Opportunity Information: Apply for PA 12 208
Apply for PA 12 208
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Functions of Skeletal Muscle beyond Contraction (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Aug 6, 2012 and posted on Jun 22, 2012.
- Applicants must submit their applications by Sep 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Special district governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Independent school districts Small businesses State governments Private institutions of higher education City or township governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institutes of Health (NIH), through the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), offered the grant opportunity "Functions of Skeletal Muscle beyond Contraction (R01)" under Funding Opportunity Number PA 12-208. It is an R01 discretionary research grant focused on pushing skeletal muscle research past the traditional emphasis on contraction and locomotion. The central idea is that skeletal muscle is not just a mechanical tissue for movement, but also an active regulator of whole-body physiology, communicating with other organs and influencing health and disease in ways that are still not fully understood. NIAMS encouraged innovative, hypothesis-driven projects that explore the broader biological roles of muscle and the mechanisms that control those roles.
A major emphasis of the announcement is on the "non-contractile" functions of skeletal muscle, especially its endocrine and paracrine signaling. This includes the study of myokines and other muscle-derived factors that act locally within muscle tissue or travel through circulation to influence distant organs. The opportunity also highlights interest in resting muscle thermogenesis, meaning heat production and energy expenditure in muscle even when it is not actively contracting. Another featured area is muscle as a sensor and responder to biomechanical stimuli, which can include how muscle cells detect stretch, load, stiffness, and other physical cues and convert them into biochemical signals that affect growth, remodeling, inflammation, metabolism, and systemic physiology. In addition, the announcement points to muscle as a reservoir for amino acids and as a key tissue in regulating systemic metabolism, reinforcing the idea that muscle function is tightly intertwined with nutrient handling, insulin sensitivity, and energy balance.
The public health motivation is that better understanding these broader muscle functions could open up new prevention or treatment strategies for common and costly conditions. The announcement specifically links this science to diseases and syndromes such as cachexia (wasting associated with chronic illness), obesity, diabetes, and sarcopenia (age-related loss of muscle mass and function). The underlying message is that muscle-driven signaling and metabolic control may be leveraged therapeutically, either by preserving muscle health, modifying muscle-to-organ communication, or targeting pathways that connect muscle biology to whole-body outcomes.
Administratively, this opportunity falls under the NIH grant mechanism category "Grant" and the activity category "Health." It lists multiple CFDA numbers reflecting relevance across NIH areas, including 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research), 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), and 93.866 (Aging Research). There was no cost sharing or matching requirement. The opportunity was posted June 22, 2012, created August 6, 2012, and had an original and current closing date of September 7, 2015, after which it was archived on October 8, 2015. In practical terms, that means the specific announcement is no longer open for applications, though similar topics may appear in newer NIH funding announcements.
Eligibility was broad and included many types of organizations and institutions. Eligible applicants listed in the source data include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (including those outside universities), for-profit organizations (other than small businesses), small businesses, and a range of governmental entities (state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities). The announcement also explicitly included Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized tribal governments). Additional eligible applicants included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). This wide eligibility signals NIH interest in attracting diverse teams and perspectives, including international participation where appropriate.
For reference, NIH provided an additional information link to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PA-12-208.html (as listed in the source), and included contact guidance directing technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Functions of Skeletal Muscle beyond Contraction (R01)".
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA 12-208.
Which NIH institute offered this opportunity?
The opportunity was offered by the National Institutes of Health (NIH) through the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
What type of grant mechanism is this?
This is an NIH R01 research project grant opportunity (a discretionary research grant). The listing identifies the mechanism category as Grant and the activity category as Health.
What is the main scientific purpose of the opportunity?
The purpose is to push skeletal muscle research beyond the traditional focus on contraction and locomotion, emphasizing that skeletal muscle also acts as an active regulator of whole-body physiology through communication with other organs and broader systemic effects.
What does “beyond contraction” mean in this announcement?
In this context, it means studying skeletal muscle as more than a mechanical tissue for movement. The announcement encourages work on broader biological roles of muscle and the mechanisms that control those roles, including how muscle influences health and disease through signaling, metabolism, and responses to physical cues.
What major research theme is highlighted?
A major theme is the “non-contractile” functions of skeletal muscle, especially endocrine and paracrine signaling and other ways muscle can affect local tissue and distant organs.
Does the opportunity specifically mention endocrine or paracrine signaling from muscle?
Yes. It explicitly emphasizes endocrine and paracrine signaling, including the study of myokines and other muscle-derived factors that act within muscle or circulate to influence distant organs.
What are myokines in the context of this opportunity?
Myokines are muscle-derived factors highlighted in the announcement as signaling molecules that can act locally (within muscle tissue) or travel through circulation to influence other organs.
Is resting muscle thermogenesis included as an area of interest?
Yes. The opportunity highlights resting muscle thermogenesis, described as heat production and energy expenditure in muscle even when it is not actively contracting.
What does the announcement say about muscle sensing and biomechanics?
It highlights skeletal muscle as a sensor and responder to biomechanical stimuli, including how muscle cells detect stretch, load, stiffness, and other physical cues and convert them into biochemical signals. These signals can affect growth, remodeling, inflammation, metabolism, and systemic physiology.
Does the announcement address muscle’s role in systemic metabolism?
Yes. It points to muscle as a reservoir for amino acids and as a key tissue in regulating systemic metabolism, emphasizing links to nutrient handling, insulin sensitivity, and energy balance.
What kinds of projects were encouraged?
NIAMS encouraged innovative, hypothesis-driven projects that explore broader biological roles of skeletal muscle and the mechanisms that control those roles.
What public health conditions are mentioned as motivation for this research?
The announcement links the science to prevention or treatment strategies for conditions including cachexia, obesity, diabetes, and sarcopenia.
How does the opportunity relate to cachexia, obesity, diabetes, and sarcopenia?
The announcement suggests that improved understanding of muscle-driven signaling and metabolic control could lead to new strategies to prevent or treat these conditions, for example by preserving muscle health, modifying muscle-to-organ communication, or targeting pathways connecting muscle biology to whole-body outcomes.
Is cost sharing or matching required?
No. The opportunity states there was no cost sharing or matching requirement.
Is this funding opportunity still open for applications?
No. The original and current closing date was September 7, 2015, and the announcement was archived on October 8, 2015. That means this specific announcement is no longer open for applications.
When was the opportunity posted and created?
It was posted on June 22, 2012 and created on August 6, 2012.
What are the CFDA numbers associated with this opportunity?
The opportunity lists multiple CFDA numbers: 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research), 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), and 93.866 (Aging Research).
Who was eligible to apply?
Eligibility was broad and included many organization types, including higher education institutions, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and a wide range of governmental entities. It also included tribal governments and tribal organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and non-U.S. entities (foreign organizations).
Are public or state-controlled institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education were listed as eligible applicants.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education were listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status were both listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations were listed as eligible, including those other than small businesses. Small businesses were also separately listed as eligible.
Are small businesses eligible?
Yes. Small businesses were explicitly listed as eligible applicants.
What government entities were listed as eligible applicants?
The listing includes state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are Native American tribal governments or tribal organizations eligible?
Yes. The announcement explicitly included Native American tribal governments (federally recognized) and tribal organizations, including those other than federally recognized tribal governments.
Are minority-serving institutions mentioned as eligible?
Yes. The eligible applicant types listed include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were included in the listed eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were included in the listed eligible applicants.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility list explicitly included non-U.S. entities (foreign organizations).
Where can the full announcement be found?
NIH provided the link to the full announcement here: http://grants.nih.gov/grants/guide/pa-files/PA-12-208.html.
Who should be contacted for technical access or linking issues related to the announcement page?
The contact guidance directs technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Does the archived status mean NIH no longer funds this topic?
The information provided indicates only that this specific announcement is no longer open. It also notes that similar topics may appear in newer NIH funding announcements, but no specific current opportunity is provided in the source information.
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