Opportunity Information: Apply for PA 13 076
Apply for PA 13 076
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Gene Function Studies to Investigate Rare and Undiagnosed Diseases (Admin Supp)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jan 7, 2013 and posted on Jan 7, 2013.
- Applicants must submit their applications by Feb 26, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments Private institutions of higher education For profit organizations other than small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Gene Function Studies to Investigate Rare and Undiagnosed Diseases (Admin Supp) is a National Institutes of Health (NIH) administrative supplement opportunity designed to accelerate research on extremely rare and previously undiagnosed conditions identified through the NIH Undiagnosed Diseases Program (UDP). The central aim is to fund gene function studies carried out in collaboration with the UDP so researchers can move beyond simply finding a candidate genetic variant and instead test what that gene change actually does at the biochemical and physiological level. In practice, this means supporting work that clarifies the underlying genetics, biochemistry, and pathophysiology of newly diagnosed diseases coming out of the UDP pipeline, helping turn a genetic clue into a credible disease mechanism.
This opportunity reflects a broader shift in rare disease discovery, where diagnosis increasingly depends on combining genomic approaches (like sequencing and variant analysis) with experimental follow-up studies that establish causality and explain how a molecular disruption leads to clinical symptoms. The announcement emphasizes that gene function studies, when paired with genetic/genomic analyses and metabolic studies, have already improved diagnoses for very rare conditions and expanded scientific understanding of disease pathogenesis. The supplement structure signals that the NIH is trying to speed up this translation from gene discovery to functional insight, which can also lay groundwork for future therapeutic directions, biomarkers, or refined clinical categorization of newly described disorders.
The program is funded through the NIH Common Fund, a mechanism intended for cross-cutting, high-impact scientific initiatives that can influence multiple areas of health research rather than a single narrow field. That framing matters because the UDP model often uncovers conditions that do not fit existing diagnostic labels, and the functional work needed to interpret these findings can yield broadly useful methods, datasets, and biological insights. By supporting studies tied directly to UDP-identified cases, the program aims to maximize the likelihood that funded projects address real unmet diagnostic needs and produce findings that are immediately relevant to patients with rare or novel disorders.
Administratively, the funding opportunity number is PA-13-076, categorized as a discretionary grant mechanism under the health funding activity area (CFDA 93.310, Trans-NIH Research Support). It does not require cost sharing or matching. The announcement was posted January 7, 2013, with an original and current closing date of February 26, 2013, and an archive date of March 29, 2013. Because it is an administrative supplement, it is oriented toward adding support onto existing NIH-funded projects rather than functioning like a brand-new standalone award, with the goal of enabling current awardees to take on additional gene function work aligned with UDP discoveries.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants listed include state, county, city or township, and special district governments; independent school districts; federally recognized and other tribal governments and tribal organizations; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education as well as private institutions of higher education; nonprofits both with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (including small businesses and other for-profits); and additional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs). The announcement also explicitly allows non-domestic (non-U.S.) entities and foreign institutions to apply, and indicates that foreign components, as defined in the NIH Grants Policy Statement, are permitted. This wide eligibility reflects the reality that rare disease expertise, specialized model systems, and functional genomics capabilities are distributed across many sectors and countries.
For applicants or institutions seeking the full text, NIH provides the funding announcement link at http://grants.nih.gov/grants/guide/pa-files/PA-13-076.html. For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, including help for difficulty accessing the announcement electronically or problems linking to the funding notice.
Frequently Asked Questions (FAQs)
What is the “Gene Function Studies to Investigate Rare and Undiagnosed Diseases (Admin Supp)†opportunity?
It is a National Institutes of Health (NIH) administrative supplement opportunity intended to accelerate research on extremely rare and previously undiagnosed conditions identified through the NIH Undiagnosed Diseases Program (UDP). The focus is on funding gene function studies so teams can move beyond identifying a candidate genetic variant and test what the gene change does at biochemical and physiological levels.
What is the main purpose of this administrative supplement?
The central purpose is to support functional follow-up work that helps turn a genetic lead from UDP-identified cases into a credible disease mechanism by clarifying underlying genetics, biochemistry, and pathophysiology.
What kind of research does this opportunity emphasize?
The announcement emphasizes gene function studies carried out in collaboration with the UDP, particularly work that establishes causality and explains how molecular disruption leads to clinical symptoms. It also highlights pairing functional studies with genetic/genomic analyses and metabolic studies to improve diagnosis and expand understanding of disease pathogenesis.
Why does NIH focus on gene function studies for rare and undiagnosed diseases?
Because modern rare disease discovery increasingly depends on combining genomic approaches (such as sequencing and variant analysis) with experimental studies that confirm what a candidate variant actually does. This functional evidence can strengthen or confirm diagnoses and help explain disease biology.
How is this opportunity connected to the NIH Undiagnosed Diseases Program (UDP)?
The supplement is designed to support studies tied directly to cases and discoveries coming out of the UDP pipeline, with the intent that funded projects address unmet diagnostic needs and produce results that are immediately relevant to patients with rare or novel disorders.
What outcomes is NIH trying to speed up with this supplement?
NIH is trying to speed the translation from gene discovery to functional insight, supporting efforts that can clarify disease mechanisms and potentially lay groundwork for future therapeutic directions, biomarkers, or refined clinical categorization of newly described disorders.
What does “administrative supplement†mean in this context?
It means the opportunity is oriented toward adding support onto existing NIH-funded projects rather than operating as a brand-new standalone award. The intent is to enable current awardees to take on additional gene function work aligned with UDP discoveries.
What is the funding opportunity number for this announcement?
The funding opportunity number is PA-13-076.
Which NIH funding classification and activity area are associated with this opportunity?
It is categorized as a discretionary grant mechanism under the health funding activity area. The CFDA listing provided is 93.310, Trans-NIH Research Support.
How is this program funded within NIH?
The program is funded through the NIH Common Fund, which supports cross-cutting, high-impact scientific initiatives intended to influence multiple areas of health research.
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching is not required.
When was the announcement posted, and what were the closing and archive dates?
The announcement was posted on January 7, 2013. The original and current closing date listed is February 26, 2013. The archive date is March 29, 2013.
Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organizations. Eligible applicants listed include governmental entities (state, county, city or township, special district), independent school districts, tribal governments and tribal organizations (federally recognized and other), public housing authorities/Indian housing authorities, higher education institutions (public/state-controlled and private), nonprofits (with and without 501(c)(3) status, other than institutions of higher education), and for-profit organizations (including small businesses and other for-profits).
Are minority-serving institutions included in the eligible applicant types?
Yes. The eligible categories explicitly include Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs).
Can non-U.S. organizations or foreign institutions apply?
Yes. The announcement explicitly allows non-domestic (non-U.S.) entities and foreign institutions to apply.
Are foreign components allowed under this opportunity?
Yes. The announcement indicates that foreign components, as defined in the NIH Grants Policy Statement, are permitted.
Why is eligibility so broad for this supplement?
The announcement’s wide eligibility reflects that rare disease expertise, specialized model systems, and functional genomics capabilities are distributed across many sectors and countries.
Where can applicants find the full funding announcement text?
The full NIH funding announcement is available at: http://grants.nih.gov/grants/guide/pa-files/PA-13-076.html.
Who should be contacted if there are technical problems accessing the announcement?
For access or technical issues (such as difficulty accessing the announcement electronically or problems linking to the notice), the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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