Opportunity Information: Apply for RFA HG 10 015
Apply for RFA HG 10 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Genome Sequencing and Analysis Centers (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Dec 14, 2010 and posted on Dec 14, 2010.
- Applicants must submit their applications by Mar 3, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $90,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments Small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities County governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Genome Sequencing and Analysis Centers (U54) opportunity (Funding Opportunity Number RFA-HG-10-015) is a National Institutes of Health program run through the National Human Genome Research Institute (NHGRI) to renew and extend NHGRI's large-scale sequencing program. The solicitation is built around maintaining and advancing a national-scale capacity for high-throughput genome sequencing and the downstream analysis needed to turn raw sequence data into broadly useful scientific products. It is explicitly positioned as a continuation of an established program that helped deliver the human genome sequence, produced genome sequences for many biomedical and comparative genomics model organisms, mapped genetic variation across human populations in detail, and launched major medical sequencing efforts aimed at finding genomic changes involved in inherited diseases and cancer.
A central goal of the renewal is to keep pushing the field's long-running trajectory of higher output at lower cost, so that sequencing can be applied to harder and more complex biomedical questions over time. The announcement highlights, as an example of these harder questions, the genetic basis of complex inherited disease, where many variants and biological pathways may be involved rather than a single causal mutation. Alongside sheer throughput, NHGRI emphasizes the importance of extracting biological meaning from DNA-based changes, so projects supported under these U54 cooperative agreements are expected to contribute to understanding how genomic variation and other DNA-level differences influence biological systems.
The solicitation also makes clear that the science and technology are evolving quickly, and that the program expects to evolve with them. It calls out the increasing challenge of identifying and designing new types of large-scale sequencing projects that take advantage of emerging high-throughput sequencing capabilities to answer the most compelling next-generation questions. In parallel, it underscores that bioinformatics, data integration, and analytical interpretation are becoming more demanding as datasets grow in size and complexity. In practice, this frames the funded centers as not only production engines for sequencing, but also as hubs for computational methods, pipelines, and integration strategies that can handle and combine large genomic datasets and translate them into coherent resources for the broader research community.
The anticipated project period described in the announcement is four years, during which NHGRI expects both the number and the variety of large-scale sequencing "products" to expand. The notice signals that this growth will require additional flexibility across program components, which implies a need for centers that can adapt rapidly to changing priorities, new technologies, and new categories of genomic datasets and deliverables. Because the award mechanism is a U54 cooperative agreement, the program should be understood as involving substantial NIH programmatic involvement and coordination compared with a typical investigator-initiated grant, with an emphasis on meeting shared program goals and producing outputs at scale.
A notable administrative requirement is that applicants to this U54 program must submit a parallel application to the Initiative to Maximize Research Education in Genomics (R25), referenced in the announcement via PAR-09-245. This signals that, alongside sequencing and analysis production, NHGRI expects an organized training or research education component tied to genomics, likely aimed at workforce development and broader participation in genomics research, aligned with the center's activities.
From the funding and logistics perspective, the opportunity is categorized as discretionary and uses the cooperative agreement instrument type. The activity category is health, and the CFDA number is 93.172 (Human Genome Research). The estimated total funding level listed is $90,000,000, and there is no cost sharing or matching requirement stated. The opportunity was posted and created on December 14, 2010, with an original and current closing date of March 3, 2011, and an archive date of April 3, 2011.
Eligibility is broad and includes many organization types, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses, other for-profit organizations (other than small businesses), independent school districts, and multiple levels of government (state, county, city/township, special district), as well as public housing authorities/Indian housing authorities. It also includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized). The additional eligibility information further lists Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
For applicants who want the full official details, the announcement provides an additional information link to the NIH grants guide page for RFA-HG-10-015. The contact information provided is oriented toward technical access issues and directs users to the NIH Office of Extramural Research (OER) webmaster email (FBOWebmaster@OD.NIH.GOV) for problems accessing or linking to the funding announcement.
Frequently Asked Questions (FAQs)
1) What is the Genome Sequencing and Analysis Centers (U54) opportunity?
It is a National Institutes of Health (NIH) funding opportunity run through the National Human Genome Research Institute (NHGRI) to renew and extend NHGRI's large-scale sequencing program. It focuses on sustaining and advancing national-scale, high-throughput genome sequencing capacity and the downstream analysis needed to convert raw sequence data into broadly useful scientific products.
2) What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number is RFA-HG-10-015.
3) Which NIH Institute runs this opportunity?
The opportunity is administered by the National Human Genome Research Institute (NHGRI) within NIH.
4) What is the main purpose of renewing this program?
The renewal is intended to maintain and advance a national-scale capability for high-throughput genome sequencing and analysis, and to keep pushing the field toward higher output at lower cost so sequencing can be applied to increasingly complex biomedical questions.
5) How is this solicitation positioned in relation to earlier NHGRI efforts?
It is explicitly described as a continuation of an established program that contributed to delivering the human genome sequence, producing genome sequences for biomedical and comparative genomics model organisms, mapping genetic variation across human populations, and launching major medical sequencing efforts related to inherited diseases and cancer.
6) What kinds of scientific challenges does the program want to address over time?
The announcement highlights the push to apply sequencing to harder and more complex biomedical questions. One example given is the genetic basis of complex inherited disease, where many variants and biological pathways may contribute rather than a single causal mutation.
7) Is the program only about generating sequence data?
No. Alongside sequencing throughput, the opportunity emphasizes the need to extract biological meaning from DNA-level changes. Funded centers are expected to contribute to understanding how genomic variation and other DNA-based differences influence biological systems.
8) Why does the announcement emphasize bioinformatics and data integration?
Because datasets are growing in size and complexity, the solicitation underscores that bioinformatics, data integration, and analytical interpretation are becoming more demanding. The funded centers are framed as hubs for computational methods, pipelines, and integration strategies that can combine large genomic datasets and translate them into coherent resources for the broader research community.
9) How does the program address rapid changes in sequencing technology and science?
The solicitation states that science and technology are evolving quickly and that the program expects to evolve with them. It calls out the increasing challenge of identifying and designing new types of large-scale sequencing projects that take advantage of emerging high-throughput sequencing capabilities to answer compelling next-generation questions.
10) What is the anticipated project period?
The anticipated project period described is four years.
11) What does NHGRI expect to happen during the four-year period?
NHGRI expects both the number and the variety of large-scale sequencing "products" to expand during the project period, and it indicates this growth will require additional flexibility across program components.
12) What does the U54 cooperative agreement mechanism imply for how the award operates?
Because the award mechanism is a U54 cooperative agreement, the program is described as involving substantial NIH programmatic involvement and coordination compared with a typical investigator-initiated grant, with an emphasis on meeting shared program goals and producing outputs at scale.
13) Is there a required training or education component tied to this U54 application?
Yes. Applicants must submit a parallel application to the Initiative to Maximize Research Education in Genomics (R25), referenced as PAR-09-245. This signals an expectation for an organized training or research education component aligned with the center's genomics activities.
14) What is the CFDA number associated with this opportunity?
The CFDA number is 93.172 (Human Genome Research).
15) What is the funding type and overall category listed for this opportunity?
The opportunity is categorized as discretionary, uses the cooperative agreement instrument type, and is listed under the health activity category.
16) What is the estimated total funding level?
The estimated total funding level listed is $90,000,000.
17) Is cost sharing or matching required?
No cost sharing or matching requirement is stated in the information provided.
18) When was the opportunity posted, and what were the closing dates?
It was posted and created on December 14, 2010. The original and current closing date listed is March 3, 2011. The archive date is April 3, 2011.
19) Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with and without 501(c)(3) status), small businesses, other for-profit organizations (other than small businesses), independent school districts, and multiple levels of government (state, county, city/township, special district). It also includes public housing authorities/Indian housing authorities, Native American tribal governments (federally recognized), and tribal organizations (other than federally recognized).
20) Are there additional organization types listed as eligible?
Yes. Additional eligibility information includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
21) Where can applicants find the official full announcement details?
The opportunity provides a link to the NIH grants guide page for RFA-HG-10-015 for full official details.
22) Who should be contacted for technical issues accessing or linking to the announcement?
For problems accessing or linking to the funding announcement, users are directed to email the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
23) What kinds of outputs are centers expected to deliver?
The announcement describes "large-scale sequencing products" and emphasizes converting raw sequencing data into broadly useful scientific products, along with computational pipelines and integrated resources that serve the broader research community.
24) Does the program emphasize national-scale capacity?
Yes. A core theme is maintaining and advancing a national-scale capacity for high-throughput genome sequencing and the downstream analysis needed to support large, complex genomic datasets.
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