Opportunity Information: Apply for PA 15 110
Apply for PA 15 110
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Gene Environment Interplay in Substance Use Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Feb 5, 2015 and posted on Feb 5, 2015.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Special district governments Public housing authorities/Indian housing authorities Small businesses For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education City or township governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Gene Environment Interplay in Substance Use Disorders (R01) funding opportunity (PA-15-110) is an NIH research grant announcement designed to grow and sharpen the science around how genetic factors and environmental experiences work together to shape substance use disorders (SUDs), including alcohol use disorders. The central goal is to move beyond treating "genes" and "environment" as separate contributors and instead fund studies that can explain how they combine over time to influence the start of substance use, escalation to disorder, persistence or relapse, remission, and downstream harms. NIH is emphasizing that SUDs are developmental conditions with strong heritable components, but that heritability does not mean inevitability; environmental contexts and exposures can amplify, buffer, or redirect genetic risk across the lifespan.
The announcement highlights that prior genetic epidemiology and molecular genetics work has already shown SUDs to be highly heritable and to have meaningful genetic substrates. Building on that foundation, the FOA calls for new, genetically informative research approaches that can handle the real-world complexity of SUD trajectories. That includes studying how gene-environment interplay affects developmental pathways, how it relates to comorbid psychiatric or medical conditions, and how it influences outcomes such as adverse consequences, recovery, and cessation. A major priority is improving how SUD phenotypes are defined and measured, since "substance use disorder" can look different across people, substances, ages, and settings. NIH is also signaling interest in work that addresses methodological challenges in the field, which commonly include separating correlation from causation (for example, distinguishing true environmental effects from genetic selection into certain environments), accounting for developmental timing, and dealing with complex, multidimensional exposures.
In practical terms, the research encouraged under this FOA would typically use designs and data sources capable of teasing apart genetic and environmental contributions and their interactions. That can include family-based and twin designs, adoption studies, longitudinal cohort studies, and modern genomics paired with rich environmental measurement. The intent is not only to clarify risk mechanisms, but also to create clearer pathways toward translation: better targets for prevention, more tailored treatment strategies, improved identification of high-risk trajectories, and stronger foundations for gene-finding and molecular follow-up studies. By mapping how specific environments (such as stress, trauma, peer networks, neighborhood conditions, availability of substances, policy contexts, or protective factors) interact with genetic liability, NIH is aiming to support research that can ultimately inform interventions that are timed and tailored to when they will matter most.
Administratively, this is a discretionary NIH grant using the R01 mechanism, which generally supports investigator-initiated, hypothesis-driven research projects of substantial scope. It falls under CFDA 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). The opportunity does not require cost sharing or matching. It was posted February 5, 2015, with an original and current closing date listed as September 7, 2017, and an archive date of October 8, 2017, meaning it is no longer open under those dates but remains useful as a reference for NIH priorities and the type of science the institutes sought to stimulate.
Eligibility is broad and includes many types of domestic institutions and organizations, such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses and other for-profit organizations, and state, local, county, city, township, and special district governments. It also includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and a range of mission-focused institutions (for example, HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities). The eligibility list also explicitly includes certain non-U.S. entities (foreign organizations), U.S. territories or possessions, regional organizations, faith-based or community-based organizations, and eligible federal agencies, reflecting NIH's openness to diverse applicant types capable of carrying out rigorous research in this area.
The full announcement was hosted on the NIH grants site at the link provided in the source material, and NIH listed the Office of Extramural Research (OER) webmaster contacts for technical issues accessing or linking to the FOA.
Frequently Asked Questions (FAQs): Gene Environment Interplay in Substance Use Disorders (R01) - PA-15-110
What is the PA-15-110 funding opportunity about?
PA-15-110, titled "Gene Environment Interplay in Substance Use Disorders (R01)," is an NIH research grant announcement focused on advancing science on how genetic factors and environmental experiences work together over time to shape substance use disorders (SUDs), including alcohol use disorders.
What is the main goal of this FOA?
The main goal is to move beyond treating "genes" and "environment" as separate influences and instead fund studies that explain how they combine across development to affect key SUD outcomes such as initiation of substance use, escalation to disorder, persistence or relapse, remission, and downstream harms.
Why does NIH emphasize gene-environment interplay for SUDs?
NIH notes that SUDs are developmental conditions with strong heritable components, but heritability does not mean outcomes are inevitable. Environmental contexts and exposures can amplify, buffer, or redirect genetic risk across the lifespan.
What kinds of research questions does the announcement encourage?
The FOA encourages research that examines how gene-environment interplay influences developmental pathways of SUDs, how it relates to comorbid psychiatric or medical conditions, and how it shapes outcomes such as adverse consequences, recovery, cessation, relapse, and remission.
Does the FOA prioritize any particular aspect of measurement or phenotyping?
Yes. A major priority is improving how SUD phenotypes are defined and measured, recognizing that "substance use disorder" can present differently across individuals, substances, ages, and settings.
What methodological challenges does NIH highlight in this area?
The announcement signals interest in work that addresses common methodological challenges, including separating correlation from causation (for example, distinguishing true environmental effects from genetic selection into certain environments), accounting for developmental timing, and handling complex, multidimensional environmental exposures.
What kinds of study designs or data sources are considered appropriate for this research?
The FOA describes genetically informative approaches capable of teasing apart genetic and environmental contributions and their interactions. Examples mentioned include family-based and twin designs, adoption studies, longitudinal cohort studies, and modern genomics paired with rich environmental measurement.
What types of environmental factors are relevant under this FOA?
Examples of environments and exposures noted include stress, trauma, peer networks, neighborhood conditions, substance availability, policy contexts, and protective factors. The focus is on how these factors interact with genetic liability and how that interaction changes over time.
What outcomes across the SUD trajectory are of interest?
The FOA highlights the full trajectory: initiation of substance use, escalation to disorder, persistence, relapse, remission, recovery, cessation, and downstream harms or adverse consequences.
How is this FOA intended to support translation to prevention or treatment?
While the FOA is research-focused, NIH expresses an intent to clarify risk mechanisms and create clearer pathways toward translation, including better targets for prevention, more tailored treatment strategies, improved identification of high-risk trajectories, and stronger foundations for gene-finding and molecular follow-up studies.
What grant mechanism is used?
This opportunity uses the NIH R01 mechanism, which generally supports investigator-initiated, hypothesis-driven research projects of substantial scope.
Is this a mandatory funding opportunity with set-aside funds?
The announcement is described as a discretionary NIH grant opportunity using the R01 mechanism. The provided information does not indicate cost sharing requirements or matching.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
Which program areas (CFDA numbers) are associated with this FOA?
The FOA is associated with CFDA 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
When was the FOA posted, and is it still open?
It was posted on February 5, 2015. The original and current closing date listed is September 7, 2017, with an archive date of October 8, 2017. Based on those dates, it is no longer open, but it remains useful as a reference for NIH priorities and the kind of science NIH sought to stimulate.
Who is eligible to apply?
Eligibility is broad and includes many domestic institutions and organizations: public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses and other for-profit organizations, and state/local/county/city/township/special district governments.
Are tribal entities eligible?
Yes. The eligibility list includes tribal governments and tribal organizations, as well as tribally controlled colleges and universities.
Are school districts and housing authorities eligible?
Yes. The eligibility list explicitly includes independent school districts and public housing authorities/Indian housing authorities.
Are certain mission-focused or minority-serving institutions explicitly included?
Yes. The eligibility list includes institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Can non-U.S. organizations apply?
Yes. The eligibility list explicitly includes certain non-U.S. entities (foreign organizations), as well as U.S. territories or possessions and regional organizations.
Are faith-based or community-based organizations eligible?
Yes. The eligibility list includes faith-based or community-based organizations.
Are federal agencies eligible?
Yes. The eligibility list indicates that eligible federal agencies may apply.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website at the link provided in the source material.
Who is listed for technical help accessing or linking to the FOA?
NIH listed Office of Extramural Research (OER) webmaster contacts for technical issues related to accessing or linking to the funding opportunity announcement.
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| Research Answers to NCIs Provocative Questions (R01) Apply for RFA CA 15 008 Funding Number: RFA CA 15 008 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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