later archived on February 2, 2010.
What does it mean that the FOA uses "multiple receipt dates"?
It means applications could be submitted on standard NIH receipt cycles during the period when the FOA was active, rather than having only a single due date.
Are there related NIH opportunities for larger or different types of projects?
Yes. This R03 FOA is part of a coordinated set of announcements with the same scientific scope offered under other mechanisms. Applicants needing a larger budget or longer timeline are pointed to an R01 version (PA-07-166) and an R21 version (PA-07-167).
How do the related R01 and R21 announcements differ from this R03?
Based on the FOA description, PA-07-168 (R03) is intended for smaller, faster-turnaround efforts. The parallel R01 (PA-07-166) is positioned for full-scale projects, and the parallel R21 (PA-07-167) is positioned for exploratory or developmental research.
Where was the full announcement published?
The full announcement was available through the NIH Grants Guide (via the link provided in the source materials for this opportunity).
Who would you contact for technical issues accessing the announcement?
The FOA notes that NIH Office of Extramural Research support contacts were listed for technical access or linking issues.
Which agency is administering this opportunity?
The administering agency is the National Institutes of Health (NIH).
Browse more opportunities from the same category: Education Health
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Previous opportunity: Research on Psychopathology In Intellectual Disabilities (Mental Retardation) (R01)
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 168) also looked into and applied for these:
| Funding Opportunity |
|---|
| Functional Genetics and Genomics of Drug Addiction (R21) Apply for PA 07 167 Funding Number: PA 07 167 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Functional Genetics And Genomics Of Drug Addiction (R01) Apply for PA 07 166 Funding Number: PA 07 166 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Pathogenesis And Treatment Of Lymphedema And Lymphatic Diseases (R01) Apply for PA 07 165 Funding Number: PA 07 165 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Studies of Energy Balance and Cancer in Humans (R01) Apply for PA 07 176 Funding Number: PA 07 176 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Memory T Lymphocytes in Cancer Immunology (R01) Apply for PA 07 255 Funding Number: PA 07 255 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Cancer Surveillance Using Health Claims Based Data (R01) Apply for PA 07 254 Funding Number: PA 07 254 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Information Technologies and the Internet in Health Services and Intervention Delivery (R01) Apply for PA 07 295 Funding Number: PA 07 295 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Epigenetic Approaches in Cancer Epidemiology (R21) Apply for PA 07 299 Funding Number: PA 07 299 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Epigenetic Approaches in Cancer Epidemiology (R01) Apply for PA 07 298 Funding Number: PA 07 298 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse Aspects of HIV/AIDS (R21) Apply for PA 07 309 Funding Number: PA 07 309 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse Aspects of HIV/AIDS (R03) Apply for PA 07 308 Funding Number: PA 07 308 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse Aspects of HIV/AIDS (R01) Apply for PA 07 307 Funding Number: PA 07 307 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research on Clinical Decision Making in Life Threatening Illness (R21) Apply for PA 07 316 Funding Number: PA 07 316 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Early Career Award in Chemistry of Drug Abuse and Addiction (ECHEM) NIDA (R03) Apply for PAS 07 327 Funding Number: PAS 07 327 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse, Risky Decision Making and HIV/AIDS (R03) Apply for PAS 07 326 Funding Number: PAS 07 326 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse, Risky Decision Making and HIV/AIDS (R01) Apply for PAS 07 324 Funding Number: PAS 07 324 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse, Risky Decision Making and HIV/AIDS (R21) Apply for PAS 07 325 Funding Number: PAS 07 325 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Academic Industrial Partnerships for Development and Validation of In Vivo Imaging Systems and Methods for Cancer Investigations (R01) Apply for PAR 07 214 Funding Number: PAR 07 214 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Research Education Grants in Drug Abuse and Addiction (R25) Apply for PAR 07 221 Funding Number: PAR 07 221 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Neuroscience Research on Drug Abuse (R01) Apply for PA 07 226 Funding Number: PA 07 226 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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