Opportunity Information: Apply for PAR 14 264
Apply for PAR 14 264
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Global Omics Approaches Targeting Adverse Pregnancy and Neonatal Outcomes Utilizing Existing Cohorts (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jun 20, 2014 and posted on Jun 20, 2014.
- Applicants must submit their applications by Oct 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Native American tribal governments (Federally recognized) Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Public and State controlled institutions of higher education For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
PAR 14-264, titled "Global Omics Approaches Targeting Adverse Pregnancy and Neonatal Outcomes Utilizing Existing Cohorts (R01)," is an NIH discretionary grant opportunity designed to push forward research on major pregnancy and newborn health problems by applying modern "omics" technologies to data and biospecimens that already exist in established cohorts. The core idea is to take advantage of well-characterized participant groups that have already been recruited and followed, then use state-of-the-science laboratory and computational methods to uncover biological signals, pathways, and risk patterns that contribute to adverse pregnancy and neonatal outcomes. Rather than funding the creation of entirely new cohorts from scratch, the announcement centers on extracting new value from existing resources, which can speed discovery and improve efficiency.
The scientific emphasis is on high-dimensional, global profiling approaches such as genomics, epigenomics, proteomics, and metabolomics, paired with strong bioinformatics and other advanced analytic tools. In practice, this means applicants are expected to generate or analyze large-scale molecular datasets and integrate them with clinical, demographic, and other cohort information in order to better understand the biology of pregnancy complications and poor neonatal outcomes. The FOA encourages approaches that can identify biomarkers, molecular mechanisms, and potentially modifiable pathways, especially when these insights can improve risk prediction, refine disease classification, or clarify how maternal and fetal factors interact across pregnancy and early life. The word "global" in the title signals that the program is open to research that is international in scope and that foreign institutions and non-U.S. components are explicitly eligible, reflecting an interest in leveraging cohorts worldwide.
From an administrative standpoint, this opportunity uses the NIH R01 research project grant mechanism, supporting investigator-driven projects that are typically multi-year and hypothesis-driven or discovery-enabled, depending on the study design. It falls under the Health category and is associated with CFDA number 93.865, which corresponds to the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) extramural research portfolio. The FOA states there is no cost sharing or matching requirement, which means applicants are not required to provide institutional matching funds as a condition of the award.
Eligibility is broad and includes many types of U.S. organizations and governments, as well as non-U.S. entities. Eligible applicants listed include state, county, city/township, special district governments, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education), small businesses, for-profit organizations (other than small businesses), independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes a range of institution types and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies. Importantly, foreign organizations and foreign institutions are eligible to apply, and foreign components (as NIH defines them) are allowed, which supports the "global" scope and encourages the use of international cohort resources.
Key dates in the source information show the FOA was posted and created on June 20, 2014, with an original and final closing date of October 7, 2016, and an archive date of November 7, 2016. In other words, this particular announcement is historical and is no longer open for new submissions, but it still provides a clear template for the kinds of projects NIH sought to stimulate at the time: omics-based, computationally intensive, cohort-enabled studies focused on adverse pregnancy and neonatal outcomes.
The main practical takeaway is that PAR 14-264 aimed to fund R01 projects that can use existing pregnancy and birth-related cohorts to generate and integrate omics datasets, apply rigorous bioinformatics, and produce insights with real relevance to maternal and newborn health. The full announcement was made available through the NIH Grants Guide (the link provided in the source), and the NIH Office of Extramural Research (OER) webmaster contacts were listed for technical issues accessing the announcement or links.
Frequently Asked Questions (FAQs)
What is PAR 14-264?
PAR 14-264 is an NIH discretionary funding opportunity announcement titled "Global Omics Approaches Targeting Adverse Pregnancy and Neonatal Outcomes Utilizing Existing Cohorts (R01)." It was designed to support research that applies modern omics technologies to data and biospecimens already collected in established pregnancy and birth-related cohorts.
What is the main goal of this opportunity?
The goal is to advance understanding of major pregnancy and newborn health problems by using high-dimensional, global omics profiling and advanced analytics to identify biological signals, pathways, biomarkers, and risk patterns linked to adverse pregnancy and neonatal outcomes.
What does "utilizing existing cohorts" mean in this FOA?
It means the research is expected to leverage well-characterized participant groups that have already been recruited and followed, along with the cohorts' existing clinical, demographic, and related information and biospecimens. The FOA emphasizes extracting new scientific value from existing resources rather than creating entirely new cohorts from scratch.
Why does the FOA emphasize existing cohorts instead of building new ones?
Based on the description provided, the intent is to speed discovery and improve efficiency by using already-established cohorts and previously collected biospecimens and data, then applying state-of-the-science laboratory and computational methods to uncover new insights.
What types of "omics" approaches are encouraged?
The FOA highlights high-dimensional, global profiling approaches, including genomics, epigenomics, proteomics, and metabolomics, paired with strong bioinformatics and other advanced analytic tools.
What is meant by "global" in the FOA title?
"Global" signals that the program is open to research international in scope. Foreign institutions and non-U.S. components are explicitly eligible, reflecting an interest in leveraging cohorts worldwide.
What kinds of outcomes is the research meant to address?
The scientific focus is on adverse pregnancy outcomes and adverse neonatal outcomes, with an emphasis on identifying mechanisms and risk patterns that contribute to major pregnancy and newborn health problems.
What kinds of research outputs does the FOA encourage?
The FOA encourages work that can identify biomarkers, clarify molecular mechanisms, and uncover potentially modifiable pathways, particularly when the findings can improve risk prediction, refine disease classification, or clarify interactions between maternal and fetal factors across pregnancy and early life.
What grant mechanism is used for PAR 14-264?
This opportunity uses the NIH R01 research project grant mechanism, supporting investigator-driven research projects that are typically multi-year and may be hypothesis-driven or discovery-enabled depending on study design.
Which NIH area or category does this opportunity fall under?
It falls under the Health category and is associated with CFDA number 93.865, corresponding to the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) extramural research portfolio.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to provide institutional matching funds as a condition of the award.
Who is eligible to apply?
Eligibility is broad and includes many U.S. organizations and governments as well as non-U.S. entities. Eligible applicants listed include state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); small businesses; for-profit organizations (other than small businesses); independent school districts; and public housing authorities/Indian housing authorities.
Are specific institution types and communities explicitly included?
Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also notes faith-based or community-based organizations and eligible federal agencies.
Are foreign organizations eligible?
Yes. Foreign organizations and foreign institutions are eligible to apply, and foreign components (as NIH defines them) are allowed, supporting the FOA's international scope.
What kind of data integration does the FOA expect?
Applicants are expected to generate or analyze large-scale molecular datasets and integrate them with clinical, demographic, and other cohort information, using rigorous bioinformatics and advanced analytic methods.
Is this funding opportunity still open?
No. The key dates provided indicate the FOA was posted and created on June 20, 2014, with an original and final closing date of October 7, 2016, and an archive date of November 7, 2016. This means it is historical and no longer open for new submissions.
Where was the original announcement published?
The full announcement was made available through the NIH Grants Guide (per the source information provided).
Who was listed for technical help with accessing the announcement or links?
The NIH Office of Extramural Research (OER) webmaster contacts were listed for technical issues accessing the announcement or links.
What is the practical takeaway from PAR 14-264?
The practical takeaway is that PAR 14-264 aimed to fund R01 projects that use existing pregnancy and birth-related cohorts to generate and integrate omics datasets, apply advanced bioinformatics, and produce findings relevant to improving understanding of maternal and newborn health problems.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 14 264) also looked into and applied for these:
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| Peripheral Blood Biomarkers of Chronic Traumatic Brain Injury in Human Subjects SBIR Direct Phase II (R44) Apply for RFA HD 15 012 Funding Number: RFA HD 15 012 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $750,000 |
| Innovative Therapies and Tools for Screenable Disorders in Newborns (R21) Apply for PAR 14 269 Funding Number: PAR 14 269 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Innovative Therapies and Tools for Screenable Disorders in Newborns (R03) Apply for PAR 14 271 Funding Number: PAR 14 271 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| Pharmacogenetics, Pharmacoepigenetics and Personalized Medicine in Children (R01) Apply for PAR 14 274 Funding Number: PAR 14 274 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R01) Apply for PAR 14 272 Funding Number: PAR 14 272 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R21) Apply for PAR 14 273 Funding Number: PAR 14 273 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Pediatric Cardiac Genomics Consortium (UM1) Apply for RFA HL 15 012 Funding Number: RFA HL 15 012 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $269,000 |
| In vivo Methods for Assessing Placental Development and Function (SBIR) R43/R44 Apply for RFA HD 15 018 Funding Number: RFA HD 15 018 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| In vivo Methods for Assessing Placental Development and Function (STTR) R41/R42 Apply for RFA HD 15 019 Funding Number: RFA HD 15 019 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,000,000 |
| Obstetric Fetal Pharmacology Research Centers (OPRC) (U54) Apply for RFA HD 14 013 Funding Number: RFA HD 14 013 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $4,800,000 |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R01) Apply for PA 14 312 Funding Number: PA 14 312 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R21) Apply for PA 14 311 Funding Number: PA 14 311 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R03) Apply for PA 14 313 Funding Number: PA 14 313 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| NICHD Consortium for Research on Pediatric Trauma and Injury Prevention (R24) Apply for PAR 14 324 Funding Number: PAR 14 324 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $750,000 |
| Improving Health through Rehabilitation Robotic Technology (R43/R44) Apply for RFA HD 15 001 Funding Number: RFA HD 15 001 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41) Apply for RFA HD 15 005 Funding Number: RFA HD 15 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R43) Apply for RFA HD 15 006 Funding Number: RFA HD 15 006 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54) Apply for RFA AR 15 002 Funding Number: RFA AR 15 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,000,000 |
| Biomarkers of Alzheimers Disease in Down Syndrome (R01) Apply for RFA AG 15 011 Funding Number: RFA AG 15 011 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,500,000 |
| Biomedical/Biobehavioral Research Administration Development (BRAD) Award (G11) Apply for PAR 14 333 Funding Number: PAR 14 333 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $85,000 |
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