Opportunity Information: Apply for PAR 16 052
Apply for PAR 16 052
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.279, 93.313, 93.321, 93.393, 93.394, 93.395, 93.396, 93.399, 93.867, 93.989,.
- This funding opportunity was created on Dec 09, 2015 and posted on Dec 09, 2015.
- Applicants must submit their applications by Feb 22, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $125,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21) funding opportunity (PAR-16-052) is an NIH grant program designed to support early-stage, exploratory work focused on noncommunicable diseases (NCDs) and injury in low- and middle-income countries (LMICs). The main purpose is to fund the planning, design, and initial pilot studies that can spark larger, longer-term research programs. The emphasis is on projects that are locally relevant in the LMIC setting and that can act as catalytic starting points for stronger research pipelines, practical interventions, and sustainable in-country research capacity.
This announcement encourages research that looks across multiple NCDs and shared risk factors, reflecting how chronic diseases often cluster and how common exposures (such as tobacco use, unhealthy diets, physical inactivity, alcohol use, environmental exposures, and social determinants) can drive several conditions at once. It also explicitly encourages work that examines NCDs as comorbidities alongside infectious diseases, including HIV/AIDS. In other words, proposals are welcome that explore the real-world overlap between chronic conditions and infectious disease burdens, such as how diabetes or cardiovascular disease affects outcomes in people living with HIV, or how chronic disease care can be integrated into existing infectious disease platforms.
A core feature of the opportunity is international collaboration structured around LMIC institutions. Researchers based in the United States or in upper-middle-income countries (UMICs) are eligible to partner with scientists and institutions in LMICs, using the World Bank country income classifications as the formal reference point for eligibility. The intent is not only to generate preliminary findings, but also to help position LMIC investigators and institutions for sustained leadership in future research efforts, including the development of diagnostics, prevention strategies, treatments, and implementation approaches that fit local health systems and population needs.
The R21 mechanism signals that this is exploratory funding rather than support for large, mature trials or long multi-site programs. The expectation is that funded pilot activities will generate proof-of-concept data, refine methods, test feasibility, build partnerships, and clarify research questions so teams can move toward more comprehensive follow-on studies. The announcement also notes that projects may contribute to longer-term infrastructure beyond a single study, such as creating a base for research networking, strengthening evidence that can inform policy, and improving the ability of local systems to translate findings into practice.
The scope is specifically limited with respect to certain topic areas. Applications primarily focused on the brain, nervous system disorders, mental health, or substance abuse are directed to a separate companion announcement (PAR-14-331) and are considered inappropriate for this FOA. This means applicants working in those domains need to use the designated companion pathway rather than submitting under PAR-16-052.
Administratively, the opportunity is listed as a discretionary grant under HHS/NIH, with activity categories spanning education and health, and it references multiple CFDA numbers (93.213, 93.279, 93.313, 93.321, 93.393, 93.394, 93.395, 93.396, 93.399, 93.867, 93.989), reflecting NIH’s multi-institute involvement. The eligible applicant types are broad and include many U.S.-based organizational categories (such as public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations, small businesses, and various government entities, including tribal governments and organizations). The listing includes an award ceiling of $125,000 and shows the closing date as February 22, 2017, with an original posting date of December 9, 2015, indicating this particular notice reflects a past submission cycle even though it remains a useful reference for understanding the program’s aims and structure.
FAQs: Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21) (PAR-16-052)
What is PAR-16-052?
PAR-16-052 is an NIH funding opportunity announcement for an R21 grant titled "Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21)." It supports exploratory research focused on noncommunicable diseases (NCDs) and injury in low- and middle-income countries (LMICs).
What is the main purpose of this grant program?
The program is designed to fund early-stage, exploratory work such as planning, study design, and initial pilot studies. The goal is to generate proof-of-concept findings and feasibility evidence that can lead to larger, longer-term research programs.
What kinds of research activities does the R21 mechanism support under this opportunity?
This opportunity emphasizes pilot and exploratory activities, including refining research methods, testing feasibility, building partnerships, and clarifying research questions. It is not positioned as support for large, mature clinical trials or long multi-site programs.
What health topics are in scope for PAR-16-052?
The scope centers on noncommunicable diseases and injury across the lifespan in LMIC settings, especially work that is locally relevant and can serve as a catalytic starting point for stronger research pipelines and practical interventions.
Does the announcement encourage work across multiple NCDs and shared risk factors?
Yes. It encourages research that looks across multiple NCDs and shared risk factors, reflecting how chronic diseases often cluster and how common exposures can drive multiple conditions at once.
Which shared risk factors are specifically mentioned?
The announcement cites shared exposures and determinants such as tobacco use, unhealthy diets, physical inactivity, alcohol use, environmental exposures, and social determinants.
Are projects encouraged to study NCDs alongside infectious diseases?
Yes. The opportunity explicitly encourages work examining NCDs as comorbidities alongside infectious diseases, including HIV/AIDS, and welcomes research on real-world overlap between chronic and infectious disease burdens.
What is an example of the kind of NCD-infectious disease overlap this FOA is aiming for?
Examples described include exploring how diabetes or cardiovascular disease affects outcomes in people living with HIV, or studying how chronic disease care could be integrated into existing infectious disease platforms.
Why does the program emphasize locally relevant research in LMICs?
The stated intent is for projects to fit local LMIC health systems and population needs, act as catalytic starting points for sustainable research capacity, and help create stronger pipelines for interventions and implementation approaches in-country.
Who is expected to lead or anchor the international collaboration?
International collaboration is described as being structured around LMIC institutions, with an intent to position LMIC investigators and institutions for sustained leadership in future research efforts.
Can U.S.-based researchers participate?
Yes. U.S.-based researchers are eligible to partner with scientists and institutions in LMICs as part of the collaboration described in the announcement.
Can researchers or institutions in upper-middle-income countries (UMICs) participate?
Yes. The announcement states that researchers based in upper-middle-income countries (UMICs) are eligible to partner with scientists and institutions in LMICs.
How does the program define LMIC eligibility?
Country income classification is tied to the World Bank country income classifications, which are referenced as the formal basis for eligibility.
Is the goal only to generate pilot data, or is there a broader capacity-building aim?
In addition to preliminary findings, the announcement emphasizes strengthening sustainable in-country research capacity and positioning LMIC investigators and institutions for future leadership.
What longer-term outcomes does the FOA suggest pilot projects might support?
The announcement notes that projects may contribute to longer-term infrastructure beyond a single study, such as building a base for research networking, strengthening evidence that can inform policy, and improving the ability of local systems to translate findings into practice.
Is research primarily focused on brain or nervous system disorders appropriate for this FOA?
No. Applications primarily focused on the brain or nervous system disorders are directed to a separate companion announcement and are considered inappropriate for PAR-16-052.
Is mental health research appropriate for this FOA?
No. Applications primarily focused on mental health are directed to a separate companion announcement (PAR-14-331) and are considered inappropriate for this FOA.
Is substance abuse research appropriate for this FOA?
No. Applications primarily focused on substance abuse are directed to the companion announcement (PAR-14-331) and are considered inappropriate for PAR-16-052.
What is the companion announcement for brain, nervous system, mental health, or substance abuse-focused applications?
The announcement referenced for those topic areas is PAR-14-331.
Which federal agency administers this opportunity?
The opportunity is listed as a discretionary grant under HHS/NIH (the U.S. Department of Health and Human Services, National Institutes of Health).
What activity categories are associated with this listing?
The listing describes activity categories spanning education and health.
What CFDA numbers are referenced for this opportunity?
The listing references multiple CFDA numbers: 93.213, 93.279, 93.313, 93.321, 93.393, 93.394, 93.395, 93.396, 93.399, 93.867, and 93.989, reflecting NIH multi-institute involvement.
What types of organizations are eligible to apply?
Eligible applicant types are broad and include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations, small businesses, and various government entities, including tribal governments and tribal organizations.
Is this opportunity limited to nonprofit applicants?
No. The eligible applicants listed include for-profit organizations and small businesses in addition to nonprofit and academic organizations.
Is there an award ceiling listed for this opportunity?
Yes. The listing includes an award ceiling of $125,000.
What are the dates shown for this funding notice?
The listing shows an original posting date of December 9, 2015, and a closing date of February 22, 2017.
Is this notice associated with a past submission cycle?
Yes. The dates indicate the notice reflects a past submission cycle, even though it can still be used as a reference for understanding the program's aims and structure.
What is the overarching theme of the research encouraged by this FOA?
The overarching theme is exploratory, LMIC-relevant research on noncommunicable diseases and injury, including cross-cutting work on shared risk factors and the interaction of NCDs with infectious disease burdens, with a strong emphasis on collaboration anchored in LMIC institutions and building sustainable research capacity.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 16 052) also looked into and applied for these:
| Funding Opportunity |
|---|
| Integration of Infectious Diseases and Substance Abuse Intervention Services for Individuals Living with HIV (R01) Apply for RFA DA 16 011 Funding Number: RFA DA 16 011 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Innovative Questions in Symptom Science and Genomics (R21) Apply for PA 16 023 Funding Number: PA 16 023 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) Apply for PAR 16 059 Funding Number: PAR 16 059 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $450,000 |
| Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R01) Apply for PA 16 030 Funding Number: PA 16 030 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21) Apply for RFA CA 16 001 Funding Number: RFA CA 16 001 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R21) Apply for PA 16 029 Funding Number: PA 16 029 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Effects of Drugs of Abuse on Latent HIV Reservoirs in the CNS (R01) Apply for RFA DA 16 014 Funding Number: RFA DA 16 014 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| NCI Research Specialist Award (R50) Apply for PAR 16 025 Funding Number: PAR 16 025 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Drug Discovery For Nervous System Disorders (R01) Apply for PAR 16 041 Funding Number: PAR 16 041 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| HIV/AIDS High Priority Drug Abuse Research (R01) Apply for PAS 16 018 Funding Number: PAS 16 018 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Exploring Epigenomic or Non-Coding RNA Regulation in HIV/AIDS and Substance Abuse (R01) Apply for RFA DA 16 012 Funding Number: RFA DA 16 012 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Genomic Data Analysis Network: Visualization Genomic Data Center (U24) Apply for RFA CA 15 019 Funding Number: RFA CA 15 019 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $660,000 |
| The NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) Apply for RFA CA 16 005 Funding Number: RFA CA 16 005 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Behavioral and Integrative Treatment Development Program (R03) Apply for PA 16 074 Funding Number: PA 16 074 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $50,000 |
| Clinical Development of Minimally-Invasive Bioassays to Support Outpatient Clinical Trials of Therapeutics for Substance Use Disorders (R21) Apply for PA 16 075 Funding Number: PA 16 075 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Behavioral and Integrative Treatment Development Program (R34) Apply for PA 16 073 Funding Number: PA 16 073 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $225,000 |
| Clinical Development of Minimally-Invasive Bioassays to Support Outpatient Clinical Trials of Therapeutics for Substance Use Disorders (R01) Apply for PA 16 076 Funding Number: PA 16 076 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $500,000 |
| Behavioral Science Track Award for Rapid Transition (B/Start)(R03) Apply for PAR 16 071 Funding Number: PAR 16 071 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $75,000 |
| Behavioral and Integrative Treatment Development Program (R01) Apply for PA 16 072 Funding Number: PA 16 072 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20) Apply for PAR 16 084 Funding Number: PAR 16 084 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $275,000 |
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