Opportunity Information: Apply for RFA HG 13 004

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Genomic Medicine Pilot Demonstration Projects (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
  • This funding opportunity was created on Apr 1, 2013 and posted on Apr 1, 2013.
  • Applicants must submit their applications by Jul 17, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education City or township governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Small businesses Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The Genomic Medicine Pilot Demonstration Projects (U01) opportunity (Funding Opportunity Number RFA-HG-13-004) was a National Institutes of Health (NIH) funding announcement intended to build a coordinated group, or consortium, of pilot demonstration projects in genomic medicine. The central goal was practical: to show that it is feasible to take a specific patients genomic findings and incorporate them into real clinical care, while also developing and refining the methods needed to make that integration reliable, repeatable, and clinically useful. In other words, the program was not just about generating genomic data; it was about figuring out how to use genomic results in routine healthcare settings in ways that meaningfully inform patient management.

This announcement used the Cooperative Agreement mechanism (U01), which typically signals an active partnership between NIH and the funded teams rather than a hands-off grant. The cooperative structure generally fits programs where multiple projects need to align on shared goals, contribute comparable outputs, and coordinate approaches so that lessons learned are transferable beyond a single institution. In this case, NIH aimed to support collaborative pilot projects that together could test workflows for bringing genomic information into clinical decision-making, identify implementation barriers, and develop approaches to overcome them, such as clinical processes, informatics strategies, and methods for returning and acting on results.

The total estimated funding level listed was approximately $3,000,000. The announcement fell under the NIH activity category of Health and was associated with CFDA number 93.172 (Human Genome Research). There was no cost sharing or matching requirement, meaning applicants were not required to provide non-federal funds as a condition of the award.

Eligibility was broad across U.S.-based organizations, spanning many types of public and private entities. Eligible applicants included nonprofits (both 501(c)(3) and certain non-501(c)(3) nonprofits), public and state-controlled institutions of higher education, private institutions of higher education, for-profit organizations other than small businesses, small businesses, independent school districts, and a variety of government entities such as city or township governments, county governments, state governments, special district governments, and public housing authorities/Indian housing authorities. The eligibility language also explicitly encompassed a range of mission- or population-focused institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, and eligible federal agencies. Tribal organizations were included both for federally recognized tribal governments and certain other tribal entities. U.S. territories or possessions were also included. At the same time, the announcement clearly excluded non-U.S. entities: foreign institutions could not apply, and foreign components were not allowed, including non-domestic components of U.S. organizations, consistent with NIH policy definitions.

Key timeline details show that the FOA was posted on April 1, 2013, with an original and current closing date of July 17, 2013, and it was later archived on August 17, 2013. These dates indicate it was a time-limited opportunity with a single submission window rather than an open, ongoing program.

For additional details, NIH provided an official web link to the full announcement at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-13-004.html, along with contact information for technical difficulties accessing or linking to the announcement via the NIH Office of Extramural Research (OER) webmaster email addresses listed in the notice.

Frequently Asked Questions (FAQs)

What is the Genomic Medicine Pilot Demonstration Projects (U01) opportunity?

It was an NIH funding opportunity announcement called the Genomic Medicine Pilot Demonstration Projects (U01), Funding Opportunity Number (FON) RFA-HG-13-004. The program was designed to create a coordinated group (a consortium) of pilot demonstration projects focused on genomic medicine in real clinical settings.

What was the main goal of this program?

The central goal was to demonstrate that it is feasible to take a specific patient's genomic findings and incorporate them into real clinical care. The program also aimed to develop and refine methods so that this integration could be reliable, repeatable, and clinically useful.

Was the program mainly about generating genomic data?

No. The emphasis was not simply on producing genomic data, but on figuring out how to use genomic results in routine healthcare in ways that meaningfully inform patient management.

What kind of award mechanism did NIH use for this opportunity?

The announcement used the Cooperative Agreement mechanism (U01). This typically indicates an active partnership between NIH and the funded teams, rather than a fully hands-off approach.

Why was a cooperative agreement (U01) used?

A cooperative structure generally fits programs where multiple projects need to align on shared goals, produce comparable outputs, and coordinate approaches so lessons learned can transfer beyond a single institution. For this opportunity, NIH aimed to support collaborative pilot projects that could test workflows, identify implementation barriers, and develop approaches to overcome those barriers.

What types of activities or outcomes were these projects expected to address?

Based on the program description, the pilot projects were intended to test workflows for bringing genomic information into clinical decision-making, identify barriers to implementation, and develop strategies to overcome them. Examples mentioned include clinical processes, informatics strategies, and methods for returning and acting on genomic results.

What was the estimated total funding level for this opportunity?

The total estimated funding level listed in the announcement was approximately $3,000,000.

What NIH activity category was associated with this opportunity?

The opportunity fell under the NIH activity category of Health.

What CFDA number was associated with the announcement?

The CFDA number listed was 93.172 (Human Genome Research).

Was cost sharing or matching required?

No. The announcement stated there was no cost sharing or matching requirement, meaning applicants were not required to provide non-federal funds as a condition of award.

Who was eligible to apply?

Eligibility was broad across U.S.-based organizations. Eligible applicants included nonprofits (both 501(c)(3) and certain non-501(c)(3) nonprofits), public and state-controlled institutions of higher education, private institutions of higher education, for-profit organizations other than small businesses, small businesses, independent school districts, and many government entities (for example, city or township governments, county governments, state governments, special district governments, and public housing authorities/Indian housing authorities).

Were mission- or population-focused institutions included in eligibility?

Yes. The eligibility language explicitly encompassed organizations and institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also included faith-based or community-based organizations, regional organizations, and eligible federal agencies.

Are tribal organizations eligible?

Yes. Tribal organizations were included, covering federally recognized tribal governments as well as certain other tribal entities described in the eligibility section.

Are U.S. territories or possessions eligible to apply?

Yes. U.S. territories or possessions were included in eligibility.

Are foreign institutions eligible to apply?

No. The announcement excluded non-U.S. entities: foreign institutions could not apply.

Are foreign components allowed as part of an application?

No. Foreign components were not allowed, including non-domestic components of U.S. organizations, consistent with NIH policy definitions referenced in the opportunity description.

When was the funding opportunity posted?

The FOA was posted on April 1, 2013.

What was the application due date (closing date)?

The original and current closing date listed was July 17, 2013.

Was this an ongoing opportunity or a time-limited submission?

It was time-limited with a single submission window, as indicated by the specific posted and closing dates rather than an open or rolling timeline.

When was the announcement archived?

The opportunity was archived on August 17, 2013.

Where can applicants find the official full announcement?

NIH provided an official web link to the full announcement at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-13-004.html.

Who should be contacted for technical problems accessing or linking to the FOA?

The announcement provided contact information for technical difficulties via the NIH Office of Extramural Research (OER) webmaster email address(es) listed in the notice.

What does it mean that NIH planned a consortium or coordinated group?

In this context, it means NIH intended multiple funded pilot projects to work in a coordinated way, aligning on shared goals and producing learnings that could be compared and transferred across institutions rather than remaining isolated within a single site.

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