Opportunity Information: Apply for RFA DK 15 016
Apply for RFA DK 15 016
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "GenitoUrinary Development Molecular Anatomy Project (GUDMAP) Human Tissue Core (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Jul 23, 2015 and posted on Jul 23, 2015.
- Applicants must submit their applications by Nov 9, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Independent school districts Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) Human Tissue Core (U24) grant opportunity, issued by the National Institutes of Health (NIH) under Funding Opportunity Number RFA-DK-15-016, was designed to support a centralized resource that could reliably supply high-quality human genitourinary tissues to the broader GUDMAP consortium. At its core, the announcement called for a Human Tissue Core that would function as the operational backbone for acquiring, coordinating, quality-controlling, and distributing human kidney and lower urinary tract specimens to multiple “Atlas Project†sites. In practical terms, NIH was looking for a group that could serve as the trusted hub connecting tissue source sites with research teams generating molecular and anatomical atlases of human genitourinary development and biology.
This opportunity used the cooperative agreement mechanism (U24), meaning it was not a hands-off research grant but a collaborative, milestone-driven program where NIH would expect substantial involvement in oversight and coordination. The Human Tissue Core was expected to identify and manage one or more tissue source sites, putting in place the administrative, ethical, and logistical systems needed to ensure that samples were obtained and handled appropriately. A major emphasis was placed on tissue quality: the Core would be responsible for implementing standards and procedures so that specimens provided to consortium investigators would be consistent, well-documented, and fit for downstream atlas-generation work. Beyond procurement and quality assurance, the Core also had to manage distribution, ensuring that human kidney and lower urinary tract samples were delivered to Atlas Project sites in a manner that preserved integrity and supported cross-site comparability.
From an applicant and administrative standpoint, the program fell under the NIH’s mission space tied to diabetes, digestive, and kidney diseases (CFDA 93.847), and it was categorized in the listing as “Food and Nutrition; Health,†reflecting NIH’s broader cataloging rather than the specific scientific focus. The award had an annual budget ceiling of $400,000, and there was no cost-sharing or matching requirement, which typically simplifies budgeting for institutions by not requiring them to contribute institutional funds as a condition of the award. The announcement was posted on July 23, 2015, with an application deadline of November 9, 2015, and it was later archived on December 10, 2015.
Eligibility was broad across many U.S.-based organizational types, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses and other for-profit organizations (excluding for-profits that are small businesses in some contexts, though here for-profits other than small businesses were explicitly listed), and a wide range of government entities such as state, county, city/township, special district governments, and public housing authorities/Indian housing authorities. The announcement also explicitly recognized eligibility for organizations serving specific populations and missions, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and certain regional organizations. Foreign institutions were not eligible to apply as primary applicants, but non-U.S. components of U.S. organizations were allowed, and foreign components (as defined by NIH policy) were permitted, reflecting NIH’s common approach of allowing certain international elements when justified while keeping the prime award domestic.
Overall, the opportunity was essentially about building and running a high-reliability tissue operations center for the GUDMAP consortium. Rather than funding a single lab’s discovery project, it aimed to enable many downstream atlas and mapping efforts by ensuring that human genitourinary specimens could be obtained ethically, tracked and documented properly, maintained at high quality, and distributed efficiently to multiple research sites working under the GUDMAP umbrella. For reference and full details, NIH pointed applicants to the official guide notice page at http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-15-016.html and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is the GUDMAP Human Tissue Core (U24) funding opportunity?
This NIH opportunity (Funding Opportunity Number RFA-DK-15-016) supported a centralized Human Tissue Core for the GenitoUrinary Development Molecular Anatomy Project (GUDMAP). The goal was to create a reliable hub that could acquire, coordinate, quality-control, and distribute high-quality human genitourinary tissues to multiple GUDMAP Atlas Project sites.
What problem was NIH trying to solve with this award?
NIH was aiming to ensure that multiple atlas-generation teams could work from consistent, well-documented, high-quality human kidney and lower urinary tract specimens. Instead of each site independently sourcing tissues (with variable handling and documentation), the Human Tissue Core would standardize procurement, quality assurance, and distribution across the consortium.
What is the main purpose of the Human Tissue Core?
The Human Tissue Core was intended to function as the operational backbone that connects tissue source sites with GUDMAP Atlas Project investigators. Its primary purpose was to reliably supply human kidney and lower urinary tract samples that are ethically obtained, properly tracked, consistently processed, and suitable for downstream molecular and anatomical atlas work.
What kinds of human tissues were included?
The opportunity focused on human kidney and lower urinary tract specimens for use by GUDMAP Atlas Project sites.
Who would receive the tissues distributed by the Core?
Tissues were to be distributed to multiple GUDMAP consortium investigators, specifically the Atlas Project sites generating molecular and anatomical atlases of human genitourinary development and biology.
What activities and responsibilities were expected of the awardee?
Based on the opportunity description, the awardee was expected to:
- Identify and manage one or more tissue source sites.
- Put administrative, ethical, and logistical systems in place for appropriate sample acquisition and handling.
- Implement tissue quality standards and procedures to ensure specimens are consistent and fit for downstream atlas-generation work.
- Coordinate distribution so samples are delivered in a manner that preserves integrity and supports cross-site comparability.
Why was tissue quality emphasized so strongly?
The Core was meant to supply specimens to multiple sites doing atlas work, so inconsistencies in collection, handling, documentation, or shipping could undermine cross-site comparability. NIH emphasized standards and procedures so specimens would be consistent, well-documented, and usable for downstream molecular and anatomical mapping.
What does it mean that this was a U24 cooperative agreement?
A U24 cooperative agreement indicates a collaborative, milestone-driven award where NIH expects substantial involvement in oversight and coordination. In other words, this was not described as a hands-off research grant; NIH anticipated active engagement in how the program is managed and executed.
Was this opportunity intended to fund a single discovery research project?
No. The description framed this as building and operating a high-reliability tissue operations center for the GUDMAP consortium, enabling many downstream atlas and mapping efforts by supplying well-controlled human specimens.
Which NIH mission area and CFDA listing applied to this opportunity?
The opportunity was tied to NIH’s mission space connected to diabetes, digestive, and kidney diseases and listed under CFDA 93.847. It was also categorized in the listing as "Food and Nutrition; Health" as part of NIH cataloging.
What was the maximum annual budget allowed?
The award had an annual budget ceiling of $400,000.
Was cost sharing or matching required?
No. The opportunity stated there was no cost-sharing or matching requirement.
When was the announcement posted and when were applications due?
The announcement was posted on July 23, 2015, and the application deadline was November 9, 2015.
Is this funding opportunity still active?
No. The announcement was later archived on December 10, 2015.
Who was eligible to apply?
Eligibility was broad across many U.S.-based organization types, including:
- Public and private institutions of higher education
- Nonprofits (with and without 501(c)(3) status)
- Small businesses
- Other for-profit organizations (explicitly listed)
- Government entities such as state, county, city/township, special district governments, and public housing authorities/Indian housing authorities
Were organizations that serve specific populations or missions explicitly included as eligible?
Yes. The opportunity explicitly recognized eligibility for organizations including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and certain regional organizations.
Could a foreign institution apply as the primary applicant?
No. Foreign institutions were not eligible to apply as primary applicants.
Were any international components allowed at all?
Yes. The opportunity allowed non-U.S. components of U.S. organizations, and foreign components (as defined by NIH policy) were permitted, even though the prime awardee needed to be a domestic (U.S.-eligible) organization.
What did NIH expect regarding ethics and handling of human tissues?
The Core was expected to establish the administrative and ethical systems needed to ensure tissues were obtained and handled appropriately. The description emphasized ethical acquisition, documentation, quality control, and logistics that protect sample integrity.
What did NIH mean by "cross-site comparability"?
It refers to the need for tissues delivered to multiple Atlas Project sites to be consistent in quality and documentation so data generated across different sites can be meaningfully compared as part of consortium-wide atlas efforts.
Where could applicants find the official funding announcement details?
NIH directed applicants to the official guide notice page: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-15-016.html
Who should be contacted for access or linking issues to the announcement?
The opportunity referenced NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
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