Opportunity Information: Apply for PA 11 011
Apply for PA 11 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Getting from Genes to Function in Lung Disease, NHLBI (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Oct 25, 2010 and posted on Oct 25, 2010.
- Applicants must submit their applications by May 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Special district governments Private institutions of higher education City or township governments County governments State governments Small businesses Native American tribal governments (Federally recognized) Independent school districts Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Heart, Lung, and Blood Institute (NHLBI) grant opportunity titled "Getting from Genes to Function in Lung Disease, NHLBI (R01)" (Funding Opportunity Number PA-11-011) was a discretionary research grant program designed to push lung disease genetics beyond discovery and into biological understanding. The central goal was to support R01 Research Project Grant applications that take gene(s) and specific genetic variants already implicated in lung diseases through genome-wide association studies (GWAS) or other human genetic approaches, and then rigorously determine what those genes and variants actually do in the context of disease. In other words, it was aimed at closing the gap between statistical genetic association and real, mechanistic insight into lung disease biology.
Projects under this FOA were expected to focus on characterizing the function of identified genes and variants and defining their pathobiological roles. The emphasis was not on finding new associations, but on moving from signals in human genetic datasets to actionable functional knowledge: how a variant affects gene expression or protein function, which molecular pathways are altered, what happens in relevant lung cell types, and how these changes contribute to disease initiation, progression, or severity. The announcement explicitly encouraged integrated, cross-disciplinary strategies, meaning proposals were expected to combine methods and expertise across fields such as human genetics, molecular and cellular biology, physiology, bioinformatics, systems biology, and disease modeling. Strong applications would typically connect multiple levels of evidence, for example linking a GWAS locus to a causal variant, to a target gene, to a specific cellular mechanism in the lung, and finally to measurable disease-related phenotypes.
The funding mechanism was the NIH R01, which supports a defined research project led by a principal investigator and carried out by a research team over a multi-year period. The activity category was health research, and the relevant CFDA listing was 93.838 (Lung Diseases Research). The opportunity did not require cost sharing or matching, which is typical for NIH investigator-initiated research grants.
In terms of who could apply, eligibility was broad and included many types of U.S. and non-U.S. organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses, though small businesses were also listed among eligible applicants), and various government entities at the city, county, state, and special district levels. The FOA also explicitly included a wide set of institutions and communities often highlighted in federal eligibility language, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, Native American tribal governments (federally recognized and other than federally recognized), regional organizations, and U.S. territories or possessions. Foreign (non-U.S.) entities were also listed as eligible.
Administratively, the FOA was posted on October 25, 2010, with an original and current closing date of May 7, 2011, and it was archived on June 7, 2011. The administering agency was the National Institutes of Health, specifically NHLBI. The full announcement was available via the NIH grants guide page listed in the additional information link (http://grants.nih.gov/grants/guide/pa-files/PA-11-011.html). For access issues or link problems, the notice directed applicants to the NIH Office of Extramural Research (OER) webmaster contact (FBOWebmaster@OD.NIH.GOV).
Overall, the opportunity was essentially a call for mechanistic, function-focused lung disease genetics: take GWAS-implicated genes and variants and use well-integrated experimental and analytical approaches to show how they drive disease-relevant biology, creating a clearer path from genetic discovery to therapeutic or diagnostic insight.
Frequently Asked Questions (FAQs)
What is the name of this NIH/NHLBI grant opportunity?
The opportunity is titled "Getting from Genes to Function in Lung Disease, NHLBI (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-11-011.
Which NIH institute administers this opportunity?
The administering NIH institute is the National Heart, Lung, and Blood Institute (NHLBI).
What type of grant mechanism does this program use?
This opportunity uses the NIH R01 Research Project Grant mechanism.
What is the main purpose of this FOA?
The main purpose is to move lung disease genetics beyond statistical association and into biological understanding by supporting projects that determine what GWAS-implicated genes and variants actually do in the context of lung disease.
What kinds of research projects were this FOA trying to encourage?
The FOA encouraged mechanistic, function-focused studies that characterize the function of identified genes and variants and define their pathobiological roles in lung disease, including how variants affect gene expression or protein function, which molecular pathways are altered, what happens in relevant lung cell types, and how these changes contribute to disease initiation, progression, or severity.
Is this FOA aimed at discovering new genetic associations?
No. The emphasis was not on finding new associations. It was focused on taking existing implicated gene(s) and variants from GWAS or other human genetic approaches and generating actionable functional knowledge about how they drive disease biology.
What types of genetic evidence were expected as a starting point for applications?
Applications were expected to start from gene(s) and specific genetic variants already implicated in lung diseases through genome-wide association studies (GWAS) or other human genetic approaches.
What does "getting from genes to function" mean in the context of this program?
It means bridging the gap between a statistical signal in human genetic data (such as a GWAS locus) and a clear, experimentally supported mechanism, for example identifying a causal variant, linking it to a target gene, showing how it changes cellular behavior in relevant lung cell types, and connecting that change to measurable disease-related phenotypes.
Were cross-disciplinary or integrated approaches encouraged?
Yes. The FOA explicitly encouraged integrated, cross-disciplinary strategies combining methods and expertise across areas such as human genetics, molecular and cellular biology, physiology, bioinformatics, systems biology, and disease modeling.
What is the activity category for this grant opportunity?
The activity category listed for the opportunity was health research.
What is the CFDA number associated with this opportunity?
The relevant CFDA listing is 93.838 (Lung Diseases Research).
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. and non-U.S. organizations, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses, as listed), and government entities at the city, county, state, and special district levels.
Were specific institution types (such as HBCUs or Tribal colleges) included as eligible applicants?
Yes. The FOA explicitly included institutions and communities commonly named in federal eligibility language, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, Native American tribal governments (federally recognized and other than federally recognized), regional organizations, and U.S. territories or possessions.
Could non-U.S. (foreign) organizations apply?
Yes. Foreign (non-U.S.) entities were listed as eligible.
When was this FOA posted?
The FOA was posted on October 25, 2010.
What was the application closing date?
The original and current closing date listed was May 7, 2011.
Is this opportunity still open?
No. The FOA was archived on June 7, 2011, and the closing date was May 7, 2011.
Where can applicants find the full FOA announcement?
The full announcement was available on the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-11-011.html.
Who should be contacted if there are access issues with the FOA link?
For access issues or link problems, the notice directed applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What kinds of outcomes or insights was this program trying to produce?
The FOA aimed to produce rigorous, mechanistic insight into lung disease biology by translating genetic findings into functional understanding, helping clarify how genetic variation drives disease-relevant pathways, cellular effects, and phenotypes, with a clearer path toward therapeutic or diagnostic insight.
What would a strong application generally try to connect, according to the FOA description?
Strong applications would typically connect multiple levels of evidence, for example linking a GWAS locus to a causal variant, to a target gene, to a specific cellular mechanism in the lung, and finally to measurable disease-related phenotypes.
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