Opportunity Information: Apply for RFA RM 16 001
Apply for RFA RM 16 001
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310,.
- This funding opportunity was created on Jan 13, 2016 and posted on Jan 13, 2016.
- Applicants must submit their applications by Mar 31, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $12,600,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses.
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Opportunity Summary:
The Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24) funding opportunity (RFA-RM-16-001) is a cooperative agreement issued by the U.S. Department of Health and Human Services through NIH (listed here as HHS-NIH11). It was created and posted on January 13, 2016, with an application closing date of March 31, 2016. The award mechanism is a U24 cooperative agreement, which typically means NIH expects to have substantial programmatic involvement in coordinating goals, milestones, data quality expectations, and integration with broader program infrastructure rather than operating as a hands-off grant.
The core purpose of the FOA is to stand up one or two genome sequencing centers that can produce whole genome sequencing (WGS) data at high quality and at scale, and then deliver the associated variant data (for example, called variants and related annotations/metrics) from a large number of human specimens. The specimens are tied to two major pediatric focus areas: structural birth defects and childhood cancers. In practice, the emphasis is on rapid, high-throughput generation of consistent, reliable genomic data that can be used broadly by the research community, rather than sequencing isolated small cohorts for a single laboratory's specific hypothesis.
A central feature of the opportunity is that the sequencing and variant outputs are intended to become part of a larger data resource maintained under the Gabriella Miller Kids First Pediatric Research Program. That program-level framing matters because it highlights the intent to build a durable, reusable dataset that supports many downstream studies. On the birth defects side, the resulting genomes and variant calls are meant to help researchers investigate genetic etiology, meaning the underlying genetic causes and contributing factors that may drive or predispose to structural anomalies. On the childhood cancer side, the data are meant to help clarify the genetic contribution to pediatric cancers, which can include inherited susceptibility, de novo variation, and tumor-related genomic features depending on the specimen types and study design that the program supports.
Because the FOA aims to establish a limited number of centers (one or two), it is essentially investing in centralized capacity: standardized pipelines, consistent quality control, and operational readiness to process many samples efficiently. The expectation is not only sequencing, but also generation of variant data suitable for inclusion in a shared research resource, which implies strong attention to reproducibility, documentation, and compatibility with program data standards so that independent researchers can meaningfully use the outputs without having to rebuild the analysis from scratch.
Eligibility is broad and includes multiple types of government entities (state, county, city/township, and special district governments), public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments and other eligible tribal organizations, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those particular categories), and for-profit organizations (other than small businesses). The activity category is health, and the listing includes CFDA numbers 93.310 (and also references 93.310 in the source). The stated award ceiling is $12,600,000, indicating the opportunity is designed to support substantial sequencing center operations, infrastructure, and the personnel and systems required to generate and deliver a high-volume, high-quality genomic dataset aligned with Kids First program objectives.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24)" and is identified as RFA-RM-16-001.
Which federal agency is offering this opportunity?
It is a cooperative agreement issued by the U.S. Department of Health and Human Services (HHS) through the National Institutes of Health (NIH) (listed as HHS-NIH11).
What type of award mechanism is this?
The award mechanism is a U24 cooperative agreement.
What does a U24 cooperative agreement generally imply about NIH involvement?
Based on the description provided, a U24 cooperative agreement typically means NIH expects substantial programmatic involvement, such as coordinating goals and milestones, setting data quality expectations, and ensuring integration with broader program infrastructure, rather than operating as a hands-off grant.
When was the opportunity posted?
The opportunity was created and posted on January 13, 2016.
What was the application closing date?
The application closing date was March 31, 2016.
What is the primary purpose of this funding opportunity?
The core purpose is to establish one or two genome sequencing centers capable of producing high-quality whole genome sequencing (WGS) data at scale and delivering associated variant data from a large number of human specimens.
How many genome sequencing centers does the FOA aim to support?
The FOA is intended to stand up a limited number of centers, specifically one or two, emphasizing centralized capacity and standardization.
What kinds of sequencing data are expected from the funded centers?
The opportunity emphasizes generating whole genome sequencing (WGS) data that is high quality and produced at high throughput (at scale).
What additional outputs are expected beyond sequencing reads?
In addition to sequencing, the centers are expected to deliver variant data, including examples such as called variants and related annotations/metrics.
What pediatric research areas are the specimens associated with?
The specimens are tied to two major pediatric focus areas: structural birth defects and childhood cancers.
Is the emphasis on small, single-lab projects or broad community resources?
The emphasis is on rapid, high-throughput generation of consistent, reliable genomic data intended for broad use by the research community, rather than sequencing isolated small cohorts for a single laboratory's specific hypothesis.
How will the sequencing and variant outputs be used within the Kids First program?
The sequencing and variant outputs are intended to become part of a larger data resource maintained under the Gabriella Miller Kids First Pediatric Research Program, supporting many downstream studies.
What is the intended scientific value for the structural birth defects focus area?
For structural birth defects, the genomes and variant calls are meant to help researchers investigate genetic etiology, meaning the underlying genetic causes and contributing factors that may drive or predispose to structural anomalies.
What is the intended scientific value for the childhood cancers focus area?
For childhood cancers, the data are meant to help clarify the genetic contribution to pediatric cancers, including examples mentioned such as inherited susceptibility, de novo variation, and tumor-related genomic features (depending on specimen types and study design supported by the program).
Why does the FOA emphasize centralized sequencing centers?
Because the FOA aims to establish only one or two centers, it is investing in centralized capacity that supports standardized pipelines, consistent quality control, and operational readiness to process many samples efficiently.
What does "compatibility with program data standards" mean in this context?
From the information provided, it implies the outputs should be produced with strong attention to reproducibility, documentation, and alignment with Kids First program expectations so independent researchers can meaningfully use the data without rebuilding analyses from scratch.
What is the activity category for this opportunity?
The activity category is Health.
What CFDA number is associated with this opportunity?
The listing includes CFDA 93.310 (and references 93.310 in the source).
What is the stated award ceiling?
The stated award ceiling is $12,600,000.
What types of organizations are eligible to apply?
Eligibility is broad and includes:
- Government entities: state governments, county governments, city/township governments, and special district governments
- Higher education: public and state-controlled institutions of higher education, and private institutions of higher education
- Tribal entities: federally recognized Native American tribal governments and other eligible tribal organizations
- Nonprofits: 501(c)(3) nonprofits and non-501(c)(3) nonprofits (in the categories specified, excluding institutions of higher education for those nonprofit categories)
- For-profit organizations: for-profit organizations other than small businesses
Are small businesses eligible under the for-profit category?
No. The eligibility statement specifies for-profit organizations other than small businesses.
What does it mean that the program is building a "durable, reusable dataset"?
Based on the description, it means the sequencing and variant data are intended to serve as a long-lasting shared resource within the Kids First program, enabling many different researchers and studies to use the same high-quality, consistently processed genomic dataset.
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