Opportunity Information: Apply for RFA DE 12 005
Apply for RFA DE 12 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Functional Restoration of Salivary Glands (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Aug 1, 2011 and posted on Aug 1, 2011.
- Applicants must submit their applications by Nov 29, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Small businesses For profit organizations other than small businesses Private institutions of higher education City or township governments Native American tribal governments (Federally recognized) County governments Public and State controlled institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The Functional Restoration of Salivary Glands (R21) funding opportunity (RFA-DE-12-005) is a National Institutes of Health grant announcement focused on jump-starting early, exploratory research aimed at restoring salivary gland function after it has been damaged. The emphasis is on high-risk, high-impact ideas at an early stage, where preliminary evidence may be limited but the potential payoff is large. The scientific scope is broad and includes multiple pathways to the same overall goal: improving or re-establishing saliva production and functional gland activity. That can involve repairing injured glands, regenerating a patient s own salivary tissue, or replacing lost function through a bioengineered salivary gland. In practical terms, the FOA is looking for studies that could break new ground or extend earlier discoveries into new directions, rather than incremental work.
This opportunity uses the NIH R21 mechanism, which is designed for exploratory and developmental projects. R21 awards typically support proof-of-concept studies, feasibility demonstrations, and early validation of novel methods that could later be expanded into larger research programs. The FOA sits within the oral health research space, listed under CFDA 93.121 (Oral Diseases and Disorders Research), and it is categorized as a health-related discretionary grant program. Cost sharing or matching is not required, which means applicants are not expected to provide non-federal funds as a condition of receiving an award.
Funding levels for the overall announcement were estimated at 3,000,000 total. The stated award ceiling is 200,000, indicating that individual awards were capped at that amount under this announcement. The posting and creation dates were August 1, 2011, with an original and current closing date of November 29, 2011, and an archive date of December 30, 2011. In other words, this was a time-limited solicitation with a single application window in late 2011, and it has since been archived, though the content remains useful as a reference for what NIH sought to fund in this area.
Eligibility was intentionally expansive. In addition to typical research institutions, the FOA allowed applications from a wide mix of organizations, including public and state controlled institutions of higher education and private universities, nonprofits with or without 501(c)(3) status (other than institutions of higher education), small businesses, and for-profit organizations that are not small businesses. It also welcomed government entities at multiple levels, such as state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public housing authorities and Indian housing authorities. Tribal participation was supported through eligibility for federally recognized Native American tribal governments and tribal organizations that are not federally recognized, and the FOA explicitly included Tribally Controlled Colleges and Universities (TCCUs).
The eligibility section further clarified that a range of mission-driven and capacity-building institution types could apply, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. Regional organizations were also eligible. Importantly, the FOA permitted participation by non-domestic (non-U.S.) entities and foreign organizations, and it allowed foreign components of U.S. organizations. That signals an openness to international expertise, collaborations, and specialized capabilities that may be essential for cutting-edge tissue engineering, regenerative medicine, biomaterials, stem cell approaches, or other advanced strategies relevant to functional salivary restoration.
For applicants and interested parties who need the official, full program language, the FOA pointed to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-12-005.html. The contact information provided was the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV) for issues accessing or linking to the announcement.
Functional Restoration of Salivary Glands (R21) (RFA-DE-12-005) - FAQs
What is the Functional Restoration of Salivary Glands (R21) funding opportunity?
It is a National Institutes of Health (NIH) funding opportunity announcement (FOA) focused on jump-starting early, exploratory research to restore salivary gland function after damage. It emphasizes early-stage, high-risk, high-impact ideas where preliminary evidence may be limited but the potential payoff is large.
What is the FOA number and title?
The FOA is titled "Functional Restoration of Salivary Glands (R21)" and is identified as RFA-DE-12-005.
What type of grant mechanism does this FOA use?
This opportunity uses the NIH R21 mechanism, which is intended for exploratory and developmental research projects.
What kinds of projects are a good fit for an NIH R21 in this announcement?
The FOA targets proof-of-concept studies, feasibility demonstrations, and early validation of novel methods. The intent is to support work that could later be expanded into larger research programs, rather than incremental extensions of established approaches.
What is the main scientific goal of the FOA?
The overarching goal is to improve or re-establish saliva production and functional salivary gland activity after the glands have been damaged.
What approaches to restoring salivary function are included in the scientific scope?
The scope is broad and includes multiple pathways to the same goal, such as repairing injured glands, regenerating a patient's own salivary tissue, or replacing lost function through a bioengineered salivary gland.
Is this FOA looking for incremental research or more exploratory work?
The FOA emphasizes breaking new ground or extending earlier discoveries into new directions. It is positioned for high-risk, high-impact concepts rather than incremental work.
What research area or program classification does this fall under?
It is within oral health research and is listed under CFDA 93.121 (Oral Diseases and Disorders Research). It is categorized as a health-related discretionary grant program.
Is cost sharing or matching required?
No. Cost sharing or matching is not required, meaning applicants are not expected to provide non-federal funds as a condition of receiving an award.
How much total funding was estimated for this announcement?
The overall estimated funding level for the announcement was 3,000,000 total.
What was the maximum award amount per project under this FOA?
The stated award ceiling was 200,000, meaning individual awards were capped at 200,000 under this announcement.
When was this FOA posted, and what were the key dates?
The posting and creation dates were August 1, 2011. The original and current closing date was November 29, 2011. The archive date was December 30, 2011.
Is this funding opportunity still open?
No. It had a single application window in late 2011 and has since been archived (archive date: December 30, 2011). The content may still be useful as a reference for NIH priorities in this area at that time.
What types of organizations were eligible to apply?
Eligibility was intentionally expansive and included public and state controlled institutions of higher education, private universities, nonprofits with or without 501(c)(3) status (other than institutions of higher education), small businesses, and for-profit organizations that are not small businesses.
Were government entities eligible to apply?
Yes. Eligible applicants included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities and Indian housing authorities.
Were tribal governments and tribal organizations eligible?
Yes. The FOA supported tribal participation by including eligibility for federally recognized Native American tribal governments and tribal organizations that are not federally recognized. It also explicitly included Tribally Controlled Colleges and Universities (TCCUs).
Were minority-serving and mission-driven institutions eligible?
Yes. The eligibility section included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Were regional organizations eligible?
Yes. Regional organizations were listed as eligible applicants.
Could non-U.S. (foreign) organizations apply?
Yes. The FOA permitted participation by non-domestic (non-U.S.) entities and foreign organizations, and it allowed foreign components of U.S. organizations.
Where can applicants find the official FOA text?
The FOA directed readers to the NIH Grants Guide page: http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-12-005.html.
Who should be contacted for help accessing or linking to the announcement?
The contact listed for issues accessing or linking to the announcement was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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