Opportunity Information: Apply for PAR 12 249
Apply for PAR 12 249
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Genetic and Genomic Analysis of Xenopus (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 25, 2012 and posted on Jul 25, 2012.
- Applicants must submit their applications by Sep 30, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: County governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Public housing authorities/Indian housing authorities City or township governments Special district governments For profit organizations other than small businesses State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Genetic and Genomic Analysis of Xenopus (R21) opportunity (PAR-12-249) was a National Institutes of Health (NIH) funding announcement led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), and the Trans-NIH Xenopus Working Group (TXWG). Its central goal was to strengthen and expand the usefulness of Xenopus (frog) systems as vertebrate models for biomedical research by supporting early-stage, exploratory projects. The emphasis was on investigator-initiated ideas that either build enabling capabilities for the broader Xenopus community or apply newly available capabilities in ways that quickly open up new biological questions.
Projects under this FOA were expected to enhance the detection and characterization of genes, pathways, and phenotypes relevant to development and organ formation (organogenesis), as well as core cell biology processes such as cell division, signaling, and cell migration. In practical terms, the announcement encouraged applications that would create or significantly improve genetic, genomic, or proteomic tools and resources considered high-priority and broadly useful. That could include things like new experimental methods, community-ready reagents, data resources, pipelines, or other infrastructure that makes Xenopus experiments more powerful, more scalable, or more informative for understanding vertebrate biology and disease-related mechanisms.
A second major track welcomed proposals that take advantage of recently developed genetic, genomic, or proteomic technologies to advance these same scientific goals, especially when the technologies being proposed had not previously been used in Xenopus research. In other words, the FOA was not limited to tool-building; it also supported proof-of-concept applications that demonstrate how emerging methods can be used in Xenopus to reveal new biology. This reflects the R21 program’s general intent: to fund innovative, potentially high-impact directions that may be too early for larger, longer-term mechanisms, but that can generate compelling feasibility data, resources, and momentum for subsequent studies.
Administratively, this was a discretionary grant opportunity under the NIH umbrella, categorized within health-related research and tied to CFDA numbers 93.865 (Child Health and Human Development Extramural Research) and 93.173 (Research Related to Deafness and Communication Disorders), reflecting the participating institutes. The award ceiling listed was $200,000, and there was no cost-sharing or matching requirement. The FOA was posted and created on July 25, 2012, with an original and final closing date of September 30, 2014, and an archive date of October 31, 2014, meaning it is no longer active but remains available for reference.
Eligibility was broad and inclusive. Eligible applicants included a wide range of U.S. entities such as state and local governments, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, and certain housing authorities and school districts, along with additional categories like faith-based or community-based organizations and regional organizations. The FOA explicitly allowed non-U.S. (foreign) institutions to apply, permitted non-U.S. components of U.S. organizations, and allowed foreign components as defined by NIH policy, signaling an intent to draw from the full international Xenopus research ecosystem. The NIH provided a link to the full announcement text on the NIH Grants Guide, and general technical contact for accessing or linking issues was routed through the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is the name and identifier of this grant opportunity?
The opportunity is titled "Genetic and Genomic Analysis of Xenopus (R21)" and it was issued as PAR-12-249.
Which agency offered this funding opportunity?
This was a National Institutes of Health (NIH) funding announcement.
Which NIH institutes and groups led or participated in the announcement?
The announcement was led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), and the Trans-NIH Xenopus Working Group (TXWG).
What was the overall purpose of this FOA?
The central goal was to strengthen and expand the usefulness of Xenopus (frog) systems as vertebrate models for biomedical research by supporting early-stage, exploratory projects.
What type of NIH grant mechanism was used?
This opportunity used the NIH R21 mechanism, which is intended for early-stage, exploratory and potentially high-impact projects that can generate feasibility data, resources, and momentum for later studies.
What kinds of projects were emphasized?
The FOA emphasized investigator-initiated ideas that either (1) build enabling capabilities for the broader Xenopus community or (2) apply newly available capabilities in ways that quickly open up new biological questions.
What scientific areas were projects expected to advance?
Projects were expected to enhance the detection and characterization of genes, pathways, and phenotypes relevant to development and organ formation (organogenesis), as well as core cell biology processes such as cell division, signaling, and cell migration.
Was the FOA limited to tool-building projects only?
No. In addition to tool and resource development, the FOA also supported proof-of-concept studies that apply recently developed genetic, genomic, or proteomic technologies in Xenopus, particularly when those technologies had not previously been used in Xenopus research.
What kinds of tools or resources did the announcement encourage applicants to develop?
The announcement encouraged applications that would create or significantly improve high-priority, broadly useful genetic, genomic, or proteomic tools and resources. Examples mentioned include new experimental methods, community-ready reagents, data resources, pipelines, or other infrastructure that makes Xenopus experiments more powerful, scalable, or informative.
What is meant by "enabling capabilities" for the Xenopus community in this FOA?
Based on the description, enabling capabilities refer to shared tools, reagents, data assets, methods, pipelines, or infrastructure that other Xenopus researchers can use to expand what is feasible in Xenopus experiments and accelerate discovery across the field.
What is the second major "track" of projects described in the FOA?
A second major track welcomed proposals that take advantage of recently developed genetic, genomic, or proteomic technologies to advance Xenopus-based biomedical research goals, especially when the technologies proposed had not previously been used in Xenopus research.
How does this FOA describe the intended value of R21-funded work?
It highlights innovation and potentially high impact, supporting ideas that may be too early for larger, longer-term mechanisms but can produce compelling feasibility data, resources, and momentum for subsequent studies.
What was the maximum award amount listed?
The award ceiling listed was $200,000.
Was cost sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
What CFDA numbers were associated with this opportunity?
The opportunity was tied to CFDA 93.865 (Child Health and Human Development Extramural Research) and 93.173 (Research Related to Deafness and Communication Disorders).
When was the FOA posted and created?
It was posted and created on July 25, 2012.
What were the original and final closing dates?
The original closing date and the final closing date were both September 30, 2014.
Is this funding opportunity still active?
No. It is no longer active. The archive date was October 31, 2014, and it remains available for reference.
Who was eligible to apply?
Eligibility was described as broad and inclusive, including many U.S. entity types such as state and local governments, public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), small businesses, certain housing authorities, and school districts, as well as faith-based or community-based organizations and regional organizations.
Were foreign (non-U.S.) institutions eligible to apply?
Yes. The FOA explicitly allowed non-U.S. (foreign) institutions to apply.
Could a U.S. organization include non-U.S. components under this FOA?
Yes. The FOA permitted non-U.S. components of U.S. organizations and also allowed foreign components as defined by NIH policy.
What model organism did this FOA focus on?
The FOA focused on Xenopus (frog) systems as vertebrate models for biomedical research.
Where could applicants find the full announcement text?
The NIH provided a link to the full announcement text on the NIH Grants Guide.
Who was listed as the general technical contact for access or linking issues?
General technical contact for accessing or linking issues was routed through the NIH Office of Extramural Research (OER) webmaster.
Browse more opportunities from the same category: Health Income Security and Social Services
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Previous opportunity: Secondary Analyses and Archiving of Social and Behavioral Datasets in Aging (R03)
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