Opportunity Information: Apply for RFA DK 16 013

  • The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "George M. O'Brien Urology Cooperative Research Centers Program (U54)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847,.
  • This funding opportunity was created on Dec 04, 2015 and posted on Dec 04, 2015.
  • Applicants must submit their applications by Feb 22, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:

The George M. O'Brien Urology Cooperative Research Centers Program (U54) is a National Institutes of Health (NIH) cooperative agreement funding opportunity from HHS/NIH (listed as HHS-NIH11) aimed at building a coordinated, multidisciplinary research “center” focused on benign urologic diseases and disorders. The program is designed to bring basic scientists and clinical investigators together in a structured way so that discoveries about disease mechanisms can be translated into better clinical tools. At its core, the FOA is looking for a center-level effort that can help clarify how benign urologic conditions start and progress (their etiology and development), and then use that knowledge to improve treatments, diagnostics, and prevention strategies in areas that align with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

A defining feature of this opportunity is that it uses the U54 cooperative agreement mechanism, meaning the funded group is expected to work collaboratively with NIDDK rather than operating as a fully independent investigator-initiated grant. The FOA emphasizes active cooperation: awardees are expected to help facilitate research collaborations and interactions within their own center, across other funded centers (if any), and with the broader urologic research community. The intent is to create a strong communication and coordination structure that accelerates progress, avoids siloed work, and raises overall research quality through shared planning and cross-fertilization of ideas.

Beyond conducting research, the program is also framed as a national resource for the urology research community. In practice, that means the center is expected to have a footprint that extends outside its home institution, supporting the field through collaboration, shared expertise, and a cooperative environment that others can plug into. The FOA also highlights an educational and training-related role: the center should provide educational enrichment opportunities for scientists who are choosing to pursue research careers in benign urology. This signals that NIDDK is not only funding a set of projects, but also investing in long-term capacity building in the benign urologic disease research space.

Administratively, the opportunity is identified as RFA-DK-16-013 under the Catalog of Federal Domestic Assistance (CFDA) numbers 93.847. It is categorized as a discretionary funding opportunity and falls under the broad activity category of health (also tagged within food and nutrition/health categories in the source data). The award information provided indicates an award ceiling of $1,000,000, with an expectation of 1 award, which suggests a competitive selection for a single center or a very limited number of centers during that cycle.

Eligibility is broad and includes many types of applicant organizations. Eligible applicants listed include public entities (state, county, city/township governments, special district governments), independent school districts, public housing authorities/Indian housing authorities, tribal governments and tribal organizations, public and private institutions of higher education, nonprofits with or without 501(c)(3) status (outside of universities as well), for-profit organizations other than small businesses, small businesses, and other entities as allowed by additional eligibility language in the full announcement. This wide eligibility range reflects the center concept: successful applications often involve substantial institutional infrastructure and the ability to coordinate multidisciplinary teams and external collaborations, regardless of whether the lead organization is academic, nonprofit, or another qualified entity.

Key dates in the posting show the FOA was created and posted on December 4, 2015, with an application closing date of February 22, 2016 (original and current closing date are the same in the source data). Taken together, the opportunity is essentially a center-building initiative intended to strengthen and connect benign urology research nationally, support collaborative translational science, and improve patient-relevant outcomes by advancing understanding, diagnosis, prevention, and treatment of benign urologic disorders through coordinated excellence and active partnership with NIDDK.

Frequently Asked Questions (FAQs)

What is the George M. O'Brien Urology Cooperative Research Centers Program (U54)?

It is an NIH cooperative agreement funding opportunity that supports the creation of a coordinated, multidisciplinary research "center" focused on benign urologic diseases and disorders. The center concept is meant to bring basic science and clinical research together so that findings about disease mechanisms can be translated into improved clinical tools.

Which federal agency is offering this funding opportunity?

The opportunity is offered by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), and is associated with NIDDK (the National Institute of Diabetes and Digestive and Kidney Diseases). It is listed in the source data as HHS-NIH11.

What is the main purpose of this program?

The program aims to build a center-level effort that clarifies how benign urologic conditions begin and progress (etiology and development) and uses that knowledge to improve diagnostics, treatments, and prevention strategies in areas aligned with the NIDDK mission.

What types of health conditions are the focus of this program?

The focus is on benign urologic diseases and disorders (non-cancerous urologic conditions). The program specifically emphasizes understanding disease mechanisms and translating that understanding into patient-relevant advances.

What does it mean that this is a U54 cooperative agreement?

A U54 is a cooperative agreement mechanism, which means the funded center is expected to work collaboratively with NIDDK rather than operating as a fully independent, investigator-initiated award. The FOA emphasizes active cooperation and coordination as a defining feature.

How is this program different from a typical research grant?

This opportunity is framed as a center-building initiative rather than a stand-alone project. It emphasizes structured collaboration among basic and clinical investigators, coordination across centers (if multiple are funded), and active engagement with NIDDK, along with a broader national-resource role for the field.

What kinds of collaboration are expected from awardees?

Awardees are expected to facilitate research collaborations and interactions within their own center, across other funded centers (if any), and with the broader urologic research community. The intent is to strengthen communication, avoid siloed work, and accelerate progress through shared planning and cross-fertilization of ideas.

Is the funded center expected to serve as a resource beyond its home institution?

Yes. The FOA describes the program as a national resource for the urology research community, meaning the center is expected to have a footprint beyond its home institution and support the field through collaboration, shared expertise, and a cooperative environment that others can connect with.

Does the program include training or educational expectations?

Yes. The FOA highlights an educational enrichment role, indicating that the center should provide educational and training-related opportunities for scientists pursuing research careers in benign urology.

What is the FOA number for this opportunity?

The funding opportunity is identified as RFA-DK-16-013.

What CFDA number is associated with this opportunity?

The Catalog of Federal Domestic Assistance (CFDA) number listed is 93.847.

What is the maximum award amount (award ceiling)?

The award ceiling listed is $1,000,000.

How many awards are expected?

The source data indicates an expectation of 1 award, suggesting a highly competitive selection for a single center (or a very limited number of centers) for that cycle.

What type of funding opportunity is this categorized as?

It is categorized as a discretionary funding opportunity and falls under the broad activity category of health (also tagged within food and nutrition/health categories in the source data).

Who is eligible to apply?

Eligibility is broad and includes many organization types, including:

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public housing authorities / Indian housing authorities
  • Tribal governments and tribal organizations
  • Public and private institutions of higher education
  • Nonprofits with or without 501(c)(3) status (outside of universities as well)
  • For-profit organizations other than small businesses
  • Small businesses
  • Other entities as permitted by additional eligibility language in the full announcement

Does the broad eligibility mean any organization can realistically lead the center?

The eligibility list is broad, but the opportunity is described as a center-level effort that typically requires substantial infrastructure and the ability to coordinate multidisciplinary teams and external collaborations. The description suggests that successful applicants will be those able to support and manage a coordinated research center model.

What is the application deadline?

The application closing date listed is February 22, 2016 (the original and current closing date are the same in the provided source data).

When was this funding opportunity posted?

The FOA was created and posted on December 4, 2015.

What are the core scientific goals emphasized in the program description?

The program emphasizes understanding how benign urologic conditions start and progress, and translating those insights into improved clinical tools. It specifically points to improving treatment, diagnostics, and prevention strategies aligned with NIDDK priorities.

Is translational research a key part of the program?

Yes. The FOA description explicitly emphasizes structured collaboration between basic scientists and clinical investigators so that discoveries about mechanisms can be translated into better clinical tools.

Why does the FOA emphasize communication and coordination?

The stated intent is to accelerate progress, reduce siloed work, improve research quality, and encourage shared planning and cross-fertilization of ideas across investigators, centers, and the broader urologic research community.

What institute mission alignment is referenced?

The FOA states that the center's activities should align with the mission of NIDDK, particularly around advancing knowledge and tools relevant to benign urologic diseases and disorders.

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