Opportunity Information: Apply for PA 15 111
Apply for PA 15 111
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Gene Environment Interplay in Substance Use Disorders (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Feb 5, 2015 and posted on Feb 5, 2015.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education For profit organizations other than small businesses State governments Independent school districts Special district governments County governments Native American tribal governments (Federally recognized) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Gene Environment Interplay in Substance Use Disorders (R03) opportunity (Funding Opportunity Number PA 15 111) is an NIH discretionary grant announcement designed to spur new, smaller-scope research projects that clarify how genetic factors and environmental exposures work together to influence substance and alcohol use disorders (SUDs). The central idea is that SUDs are strongly heritable and develop over time, but genes alone do not explain who initiates use, who progresses to disorder, who develops comorbid conditions, who experiences adverse outcomes, and who recovers or stops using. This FOA emphasizes the need for genetically informative study designs and analytic approaches that can untangle gene-environment interplay across the developmental course of SUDs, including transitions such as initiation, escalation, dependence, relapse, and cessation.
The scientific goals focus on moving beyond simple estimates of heritability toward a more realistic picture of risk and resilience, where genetic predispositions may be amplified, muted, or redirected by environmental contexts. Examples of the kinds of environmental factors that fit this emphasis include family and peer influences, early life stress and trauma, neighborhood and socioeconomic conditions, availability of substances, cultural and policy environments, and other exposures that vary across time. The FOA also highlights the importance of refining and deepening phenotype definitions, meaning investigators are encouraged to measure SUD-related outcomes in more precise, developmentally sensitive ways (for instance, by distinguishing stages of use and disorder, characterizing severity and symptom profiles, capturing trajectories over time, and carefully measuring comorbid psychiatric or medical conditions). By improving phenotyping and addressing methodological challenges in the field, the research supported under this announcement is intended to produce findings that are more interpretable and more useful for the next steps of science.
A key theme is translation potential. While this is not positioned as a clinical trial mechanism, the FOA frames gene-environment interplay research as a pathway to practical impact: identifying modifiable environmental risk factors, clarifying mechanisms of risk, improving prevention strategies, informing treatment approaches, and strengthening the foundation for future gene-finding and molecular studies. In other words, the expectation is that even small R03 projects can generate proof-of-concept evidence, novel analytic strategies, or preliminary data that enable larger follow-on work and, ultimately, improvements in public health responses to substance and alcohol problems.
From an administrative standpoint, this is an NIH grant mechanism in the R03 category, which typically supports short-duration, limited-budget projects. The listed award ceiling is $50,000. No cost sharing or matching is required. The FOA was posted February 5, 2015, with an original and current closing date of September 7, 2017, and an archive date of October 8, 2017, indicating the announcement is no longer active for new submissions under that specific posting window. The activity aligns with NIH programs under CFDA 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs), reflecting relevance to both alcohol and other drug research portfolios.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, state and local governments (including county, city/township, special districts, and independent school districts), public housing authorities/Indian housing authorities, and tribal entities (federally recognized and other than federally recognized), as well as tribally controlled colleges and universities. The FOA also explicitly includes a range of other eligible applicants such as historically underrepresented-serving institutions (for example, HBCUs, Hispanic-serving institutions, AANAPISISs, Alaska Native and Native Hawaiian-serving institutions), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations), which signals NIH interest in a diverse applicant pool and potentially diverse study populations and settings when scientifically appropriate.
For reference, the full announcement was hosted by NIH at http://grants.nih.gov/grants/guide/pa files/PA 15 111.html (as written in the source text), and NIH provided an Office of Extramural Research (OER) webmaster contact for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the Gene Environment Interplay in Substance Use Disorders (R03) funding opportunity?
It is an NIH discretionary grant announcement (Funding Opportunity Number PA-15-111) that supports smaller-scope research projects aimed at clarifying how genetic factors and environmental exposures work together to influence substance and alcohol use disorders (SUDs).
What is the main scientific focus of this FOA?
The FOA focuses on gene-environment interplay across the developmental course of SUDs. The intent is to move beyond simple estimates of heritability and better explain why some people initiate use, progress to disorder, develop comorbidities, experience adverse outcomes, relapse, recover, or stop using.
What does "gene-environment interplay" mean in the context of this opportunity?
In this FOA, gene-environment interplay refers to how genetic predispositions may be amplified, muted, or redirected depending on environmental contexts and exposures that can change across time and development.
What kinds of SUD-related transitions or stages does the FOA emphasize?
The FOA specifically highlights developmental transitions such as initiation, escalation, dependence, relapse, and cessation.
What kinds of study designs or analytic approaches are encouraged?
The FOA emphasizes the need for genetically informative study designs and analytic approaches that can untangle gene-environment interplay across development.
What types of environmental factors are considered relevant for this FOA?
Examples named in the FOA include family and peer influences, early life stress and trauma, neighborhood and socioeconomic conditions, availability of substances, cultural and policy environments, and other exposures that vary across time.
Does the FOA require or encourage more precise outcome measurement (phenotyping)?
Yes. The FOA highlights the importance of refining and deepening phenotype definitions by measuring SUD-related outcomes in more precise and developmentally sensitive ways.
What are examples of phenotyping improvements mentioned in the FOA?
Examples include distinguishing stages of use and disorder, characterizing severity and symptom profiles, capturing trajectories over time, and carefully measuring comorbid psychiatric or medical conditions.
Why does the FOA emphasize improved phenotyping and methodological work?
The stated goal is to produce findings that are more interpretable and more useful for next steps in the science by improving phenotype definitions and addressing methodological challenges in the field.
Is this opportunity intended to support research with translation potential?
Yes. A key theme is translation potential, with gene-environment interplay research framed as a pathway to practical impact.
What kinds of practical impacts are described in the FOA?
The FOA mentions identifying modifiable environmental risk factors, clarifying mechanisms of risk, improving prevention strategies, informing treatment approaches, and strengthening the foundation for future gene-finding and molecular studies.
Is this FOA positioned as a clinical trial mechanism?
No. The FOA notes that it is not positioned as a clinical trial mechanism.
What grant mechanism does this FOA use?
This opportunity uses the NIH R03 mechanism, which typically supports short-duration, limited-budget projects.
What is the funding cap or award ceiling listed for this opportunity?
The listed award ceiling is $50,000.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
When was the FOA posted, and what were the closing and archive dates?
The FOA was posted on February 5, 2015. The original and current closing date is listed as September 7, 2017, and the archive date is October 8, 2017.
Is this funding opportunity still active for new submissions?
Based on the listed closing date (September 7, 2017) and archive date (October 8, 2017), the announcement is no longer active for new submissions under that specific posting window.
Which NIH program areas or CFDA listings does this opportunity align with?
The activity aligns with NIH programs under CFDA 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and state and local governments (including county, city/township, special districts, and independent school districts).
Are tribal entities and tribally controlled institutions eligible?
Yes. The FOA includes tribal entities (federally recognized and other than federally recognized), public housing authorities/Indian housing authorities, and tribally controlled colleges and universities.
Are community-based, faith-based, or underrepresented-serving institutions included in eligibility?
Yes. The FOA explicitly includes historically underrepresented-serving institutions (such as HBCUs, Hispanic-serving institutions, AANAPISISs, Alaska Native and Native Hawaiian-serving institutions) and also includes faith-based or community-based organizations.
Are U.S. territories, regional organizations, federal agencies, or foreign organizations eligible?
Yes. The FOA lists eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations) as eligible applicants.
Where can the full NIH announcement be found?
The FOA text references the full announcement hosted by NIH at: http://grants.nih.gov/grants/guide/pa_files/PA-15-111.html (the source text presents the URL as written with spacing).
Who is the contact for access or linking issues related to the announcement?
NIH provided an Office of Extramural Research (OER) webmaster contact for access or linking issues: FBOWebmaster@OD.NIH.GOV.
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Applicants who have applied for this opportunity (PA 15 111) also looked into and applied for these:
| Funding Opportunity |
|---|
| Gene Environment Interplay in Substance Use Disorders (R21) Apply for PA 15 112 Funding Number: PA 15 112 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01) Apply for RFA DA 16 001 Funding Number: RFA DA 16 001 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Mentored Clinical Scientists Development Program Award in Drug Abuse and Addiction (K12) Apply for PAR 15 119 Funding Number: PAR 15 119 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Identification of Genetic and Genomic Variants by Next Gen in Sequencing Non human Animal Models (U01) Apply for PAR 15 120 Funding Number: PAR 15 120 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| BRAIN Initiative Optimization of Novel Tools and Technologies for Neuroscience Research (R44) Apply for PAR 15 121 Funding Number: PAR 15 121 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Functional Wellness in HIV Maximizing the Treatment Cascade (R01) Apply for PA 15 133 Funding Number: PA 15 133 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Functional Wellness in HIV Maximizing the Treatment Cascade (R21) Apply for PA 15 134 Funding Number: PA 15 134 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Administrative Supplements for Research on HIV/AIDS and Aging (Admin Supp) Apply for PA 15 137 Funding Number: PA 15 137 Agency: National Institutes of Health Category: Education Health Funding Amount: $100,000 |
| SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer Therapeutics, Imaging Technologies, Interventional Devices, Diagnostics and Prognostics Toward Commercialization (R44) Apply for RFA CA 15 010 Funding Number: RFA CA 15 010 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
| International Research Collaboration on Drug Abuse and Addiction Research (R03) Apply for PA 15 141 Funding Number: PA 15 141 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| International Research Collaboration on Drug Abuse and Addiction Research (R01) Apply for PA 15 142 Funding Number: PA 15 142 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| International Research Collaboration on Drug Abuse and Addiction Research (R21) Apply for PA 15 143 Funding Number: PA 15 143 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Limited Competition Revisions to Add Phase 2 Clinical Trials Program to Experimental Therapeutics Clinical Trials Network (ETCTN)(UM1) Apply for RFA CA 15 501 Funding Number: RFA CA 15 501 Agency: National Institutes of Health Category: Education Health Funding Amount: $560,000 |
| Cancer Research Education Grants Program Research Experiences (R25) Apply for PAR 15 152 Funding Number: PAR 15 152 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Cancer Research Education Grants Program Courses for Skills Development (R25) Apply for PAR 15 151 Funding Number: PAR 15 151 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Cancer Research Education Grants Program Curriculum or Methods Development (R25) Apply for PAR 15 150 Funding Number: PAR 15 150 Agency: National Institutes of Health Category: Education Health Funding Amount: $100,000 |
| Administrative Supplements to Promote Cancer Prevention and Control Research in Low and Middle Income Countries (Admin Supp) Apply for PAR 15 155 Funding Number: PAR 15 155 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions (R21) Apply for RFA CA 15 009 Funding Number: RFA CA 15 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions (R01) Apply for RFA CA 15 008 Funding Number: RFA CA 15 008 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Regional Medical Libraries for the National Network of Libraries of Medicine (UG4) Apply for RFA LM 15 003 Funding Number: RFA LM 15 003 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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