Opportunity Information: Apply for RFA HG 13 012
Apply for RFA HG 13 012
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Genomics of Gene Regulation (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Aug 6, 2013 and posted on Aug 6, 2013.
- Applicants must submit their applications by Nov 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments Independent school districts Small businesses Native American tribal governments (Federally recognized) City or township governments Public and State controlled institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Genomics of Gene Regulation (GGR) (U01) funding opportunity (RFA-HG-13-012) is a National Institutes of Health (NIH) cooperative agreement designed to launch a coordinated research initiative focused on how genomic DNA sequence helps control gene regulation at the level of gene networks. The central scientific motivation is a long-term functional genomics goal: to work out the "rules" that govern gene regulatory networks and to understand how those rules shape cellular behavior, development, and disease. Instead of treating gene regulation as a collection of isolated switches, the initiative emphasizes how many sequence-based functional elements collectively act to control a defined set of genes that drive a particular biological phenomenon, with RNA abundance (and potentially transcript structure) serving as the main readout of regulatory output.
A key feature of this FOA is its emphasis on substantial methodological advancement rather than small, incremental tweaks to existing approaches. Applicants are expected to propose demonstration projects that develop and validate improved models of gene regulatory networks, specifically targeting the genome-proximal layer of regulation, meaning regulatory logic that can be tied directly to DNA sequence and its functional elements. The intended outcome is progress toward a major capability in genomics: being able to start from DNA sequence and reliably predict when a gene will be expressed and at what levels, in the context of a particular cell state. In practical terms, the FOA is pushing the field toward predictive, testable models that connect sequence features to transcriptional consequences in realistic biological contexts.
The program is structured as a consortium, with the expectation that funded projects will not operate as isolated efforts. Instead, they are meant to accelerate the pace of discovery through coordination, including shared or harmonized analytical methods and the integration of functional genomic datasets. Because the award mechanism is a U01 cooperative agreement, NIH typically anticipates an active partnership role with awardees compared to a standard research grant, with coordination and collaboration being central to the initiative's design.
From an administrative standpoint, this was a discretionary grant opportunity using the cooperative agreement funding instrument, categorized under health and associated with CFDA 93.172 (Human Genome Research). The FOA was posted on August 6, 2013, with an application closing date of November 15, 2013, and an estimated total funding level of $10,000,000. There was no cost sharing or matching requirement stated.
Eligibility was broad and included many types of domestic applicants such as state and local governments, public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), small businesses and other for-profit organizations, independent school districts, and tribal governments and organizations. The FOA also explicitly allowed non-U.S. entities (foreign organizations and foreign institutions) to apply, permitted non-U.S. components of U.S. organizations, and allowed foreign components as defined under NIH Grants Policy. Additional eligible applicant categories included HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, among others.
The official announcement and further details were provided through the NIH grants page at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-13-012.html, with contact support referenced via the NIH Office of Extramural Research (OER) webmaster email for access or linking issues.
FAQs: Genomics of Gene Regulation (GGR) (U01) - RFA-HG-13-012
What is this funding opportunity?
This opportunity is the Genomics of Gene Regulation (GGR) (U01) funding opportunity announcement (FOA) RFA-HG-13-012, issued by the National Institutes of Health (NIH). It uses the U01 cooperative agreement mechanism to support a coordinated research initiative focused on how genomic DNA sequence helps control gene regulation at the level of gene networks.
What is the main scientific goal of the initiative?
The long-term functional genomics goal is to work out the "rules" that govern gene regulatory networks and understand how those rules shape cellular behavior, development, and disease. The initiative is aimed at moving toward predictive, testable models that connect DNA sequence and sequence-based functional elements to transcriptional outcomes.
What does the FOA mean by focusing on gene networks rather than isolated switches?
Rather than treating gene regulation as a set of individual, independent regulatory switches, the initiative emphasizes how many sequence-based functional elements collectively control a defined set of genes that drive a particular biological phenomenon.
What is the primary readout for regulatory output in this program?
RNA abundance is described as the main readout of regulatory output, with the possibility that transcript structure may also be considered as part of the readout.
What type of projects are applicants expected to propose?
Applicants are expected to propose demonstration projects that develop and validate improved models of gene regulatory networks, with a specific focus on the genome-proximal layer of regulation (regulatory logic that can be tied directly to DNA sequence and its functional elements).
What does "genome-proximal layer of regulation" mean in this FOA?
In this context, it refers to regulatory logic that can be linked directly to DNA sequence and sequence-based functional elements, rather than downstream regulatory effects that cannot be directly traced back to sequence features.
Is the FOA looking for incremental improvements or major advances?
The FOA emphasizes substantial methodological advancement rather than small, incremental tweaks to existing approaches. Projects are expected to push beyond minor refinements and demonstrate meaningful improvements in modeling gene regulatory networks.
What is the intended capability the program is trying to enable?
The FOA describes progress toward a major genomics capability: starting from DNA sequence and reliably predicting when a gene will be expressed and at what levels, in the context of a particular cell state.
How are funded projects expected to work together?
The program is structured as a consortium. Funded projects are not expected to operate as isolated efforts; instead, the initiative is designed to accelerate discovery through coordination, including shared or harmonized analytical methods and integration of functional genomic datasets.
What is a U01 cooperative agreement in practical terms for this program?
Because the award mechanism is a U01 cooperative agreement, NIH typically anticipates a more active partnership role with awardees than in a standard research grant, and coordination and collaboration are central to the initiative's design.
What type of grant is this categorized as?
This was described as a discretionary grant opportunity using the cooperative agreement funding instrument, categorized under health.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.172 (Human Genome Research).
When was the FOA posted and when was the application due?
The FOA was posted on August 6, 2013, and the application closing date was November 15, 2013.
What was the estimated total funding level?
The estimated total funding level stated for this FOA was $10,000,000.
Was cost sharing or matching required?
No cost sharing or matching requirement was stated for this opportunity.
Who was eligible to apply?
Eligibility was broad and included many types of domestic applicants, such as state and local governments, public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), small businesses and other for-profit organizations, independent school districts, and tribal governments and organizations.
Were foreign organizations allowed to apply?
Yes. The FOA explicitly allowed non-U.S. entities (foreign organizations and foreign institutions) to apply, permitted non-U.S. components of U.S. organizations, and allowed foreign components as defined under NIH Grants Policy.
Are minority-serving institutions included in the eligible applicant types?
Yes. The FOA listed additional eligible applicant categories including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, among others.
Where can applicants find the official announcement and full details?
The official announcement and further details were provided through the NIH grants page at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-13-012.html.
Who is the contact for access or linking issues related to the announcement page?
Contact support for access or linking issues was referenced via the NIH Office of Extramural Research (OER) webmaster email.
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