Opportunity Information: Apply for W81XWH 09 LCRP LCBRNA
Apply for W81XWH 09 LCRP LCBRNA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "FY09 DOD Lung Cancer Biospecimen Resource Network Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Sep 11, 2009 and posted on Sep 11, 2009.
- Applicants must submit their applications by Jan 6, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,800,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The FY09 DOD Lung Cancer Biospecimen Resource Network (LCBRN) Award is a Department of Defense funding opportunity focused on building shared infrastructure for lung cancer research rather than funding a single stand-alone study. The goal is to create a coordinated, multi-institutional biospecimen resource that can reliably collect, process, annotate, store, and distribute high-quality human lung cancer specimens and the associated data needed to support a range of research efforts. By standardizing how specimens and information are handled across participating sites, the program aims to make biospecimens more useful, comparable, and broadly accessible for investigators working on lung cancer detection, biology, and treatment response.
The network structure is a central requirement of the award. Applicants must propose a collaborative network made up of a Coordinating Center plus at least two additional Biospecimen Resource Sites, and the entire network must be submitted as a single joint application. The Coordinating Center also serves as a specimen resource site, but it is expected to contribute capabilities or assets that may not exist at every participating site, such as specialized processing methods, advanced technology platforms, harmonized data systems, or network-wide quality control and distribution functions. In practice, the award is designed to push institutions to operate as one integrated resource rather than as separate biobanks.
The scope of biospecimens envisioned is intentionally broad to match the needs of modern lung cancer research, including studies that require both invasive and minimally invasive sample types. Examples listed include tumor tissue and matched non-tumor lung material (like uninvolved lung parenchyma or airway epithelium), as well as specimens such as blood, sputum, lung exhalant-related samples, hair, toenails, and bronchoscopic brushings and biopsies. The emphasis is on building a resource capable of supporting diverse downstream analyses and study designs, including research that depends on paired samples, longitudinal sampling, or comparison across lung cancer subtypes.
Beyond physical sample collection and storage, the award requires strong data capabilities. The proposed LCBRN must be able to collect, store, and manage the data derived from the biospecimens, which typically includes clinical and pathological annotation, processing metadata, and results from molecular or other assays. Applicants are expected to demonstrate the ability to generate or prepare key analytes, including derivatization of DNA, RNA, and proteins, and to employ both standard and state-of-the-art processing technologies. Specific examples mentioned include laser capture microdissection and tissue microarrays, signaling that the program values advanced methods that increase specimen utility, enable precise cellular sampling, and support high-throughput research.
To ensure the network directly supports priority research needs, the biospecimens and associated data must be suitable for at least two or more program Areas of Emphasis. These areas include improving detection of early-stage lung cancer using non-invasive or minimally invasive approaches; developing or improving screening and early detection tools (including imaging such as CT or X-ray, as well as biomarkers and genetics/genomics/proteomics and risk-factor assessment); understanding molecular mechanisms that drive clinically significant disease; clarifying mechanisms behind different lung cancer types; developing innovative prevention and early treatment strategies; identifying predictive and prognostic markers to distinguish responders from non-responders; and understanding how tumors develop acquired resistance to treatment. In other words, the biorepository is expected to be built with research translation in mind, enabling work from early detection through treatment outcomes.
Administratively, this opportunity was offered as a cooperative agreement (meaning the government may have substantial involvement in project oversight and coordination), under the Military Medical Research and Development CFDA listing (12.420). The opportunity expected to make a single award, with an estimated total funding level of $3.8 million and no cost-sharing requirement. Eligibility was described as unrestricted, subject to any additional clarifications in the full announcement. The opportunity was posted September 11, 2009, with an application closing date of January 6, 2010, and it was administered by the Department of the Army through USAMRAA (U.S. Army Medical Research Acquisition Activity). For applicants needing support, the announcement provided contacts for program announcement access and electronic submission help through CDMRP support channels.
FY09 DOD Lung Cancer Biospecimen Resource Network (LCBRN) Award FAQs
What is the FY09 DOD Lung Cancer Biospecimen Resource Network (LCBRN) Award?
The FY09 DOD LCBRN Award is a Department of Defense funding opportunity focused on building shared infrastructure for lung cancer research. Rather than funding a single stand-alone research study, it supports the creation of a coordinated, multi-institutional biospecimen resource that can collect, process, annotate, store, and distribute high-quality human lung cancer specimens and the associated data.
What is the main goal of this award?
The goal is to create a standardized, coordinated biospecimen network so that specimens and data are handled consistently across participating sites. This is intended to make biospecimens more useful, comparable across institutions, and broadly accessible to investigators studying lung cancer detection, biology, treatment response, and related topics.
Is this funding meant to support a single research project?
No. The award is designed to build a shared resource (a networked biospecimen infrastructure) that can support many different lung cancer research efforts, rather than a single stand-alone study conducted by one institution.
What kind of award mechanism is being used?
This opportunity was offered as a cooperative agreement. This typically means the government may have substantial involvement in project oversight and coordination compared to standard grants.
Who administered this opportunity?
The opportunity was administered by the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the CFDA listing for this opportunity?
The award was listed under Military Medical Research and Development CFDA 12.420.
How many awards were expected to be made?
The announcement expected to make a single award.
What was the estimated total funding level?
The estimated total funding level was $3.8 million.
Was cost sharing required?
No cost-sharing requirement was listed for this opportunity.
Who was eligible to apply?
Eligibility was described as unrestricted, subject to any additional clarifications in the full announcement.
When was the opportunity posted and when was the application due?
The opportunity was posted on September 11, 2009. The application closing date was January 6, 2010.
What is the required network structure for an application?
Applicants were required to propose a collaborative network consisting of a Coordinating Center plus at least two additional Biospecimen Resource Sites. The entire network had to be submitted as a single joint application.
Does the Coordinating Center also function as a biospecimen site?
Yes. The Coordinating Center also serves as a specimen resource site.
What special role is the Coordinating Center expected to play?
The Coordinating Center is expected to provide capabilities or assets that may not exist at every participating site. Examples include specialized processing methods, advanced technology platforms, harmonized data systems, and network-wide quality control and distribution functions.
Why does the program emphasize a network approach?
The award is designed to push institutions to operate as one integrated resource rather than as separate biobanks. Standardization across sites is a core feature to improve consistency, comparability, and broad usability of specimens and data.
What types of biospecimens are envisioned for the resource?
The scope is intentionally broad and includes both invasive and minimally invasive sample types. Examples listed include tumor tissue and matched non-tumor lung material (such as uninvolved lung parenchyma or airway epithelium), as well as blood, sputum, lung exhalant-related samples, hair, toenails, and bronchoscopic brushings and biopsies.
Does the program emphasize paired or longitudinal samples?
Yes. The description highlights supporting diverse study designs, including research that depends on paired samples, longitudinal sampling, and comparisons across lung cancer subtypes.
Besides collecting and storing specimens, what else must the network provide?
The LCBRN must have strong data capabilities, including the ability to collect, store, and manage data derived from biospecimens. This typically includes clinical and pathological annotation, processing metadata, and results from molecular or other assays.
What kinds of processing and analyte preparation capabilities are expected?
Applicants were expected to demonstrate the ability to generate or prepare key analytes, including derivatization of DNA, RNA, and proteins, and to employ both standard and state-of-the-art processing technologies.
Are advanced technologies specifically mentioned?
Yes. Specific examples include laser capture microdissection and tissue microarrays, signaling the value placed on advanced methods that increase specimen utility, enable precise cellular sampling, and support high-throughput research.
What are the program Areas of Emphasis the resource must support?
The biospecimens and associated data must be suitable for at least two or more Areas of Emphasis, including: improving detection of early-stage lung cancer using non-invasive or minimally invasive approaches; developing or improving screening and early detection tools (including imaging such as CT or X-ray, biomarkers, genetics/genomics/proteomics, and risk-factor assessment); understanding molecular mechanisms driving clinically significant disease; clarifying mechanisms behind different lung cancer types; developing innovative prevention and early treatment strategies; identifying predictive and prognostic markers to distinguish responders from non-responders; and understanding how tumors develop acquired resistance to treatment.
Does the award emphasize translational relevance?
Yes. The resource is expected to be built with research translation in mind, enabling studies spanning early detection through treatment outcomes, including response and resistance.
What kind of standardization is expected across sites?
The opportunity emphasizes standardizing how specimens and information are collected, processed, annotated, stored, and distributed across participating sites to improve reliability and comparability.
Where could applicants get help with the announcement and electronic submission?
The announcement indicated that contacts were provided for program announcement access and electronic submission help through CDMRP support channels.
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