Opportunity Information: Apply for PA 07 413
Apply for PA 07 413
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Genetic Epidemiology of Substance Use Disorders(R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 24, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities State governments Small businesses County governments For profit organizations other than small businesses Special district governments Private institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) City or township governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Genetic Epidemiology of Substance Use Disorders (R01) funding opportunity (PA 07 413) is a National Institutes of Health (NIH) discretionary grant program designed to support full-scale research projects that use genetic epidemiology to better understand substance use disorders (SUDs) and alcohol use disorders (AUD). Its central goal is to expand and strengthen the use of genetically informed population and family-based methods to answer core questions about why SUDs/AUD develop, how they change over time, and how genetic and environmental influences interact across the lifespan. The FOA is aimed at studies of drug and alcohol abuse and dependence, with an emphasis on generating insights that can ultimately improve prevention, treatment, and biological discovery efforts.
A major theme of the opportunity is developmental understanding. Applicants are encouraged to apply genetic epidemiologic approaches to clarify how substance involvement begins, escalates, remits, and relapses, and to map the developmental trajectories that lead to diagnosable disorders. This includes work that can separate which observed patterns are more strongly tied to inherited liability versus environmental exposures, and how those influences may shift at different ages or stages (for example, early initiation versus chronic dependence). In parallel, the FOA highlights the importance of distinguishing genetic risk from environmental risk in both the onset and maintenance of SUDs/AUD, including designs and analyses that can address shared family environment, peer effects, neighborhood context, stress and trauma, comorbid mental health conditions, and other non-genetic contributors that can complicate causal interpretation.
Another key priority is phenotyping: broadening, refining, and improving how SUDs/AUD are defined and measured for research purposes. The announcement signals interest in moving beyond simple diagnostic labels when appropriate, such as using dimensional symptom measures, endophenotypes, intermediate traits, patterns of use, craving, withdrawal profiles, or cross-substance liability factors. The intent is to support phenotypic approaches that better match the underlying biology and real-world clinical heterogeneity, thereby improving the accuracy and usefulness of genetic epidemiologic findings. The FOA also explicitly connects etiologic research to translation, encouraging studies that can guide the application of genetic and environmental risk knowledge to treatment development, prevention strategies, gene-finding efforts, and downstream molecular studies.
The mechanism of support is the NIH Research Project Grant (R01), which is generally used for mature, hypothesis-driven projects that require substantial resources and multi-year support. This R01 FOA runs in parallel with two companion announcements of the same scientific scope but different grant mechanisms: PA 07 414 for the R03 (typically smaller, short-term projects such as pilots or secondary analyses) and PA 07 415 for the R21 (often used for exploratory or high-risk/high-reward work). In practical terms, applicants should choose the mechanism that best fits the scale and readiness of their proposed study, with PA 07 413 intended for larger, fully developed projects.
Funding levels and the number of awards are not fixed in the announcement; instead, awards are contingent on NIH appropriations, the availability of funds, and the submission of a sufficient number of scientifically strong applications. The FOA uses multiple receipt dates (rather than a single deadline), meaning applications could be submitted on the relevant NIH receipt cycles listed in the full announcement.
Eligibility is broad. A wide range of U.S. organizations can apply, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses and other for-profit organizations (other than small businesses), state and local governments (including counties, cities, townships, special districts), independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and organizations. The opportunity also states that foreign institutions are eligible, eligible federal agencies may apply, and faith-based or community-based organizations may apply, which expands the potential applicant pool beyond traditional academic settings.
The program is associated with NIH program areas reflected in CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). Cost sharing or matching is not required. The opportunity was posted July 24, 2007, and later archived October 8, 2010, with the official full announcement historically available through the NIH Grants Guide (PA 07 413). For technical access issues, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): Genetic Epidemiology of Substance Use Disorders (R01) - PA 07 413
What is the Genetic Epidemiology of Substance Use Disorders (R01) funding opportunity?
PA 07 413 is a National Institutes of Health (NIH) discretionary grant opportunity that uses the NIH Research Project Grant (R01) mechanism to support full-scale research projects applying genetic epidemiology to substance use disorders (SUDs) and alcohol use disorders (AUD).
What is the central goal of this FOA?
The main goal is to expand and strengthen genetically informed population-based and family-based methods to answer core questions about why SUDs/AUD develop, how they change over time, and how genetic and environmental influences interact across the lifespan.
What research topics does the FOA emphasize?
The FOA emphasizes studies of drug and alcohol abuse and dependence, especially projects that can generate insights that ultimately improve prevention, treatment, and biological discovery efforts.
What does the FOA mean by a developmental focus?
The announcement highlights research that clarifies how substance involvement begins, escalates, remits, and relapses, and how developmental trajectories lead to diagnosable disorders. It also encourages work examining whether genetic and environmental influences shift at different ages or stages (for example, early initiation versus chronic dependence).
Does this FOA encourage separating genetic and environmental influences?
Yes. A major emphasis is distinguishing genetic risk from environmental risk in the onset and maintenance of SUDs/AUD, including approaches that address potential confounding factors and improve causal interpretation.
What kinds of environmental or non-genetic factors are specifically mentioned?
The FOA points to shared family environment, peer effects, neighborhood context, stress and trauma, comorbid mental health conditions, and other non-genetic contributors that can complicate causal interpretation.
What is meant by "phenotyping" in this announcement?
Phenotyping refers to broadening, refining, and improving how SUDs/AUD are defined and measured in research. The FOA signals interest in moving beyond simple diagnostic labels when appropriate.
What are examples of phenotypes the FOA is interested in beyond diagnostic categories?
The announcement mentions dimensional symptom measures, endophenotypes, intermediate traits, patterns of use, craving, withdrawal profiles, and cross-substance liability factors.
Why does the FOA encourage improved phenotyping?
The intent is to support phenotypic approaches that better match underlying biology and real-world clinical heterogeneity, improving the accuracy and usefulness of genetic epidemiologic findings.
How does the FOA connect etiologic research to translation?
The FOA explicitly encourages studies that can guide applying knowledge of genetic and environmental risk to treatment development, prevention strategies, gene-finding efforts, and downstream molecular studies.
What grant mechanism does PA 07 413 use?
PA 07 413 uses the NIH Research Project Grant (R01) mechanism, which is generally used for mature, hypothesis-driven projects that require substantial resources and multi-year support.
Are there related or companion funding announcements?
Yes. Two companion announcements have the same scientific scope but use different mechanisms: PA 07 414 for the R03 mechanism and PA 07 415 for the R21 mechanism.
How are the R03 and R21 mechanisms characterized in the announcement?
The R03 is described as typically supporting smaller, short-term projects such as pilots or secondary analyses. The R21 is described as often supporting exploratory or high-risk/high-reward work.
How should an applicant choose among R01, R03, and R21 for this topic area?
Applicants are expected to choose the mechanism that fits the scale and readiness of the proposed study, with PA 07 413 intended for larger, fully developed projects.
Are the funding levels and number of awards fixed?
No. The announcement indicates funding levels and the number of awards are not fixed and depend on NIH appropriations, availability of funds, and the submission of a sufficient number of scientifically strong applications.
Does this FOA have a single application deadline?
No. The FOA uses multiple receipt dates rather than a single deadline, meaning applications can be submitted on the relevant NIH receipt cycles listed in the full announcement.
Who is eligible to apply?
Eligibility is broad and includes many U.S. organization types, foreign institutions, eligible federal agencies, and faith-based or community-based organizations (as stated in the opportunity).
What U.S. organization types are included in the eligibility list?
The eligibility list includes public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); small businesses; other for-profit organizations (other than small businesses); state and local governments (including counties, cities, townships, and special districts); independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and organizations.
Are foreign institutions eligible?
Yes. The opportunity states that foreign institutions are eligible.
Are faith-based or community-based organizations eligible?
Yes. The opportunity states that faith-based or community-based organizations may apply.
Does the FOA require cost sharing or matching funds?
No. The opportunity states that cost sharing or matching is not required.
What CFDA numbers are associated with this program area?
The FOA is associated with CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs).
When was the opportunity posted, and what is its current status?
The opportunity was posted on July 24, 2007, and was archived on October 8, 2010.
Where was the official full announcement historically available?
The official full announcement was historically available through the NIH Grants Guide under PA 07 413.
Who is the listed contact for technical access issues?
For technical access issues, the point of contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 413) also looked into and applied for these:
| Funding Opportunity |
|---|
| Genetic Epidemiology of Substance Use Disorders (R03) Apply for PA 07 414 Funding Number: PA 07 414 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Genetic Epidemiology of Substance Use Disorders(R21) Apply for PA 07 415 Funding Number: PA 07 415 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| Outcomes, Cost Effectiveness and the Decision Making Process to Use Complementary and Alternative Medicine (R01) Apply for PAR 08 045 Funding Number: PAR 08 045 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Understanding and Preventing Brain Tumor Dispersal (R01) Apply for PAS 08 048 Funding Number: PAS 08 048 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Understanding and Preventing Brain Tumor Dispersal (R21) Apply for PAS 08 049 Funding Number: PAS 08 049 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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