Opportunity Information: Apply for W81XWH 15 PRCRP TTSA
Apply for W81XWH 15 PRCRP TTSA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "FY15 Peer Reviewed Cancer Translational Team Science Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Apr 24, 2015 and posted on Apr 24, 2015.
- Applicants must submit their applications by Sep 29, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $21,120,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 11 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The FY15 Peer Reviewed Cancer Research Program (PRCRP) Translational Team Science Award (TTSA) is a U.S. Army (USAMRAA) funding opportunity created to push promising cancer research findings closer to real clinical use. It is specifically designed to support translational, correlative studies that are tied to an existing or already completed clinical trial, with the expectation that the results could inform a practical clinical application or justify the design of the next phase clinical trial. In other words, the program is not paying to run a clinical trial itself; it is paying for the translational science that mines clinical trial-linked samples, data, and outcomes to answer the kinds of questions that determine what should be tested next in patients and how.
The core idea behind this award is leverage: applicants are expected to use information and materials generated through prior clinical trials to close important knowledge gaps left by the trial outcomes. The proposed work can include collecting additional tissues or biopsies when appropriate, or using existing specimen resources that came from the clinical trial setting. The scientific emphasis is on studies that connect biology to real patient outcomes in a way that moves beyond purely descriptive findings and instead points to actionable next steps. The announcement highlights several areas of particular interest, including research on prognosis and treatment differences based on primary nodal status and/or the presence of metastatic disease, studies of cancer precursor lesions and how they relate to prevention and eventual outcomes, investigations into tumor heterogeneity (genetic, epigenetic, or immunological) and how it interacts with the tumor microenvironment, and research centered on patient-reported outcomes and quality of life impacts associated with treatment.
The TTSA allows both preclinical and human-focused translational work, including studies in animal models, human subjects, and research using human anatomical substances. If an appropriate preclinical model is needed to interpret or extend findings from a clinical trial-linked dataset, developing or using those models can be part of the project. At the same time, the award draws a clear boundary around what it is not meant to fund: it is not intended for broad high-throughput efforts such as large screening campaigns or sequencing-heavy projects as the primary thrust. Just as importantly, funding for conducting the associated clinical trial itself is explicitly not allowed; the supported work must be correlative or translational and anchored to an already existing or completed trial.
A defining feature of this opportunity is its required team structure. Rather than a single PI-led project with minor collaborators, the TTSA requires a true multi-PI partnership where investigators jointly design one integrated study and contribute at comparable intellectual levels. The team must include at least three and no more than five Principal Investigators, spanning at least two institutions, and the overall study must fall within one of the required FY15 PRCRP topic areas. Each PI is treated as a PI in full: each submits a separate application package (even if housed at the same organization) and, if the project is selected, each receives an individual award. One PI serves as the Initiating PI and carries most of the administrative coordination for submission, while the others are Partnering PIs with their own submission requirements; however, the intent is that all PIs materially shape the science and execution plan.
The collaboration requirements also include a workforce and mission-related component. The team must include at least one early career investigator and/or one military/VA investigator as an equal partner, contributing real intellectual investment and research effort. Early career is defined as within 10 years of completing a terminal degree (doctorate or medical degree), not counting time in medical residency or periods of family medical leave. A military/VA investigator is defined broadly to include active duty, active reserve, and related DoD-connected statuses, and the announcement emphasizes that this person should not be added merely to gain access to military or VA populations; they must play a substantial scientific role. Multidisciplinary projects are encouraged, reflecting the program's goal of accelerating progress by combining complementary expertise that would not achieve the same impact if pursued as separate, independent projects.
Because the award is built around multi-institution coordination, the application is expected to spell out how the partnership will actually function. Plans should clearly address how the investigators and organizations will communicate, coordinate research progress and results, and transfer data. In addition, the application must include an intellectual property plan aimed at preventing institutional barriers from undermining cooperation. This requirement is meant to anticipate and resolve potential intellectual and material property issues early so the team can share samples, data, methods, and insights at the pace needed for translational work.
From a funding and administrative standpoint, this opportunity (Funding Opportunity Number W81XWH-15-PRCRP-TTSA) was offered as a discretionary program using cooperative agreements and grants under CFDA 12.420 (Military Medical Research and Development). The agency expected to make about 11 awards, with an estimated total funding level of $21,120,000, and there was no cost sharing or matching requirement. Eligibility was listed as unrestricted, meaning any entity type could apply subject to any clarifications in the full announcement. The opportunity was posted April 24, 2015, with a closing date of September 29, 2015, and archived October 29, 2015. For assistance, the announcement directed applicants to the CDMRP Help Desk (help@eBRAP.org, 301-682-5507).
FY15 PRCRP Translational Team Science Award (TTSA) - FAQs
What is the FY15 PRCRP Translational Team Science Award (TTSA)?
The FY15 Peer Reviewed Cancer Research Program (PRCRP) Translational Team Science Award (TTSA) is a U.S. Army (USAMRAA) funding opportunity intended to move promising cancer research findings closer to real clinical use. It supports translational, correlative studies that are tied to an existing or already completed clinical trial, with the expectation that results can inform a practical clinical application or justify the design of a next-phase clinical trial.
What is the main purpose of this award?
The main purpose is to leverage data, outcomes, and materials generated through prior clinical trials to close important knowledge gaps that remain after a trial is completed. The emphasis is on studies that connect biology to real patient outcomes in a way that points to actionable next steps for patient testing and treatment strategy.
Does TTSA fund the clinical trial itself?
No. Funding to conduct the associated clinical trial is explicitly not allowed. The supported work must be correlative or translational and anchored to an already existing or completed clinical trial.
What types of studies are appropriate under this award?
Appropriate studies are translational and correlative projects linked to clinical trials, including research that mines clinical trial-linked samples, data, and outcomes to determine what should be tested next in patients and how. Projects can also include collecting additional tissues or biopsies when appropriate, or using existing specimen resources originating from the clinical trial setting.
Can the project include both preclinical and human-focused translational work?
Yes. The TTSA allows preclinical and human-focused translational work, including studies in animal models, human subjects, and research using human anatomical substances.
Are animal models allowed or required?
Animal models are allowed. If an appropriate preclinical model is needed to interpret or extend findings from a clinical trial-linked dataset, developing or using those models can be part of the project.
What scientific areas are highlighted as being of particular interest?
The announcement highlights several areas of particular interest, including: prognosis and treatment differences based on primary nodal status and/or the presence of metastatic disease; studies of cancer precursor lesions and how they relate to prevention and eventual outcomes; investigations into tumor heterogeneity (genetic, epigenetic, or immunological) and interactions with the tumor microenvironment; and research centered on patient-reported outcomes and quality of life impacts associated with treatment.
What does "translational, correlative studies tied to a clinical trial" mean in practice?
It means the study is anchored to an existing or completed clinical trial and uses trial-derived samples, datasets, and outcomes to answer questions that clarify biological mechanisms and their relationship to patient outcomes, with an eye toward practical clinical application or the design rationale for the next phase clinical trial.
Are high-throughput screening or sequencing-heavy projects allowed?
The award is not intended for broad high-throughput efforts (such as large screening campaigns) or sequencing-heavy projects as the primary thrust of the proposal.
How many Principal Investigators (PIs) are required?
The TTSA requires a true multi-PI partnership with at least three and no more than five Principal Investigators.
Do the PIs have to come from more than one institution?
Yes. The PI team must span at least two institutions.
Is this a single-PI award with collaborators?
No. This opportunity is structured around a multi-PI team where investigators jointly design one integrated study and contribute at comparable intellectual levels, rather than a single PI-led project with minor collaborators.
What is the difference between the Initiating PI and Partnering PIs?
One PI serves as the Initiating PI and carries most of the administrative coordination for submission. The others are Partnering PIs with their own submission requirements. The scientific intent is that all PIs materially shape the science and execution plan as equal partners.
Does each PI submit an application, or is there one combined application?
Each PI submits a separate application package (even if housed at the same organization). If selected, each PI receives an individual award.
Are there required team member categories, such as early career or military/VA investigators?
Yes. The team must include at least one early career investigator and/or one military/VA investigator as an equal partner who contributes real intellectual investment and research effort.
How is an early career investigator defined for this opportunity?
Early career is defined as within 10 years of completing a terminal degree (doctorate or medical degree), not counting time in medical residency or periods of family medical leave.
How is a military/VA investigator defined for this opportunity?
A military/VA investigator is defined broadly to include active duty, active reserve, and related DoD-connected statuses.
Can a military/VA investigator be included mainly to access military or VA populations?
No. The announcement emphasizes that a military/VA investigator should not be added merely to gain access to military or VA populations; they must play a substantial scientific role.
Does the program encourage multidisciplinary collaboration?
Yes. Multidisciplinary projects are encouraged to accelerate progress by combining complementary expertise that would not achieve the same impact if pursued as separate, independent projects.
Are there required research topic areas?
Yes. The overall study must fall within one of the required FY15 PRCRP topic areas.
What partnership and coordination details are expected in the application?
Because the award is built around multi-institution coordination, the application is expected to explain how the partnership will function. Plans should address communication, coordination of research progress and results, and data transfer among investigators and organizations.
Is an intellectual property (IP) plan required?
Yes. The application must include an intellectual property plan aimed at preventing institutional barriers from undermining cooperation. The intent is to anticipate and resolve potential intellectual and material property issues early so the team can share samples, data, methods, and insights efficiently.
What is the Funding Opportunity Number for this award?
The Funding Opportunity Number is W81XWH-15-PRCRP-TTSA.
What CFDA number is associated with this opportunity?
This opportunity was offered under CFDA 12.420 (Military Medical Research and Development).
What funding mechanism was used?
The opportunity was offered as a discretionary program using cooperative agreements and grants.
How many awards were expected, and what was the estimated total funding?
The agency expected to make about 11 awards, with an estimated total funding level of $21,120,000.
Is cost sharing or matching required?
No. There was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was listed as unrestricted, meaning any entity type could apply (subject to any clarifications in the full announcement).
When was the opportunity posted, and what were the close and archive dates?
The opportunity was posted on April 24, 2015. The closing date was September 29, 2015, and it was archived on October 29, 2015.
Where can applicants get help or support for this opportunity?
Applicants were directed to contact the CDMRP Help Desk at help@eBRAP.org or 301-682-5507.
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