Genetic and Genomic Resources for Emerging Non Mammalian Model Organisms (R24) | Apply Online

Opportunity Summary:

The Genetic and Genomic Resources for Emerging Non-Mammalian Model Organisms (R24) funding opportunity, issued by the National Institute of General Medical Sciences (NIGMS) within the National Institutes of Health (NIH), supports investigator-initiated projects that build the kinds of shared research resources needed to turn promising non-mammalian species into practical, widely usable model systems. The central aim is to accelerate comparative genomics and functional genomics by funding the development of genetic tools and genomic resources that a broader research community can use, especially for organisms that are newer to mainstream biomedical and basic science research.

A key expectation is that the proposed organism is already far enough along in genomic characterization to make resource-building feasible and impactful. Specifically, the typical organism should have a publicly available draft genome sequence with at least 5X coverage. Beyond having a baseline genome draft, the organism should be compelling as a research model for understanding fundamental biological questions, including basic cellular and molecular biology, development, and behavior. In practice, this means the organism should either already be used as a model by a growing community or have clear potential to become one because it offers unique advantages for answering important biological questions.

The work supported under this announcement is intentionally flexible because the needs of emerging model systems vary widely. One project might focus on creating genetic mapping resources or validated markers, another might develop community-accessible genomic databases or annotation resources, and another might produce standardized genetic tools that make experiments reproducible across laboratories. The announcement emphasizes that the nature and scope of projects can differ substantially from application to application, and the program anticipates corresponding differences in budget size, project duration, and overall award structure. Awards are made competitively, and both the total dollars awarded and the number of awards ultimately depend on how many applications are submitted, how strong they are scientifically, and how their proposed costs and timelines align with program priorities.

This opportunity uses the NIH Research Resource (R24) mechanism, which is designed for resource-building efforts that serve a broader scientific community rather than only a single laboratory. Under this mechanism, applicants may request up to $250,000 per year in direct costs, for a maximum project period of up to four years. The grants are explicitly non-renewable under this announcement, signaling that the program is intended to catalyze resource creation within a defined window rather than provide indefinite, ongoing operational support.

The opportunity is categorized as a discretionary grant in the health funding area and is associated with CFDA number 93.859 (Biomedical Research and Research Training). There is no cost-sharing or matching requirement, which can simplify budgeting and reduce barriers for applicants who may not have institutional funds available to offset project expenses.

Eligibility is broad and includes many types of organizations that commonly participate in NIH funding, reflecting the idea that valuable resource development can occur in different settings. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both those with 501(c)(3) status and certain nonprofits without 501(c)(3) status outside of higher education), for-profit organizations (including small businesses and other for-profits), state governments, and Native American tribal governments and organizations. The announcement also explicitly includes a range of institution types often highlighted in federal programs, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and U.S. territories or possessions. Non-U.S. entities (foreign organizations) are also listed as eligible, broadening the potential for internationally relevant model systems and resource-sharing efforts.

For reference and administrative details, the funding opportunity number is PA-07-457, and it was posted on December 3, 2008. The original and current closing date listed is January 7, 2011, and the archive date is February 7, 2011, indicating that this specific announcement is historical rather than currently open. The full announcement was hosted through the NIH Grants Guide (the link is provided in the source text). For technical issues accessing the announcement, the listed contact point is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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