Opportunity Information: Apply for W81XWH 11 MRPRA TRA
Apply for W81XWH 11 MRPRA TRA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "FY11 Militarily Relevant Peer Reviewed Alzheimers Disease Research Program (MRPRA) Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 6, 2012 and posted on Mar 16, 2012.
- Applicants must submit their applications by Apr 16, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The FY11 Militarily Relevant Peer Reviewed Alzheimers Disease Research Program (MRPRA) Translational Research Award is a U.S. Department of Defense funding opportunity focused on the real-world, military-relevant intersection between traumatic brain injury (TBI) and Alzheimers disease (AD). The program is sponsored under the Office of the Assistant Secretary of Defense for Health Affairs, through the Defense Health Program Medical Research and Development Office. While the Telemedicine and Advanced Technology Research Center (TATRC) runs the application intake and process, the U.S. Army Medical Research Acquisition Activity (USAMRAA) publishes the program announcement and is responsible for negotiating and issuing the resulting awards.
At its core, the MRPRA mission is to build an integrated research effort that clarifies how TBI may be linked to later Alzheimers disease and related neurodegenerative outcomes, with the larger goal of reducing the long-term burden on affected service members, veterans, and their families. The announcement emphasizes that moderate to severe TBI in military populations can increase risk for serious, lasting neurological and behavioral problems, including Alzheimers-like dementia, memory loss, depression, aggression, and symptoms that overlap with other neurological diseases. It also highlights that even mild TBI may be associated with adverse long-term consequences, which makes early detection and better characterization of neurological change a pressing need for both military medicine and public health.
The funding priorities are framed around two main objectives. First, the program seeks translational research that accelerates the development of research tools and clinically meaningful outcome measures that can help detect, identify, and diagnose neurological changes consistent with TBI-associated Alzheimers disease. In practical terms, this is aimed at moving beyond basic observations toward usable methods that clinicians and researchers can rely on to recognize disease-related changes earlier, track progression, and distinguish TBI-related neurodegeneration from other conditions. Second, the program places equal importance on technology development intended to directly help people experiencing neurological impairment symptoms related to either TBI or AD. This includes technologies or approaches designed to maintain or improve quality of life, meaning the work is not limited to diagnostics and biomarkers but also includes tangible, patient-facing solutions that can support daily function and well-being.
The announcement describes the expected outputs as research resources that can be used by professionals and practitioners across health, medical science, and related fields, aligned with the program mission. Although the program is explicitly built around military relevance and is intended to benefit the military community, it is also positioned as serving a broader public purpose, with spillover benefits for civilian patients and healthcare systems dealing with TBI, dementia, and neurodegenerative disease.
From an administrative and funding standpoint, this opportunity (Funding Opportunity Number W81XWH-11-MRPRA-TRA) falls under the CFDA 12.420 (Military Medical Research and Development) and supports projects through either grants or cooperative agreements. It anticipated making about 8 awards, with an estimated total program funding of $4,000,000 and an award ceiling of $500,000 per project. Cost sharing or matching was not required. Eligibility was listed as unrestricted, meaning proposals could generally come from any type of entity as long as they met any additional eligibility clarifications in the full text. The opportunity was posted March 16, 2012, with an application closing date of April 16, 2012, and it was administered for awards expected in calendar year 2012. For access issues related to the full announcement, the listed point of contact was Mary Rico (Grants Officer) for electronic access problems.
FY11 MRPRA Translational Research Award (W81XWH-11-MRPRA-TRA) - FAQs
What is the FY11 MRPRA Translational Research Award?
The FY11 Militarily Relevant Peer Reviewed Alzheimers Disease Research Program (MRPRA) Translational Research Award is a U.S. Department of Defense funding opportunity focused on translational work at the military-relevant intersection of traumatic brain injury (TBI) and Alzheimers disease (AD), including related neurodegenerative outcomes.
Which government organization sponsors this program?
The program is sponsored under the Office of the Assistant Secretary of Defense for Health Affairs, through the Defense Health Program Medical Research and Development Office.
Who runs the application intake and process?
The Telemedicine and Advanced Technology Research Center (TATRC) runs the application intake and process.
Who publishes the announcement and issues the awards?
The U.S. Army Medical Research Acquisition Activity (USAMRAA) publishes the program announcement and is responsible for negotiating and issuing the resulting awards.
What is the mission of the MRPRA program?
The mission is to build an integrated research effort that clarifies how TBI may be linked to later Alzheimers disease and related neurodegenerative outcomes, with the larger goal of reducing the long-term burden on affected service members, veterans, and their families.
Why is this opportunity considered military-relevant?
The announcement emphasizes that TBI in military populations (including moderate to severe TBI, and potentially even mild TBI) can be associated with serious long-term neurological and behavioral problems. The program is designed to address the needs of military medicine and the military community, while also providing broader public health benefits.
What long-term outcomes does the announcement associate with TBI?
The opportunity notes that moderate to severe TBI can increase risk for lasting neurological and behavioral problems, including Alzheimers-like dementia, memory loss, depression, aggression, and symptoms overlapping with other neurological diseases. It also highlights that even mild TBI may be associated with adverse long-term consequences.
What are the main funding objectives?
The funding priorities are framed around two main objectives:
- Translational research that accelerates development of research tools and clinically meaningful outcome measures to help detect, identify, and diagnose neurological changes consistent with TBI-associated Alzheimers disease.
- Technology development intended to directly help people experiencing neurological impairment symptoms related to either TBI or AD, including solutions aimed at maintaining or improving quality of life.
What does "translational research" mean in this announcement?
Based on the announcement, translational research is aimed at moving beyond basic observations toward usable tools, methods, and clinically meaningful outcome measures that clinicians and researchers can rely on to recognize disease-related changes earlier, track progression, and distinguish TBI-related neurodegeneration from other conditions.
Are projects limited to diagnostics and biomarkers?
No. The announcement places equal importance on technology development intended to directly help people with neurological impairment symptoms related to TBI or AD, including patient-facing solutions that support daily function and well-being.
What kinds of outputs are expected from funded projects?
The announcement describes expected outputs as research resources that can be used by professionals and practitioners across health, medical science, and related fields, aligned with the program mission.
Is the program intended to benefit only military populations?
While the program is explicitly built around military relevance and intended to benefit the military community, it is also positioned as serving a broader public purpose, with spillover benefits for civilian patients and healthcare systems dealing with TBI, dementia, and neurodegenerative disease.
What is the Funding Opportunity Number (FON) for this award?
The Funding Opportunity Number is W81XWH-11-MRPRA-TRA.
What is the CFDA number associated with this opportunity?
The opportunity falls under CFDA 12.420 (Military Medical Research and Development).
What funding mechanisms are used for this opportunity?
The opportunity supports projects through either grants or cooperative agreements.
How many awards were anticipated?
The program anticipated making about 8 awards.
What was the estimated total program funding?
The estimated total program funding was $4,000,000.
What was the maximum award amount per project?
The award ceiling was $500,000 per project.
Was cost sharing or matching required?
No. Cost sharing or matching was not required.
Who was eligible to apply?
Eligibility was listed as unrestricted, meaning proposals could generally come from any type of entity, subject to any additional eligibility clarifications in the full announcement text.
When was the opportunity posted?
The opportunity was posted on March 16, 2012.
What was the application deadline?
The application closing date was April 16, 2012.
When were awards expected to be made?
The opportunity was administered for awards expected in calendar year 2012.
Who should be contacted for electronic access problems related to the full announcement?
For electronic access issues related to the full announcement, the listed point of contact was Mary Rico (Grants Officer).
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