Opportunity Information: Apply for PA 11 237
Apply for PA 11 237
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Gene Environment Interplay in Substance Use Disorders (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Jul 31, 2014 and posted on Jul 19, 2011.
- Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education State governments County governments Special district governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.
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Opportunity Summary:
The Gene Environment Interplay in Substance Use Disorders (R03) opportunity (Funding Opportunity Number PA-11-237) is a National Institutes of Health discretionary grant sponsored by the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Its main purpose is to stimulate and broaden research that explains how genetic factors and environmental exposures work together to shape the start, development, and long-term outcomes of substance use disorders and alcohol use disorders. The announcement is grounded in the idea that decades of genetic epidemiology and molecular genetics have already shown these disorders are highly heritable and unfold across development, but that heritability alone does not explain who develops problems, when they appear, how they progress, or why outcomes vary so widely across individuals and contexts.
A central emphasis of the program is on research that can clarify gene-environment interplay across the full trajectory of substance and alcohol use disorders, from initiation and escalation through persistence, relapse, recovery, and desistance. The FOA highlights the need for genetically informative approaches that can tease apart the real contributions of genetics versus environment, and, importantly, how they combine. This includes studying how environmental conditions may amplify or buffer genetic risk, how genetic differences may shape sensitivity to particular environments, and how these processes influence comorbid conditions that commonly co-occur with SUDs (for example, other psychiatric disorders or behavioral health problems). The intent is to move beyond broad statements like "SUDs are heritable" and toward more specific, mechanistic knowledge about risk pathways that can ultimately inform prevention and intervention strategies.
The announcement also calls attention to improving and refining phenotypes, meaning more precise definitions and measurement of substance use disorder-related traits and outcomes. That can include developmental timing, symptom patterns, severity, progression, and adverse consequences, as well as intermediate traits that may sit between genes and clinical outcomes. Alongside improved phenotyping, the FOA explicitly recognizes that this area faces significant methodological challenges, so applications that thoughtfully address design and analytic complexities of gene-environment research are responsive. The broader promise described is that stronger gene-environment research can support multiple forms of translation, including better-targeted treatment and prevention approaches, stronger foundations for gene-finding efforts, and clearer connections to molecular studies that investigate biological mechanisms.
As an R03 mechanism, this is a small grant program intended to support focused, short-duration projects, pilot work, or other well-scoped studies that can generate useful evidence or establish feasibility for larger efforts. The listed award ceiling is $50,000. The opportunity does not require cost sharing or matching funds. It is categorized under health and education, and it aligns with CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
Eligibility is broad and includes many types of U.S. organizations as well as non-U.S. entities. Eligible applicants include public and private institutions of higher education (including public/state-controlled institutions), nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses), and multiple levels of government (state, county, city/township, special district, independent school districts), as well as public housing authorities/Indian housing authorities. Tribal governments (federally recognized and other than federally recognized) and tribal organizations are eligible, and the announcement also identifies a range of mission-focused institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs), along with faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions may apply, and non-domestic components of U.S. organizations are also eligible, which signals NIH interest in scientifically strong projects regardless of geography when appropriate.
Key administrative details in the posted record include an initial posted date of July 19, 2011, with later record updates, and the final listed closing date of January 7, 2015 (with an archive date of February 8, 2015). Additional information and the full announcement were provided through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-237.html. For technical issues accessing the announcement or linking to it, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Gene Environment Interplay in Substance Use Disorders (R03) - PA-11-237
What is the Gene Environment Interplay in Substance Use Disorders (R03) opportunity?
It is a National Institutes of Health (NIH) discretionary grant opportunity titled "Gene Environment Interplay in Substance Use Disorders (R03)" under Funding Opportunity Number (FON) PA-11-237. It uses the NIH R03 small grant mechanism to support focused, short-duration research projects.
Which NIH Institutes sponsor this funding opportunity?
The opportunity is sponsored by the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main purpose of this FOA?
The main purpose is to stimulate and broaden research that explains how genetic factors and environmental exposures work together (gene-environment interplay) to influence the initiation, development, and long-term outcomes of substance use disorders (SUDs) and alcohol use disorders (AUDs).
Why is the FOA focused on gene-environment interplay rather than heritability alone?
The announcement is grounded in the idea that while decades of genetic epidemiology and molecular genetics show SUDs and AUDs are highly heritable and unfold across development, heritability alone does not explain who develops problems, when they emerge, how they progress, or why outcomes vary across individuals and contexts. The FOA encourages research that moves beyond broad statements like "SUDs are heritable" to more specific, mechanistic understanding of risk pathways.
What parts of the substance/alcohol use disorder trajectory are emphasized?
The FOA emphasizes gene-environment interplay across the full trajectory of SUDs and AUDs, including initiation, escalation, persistence, relapse, recovery, and desistance.
What types of research questions are considered responsive to this opportunity?
Responsive projects include those that clarify how environmental conditions may amplify or buffer genetic risk, how genetic differences may shape sensitivity to particular environments, and how these combined processes affect the course and outcomes of SUDs and AUDs over time.
Does this FOA encourage research on comorbid or co-occurring conditions?
Yes. The opportunity explicitly notes interest in how gene-environment interplay influences comorbid conditions that commonly co-occur with SUDs, such as other psychiatric disorders or behavioral health problems.
What does the FOA mean by "genetically informative approaches"?
The FOA highlights the need for approaches that can help disentangle the contributions of genetics and environment, and how they combine. It stresses the importance of designs and analyses that can tease apart genetic versus environmental effects and illuminate their interplay.
What is meant by improving or refining phenotypes in this context?
Improving phenotypes refers to developing more precise definitions and measurement of SUD/AUD-related traits and outcomes. Examples referenced in the announcement include developmental timing, symptom patterns, severity, progression, adverse consequences, and intermediate traits that may sit between genes and clinical outcomes.
Are methodological and analytic challenges part of the FOA's focus?
Yes. The FOA explicitly recognizes that gene-environment research faces significant methodological challenges, and it indicates that applications that thoughtfully address design and analytic complexities are responsive.
How does the FOA describe the broader value or translation potential of this research?
The FOA describes potential benefits such as informing prevention and intervention strategies, enabling better-targeted treatment and prevention approaches, strengthening foundations for gene-finding efforts, and improving connections to molecular studies that investigate biological mechanisms.
What is the R03 mechanism and what is it intended to support here?
The R03 is an NIH small grant mechanism. In this opportunity, it is intended to support focused, short-duration projects, pilot work, or other well-scoped studies that can generate useful evidence or establish feasibility for larger efforts.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $50,000.
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching funds are not required.
Which subject areas does this opportunity fall under?
It is categorized under health and education and focuses on research related to substance use disorders and alcohol use disorders, specifically the interplay of genetic and environmental factors.
Which CFDA numbers are associated with this opportunity?
The opportunity aligns with CFDA 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
Who is eligible to apply?
Eligibility is broad. Eligible applicants include many types of U.S. organizations and also non-U.S. entities. Examples listed include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government.
Are government entities eligible, and if so which types?
Yes. Eligible government applicants include state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public housing authorities and Indian housing authorities.
Are Tribal governments and Tribal organizations eligible?
Yes. Federally recognized Tribal governments and other than federally recognized Tribal governments are eligible, and Tribal organizations are also eligible.
Are minority-serving and mission-focused institutions specifically included in eligibility?
Yes. The announcement identifies several such institutions and organizations as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed as eligible.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible applicants.
Are foreign institutions allowed to apply?
Yes. The opportunity states that foreign institutions may apply.
Are non-domestic components of U.S. organizations eligible?
Yes. Non-domestic components of U.S. organizations are listed as eligible, indicating NIH interest in scientifically strong projects regardless of geography when appropriate.
When was this funding opportunity posted and when did it close?
The posted record lists an initial posted date of July 19, 2011. The final listed closing date is January 7, 2015, and the archive date is February 8, 2015.
Where can applicants find the full announcement text?
The full announcement was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-11-237.html
Who should be contacted for technical issues accessing the announcement or links?
The listed contact for technical issues is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Browse more opportunities from the same category: Education Health
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Previous opportunity: Gene Environment Interplay in Substance Use Disorders (R21)
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| Pre Application for the 2012 NIDA Translational Avant Garde Award for Medication Development for the Treatment of Substance Use Disorders (X02) Apply for PAR 11 269 Funding Number: PAR 11 269 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Pre Application for the FY12 NIDA Avant Garde Award Program for HIV/AIDS Research (X02) Apply for PAR 11 256 Funding Number: PAR 11 256 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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| Drug Abuse Prevention Intervention Research (R21) Apply for PA 11 312 Funding Number: PA 11 312 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| mHealth Tools to Promote Effective PatientProvider Communication, Adherence to Treatment and Self Management of Chronic Diseases In Underserved Populations (R03) Apply for PA 11 331 Funding Number: PA 11 331 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| mHealth Tools to Promote Effective PatientProvider Communication, Adherence to Treatment and Self Management of Chronic Diseases In Underserved Populations (R01) Apply for PA 11 330 Funding Number: PA 11 330 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| mHealth Tools to Promote Effective PatientProvider Communication, Adherence to Treatment and Self Management of Chronic Diseases In Underserved Populations (R21) Apply for PA 11 332 Funding Number: PA 11 332 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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