Opportunity Information: Apply for RFA AA 10 007
Apply for RFA AA 10 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Gut Liver Brain Interactions in Alcohol Induced Pathogenesis (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 14, 2009 and posted on Dec 14, 2009.
- Applicants must submit their applications by Apr 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) Private institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Special district governments Small businesses County governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This grant opportunity, titled "Gut Liver Brain Interactions in Alcohol Induced Pathogenesis (R01)" (Funding Opportunity Number RFA-AA-10-007), is a discretionary research grant from the National Institutes of Health (NIH) through the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The core aim is to push forward innovative, mechanistic research on how alcohol interferes with normal communication among the gut, liver, and brain, and how those disrupted signaling pathways and feedback loops drive the onset, worsening, or persistence of alcohol-associated diseases. The scientific emphasis is on understanding alcohol's effects not just within a single organ, but across a connected system where changes in one site (for example, altered gut barrier function or microbiome-related signals) can influence liver inflammation and metabolism, and in turn affect brain function and systemic physiology. By focusing on these organ-to-organ interactions, the FOA is trying to encourage work that explains how alcohol undermines normal homeostasis at multiple levels, from cellular and molecular events to whole-body consequences, ultimately leading to tissue injury.
The funding mechanism is the NIH Research Project Grant (R01), which is typically used for more mature, hypothesis-driven projects with a clear plan, strong preliminary rationale, and a scope that can support multi-year investigation. This announcement is paired with a companion FOA of the same scientific scope that uses the R21 mechanism (RFA-AA-10-008), which generally supports earlier-stage, exploratory or high-risk ideas. In practical terms, the R01 version is oriented toward larger, more developed projects, while the parallel R21 option provides a pathway for smaller, more exploratory studies, both aimed at the same broad problem of gut-liver-brain axis disruption in alcohol-related pathology.
For funding, NIAAA projected a combined total of about $2,000,000 in fiscal year 2010 across this R01 FOA and the companion R21 FOA, with an expectation of making up to 8 awards in total. The award ceiling listed is $500,000. As with most NIH opportunities, awards depend on the availability of appropriated funds and on whether enough highly meritorious applications are received. The opportunity does not require cost sharing or matching.
Eligibility is broad and includes a wide range of U.S.-based and non-U.S. entities. Eligible applicants span public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses), small businesses, state and local governments (including county, city/township, special district governments), public housing authorities/Indian housing authorities, and tribal entities (federally recognized tribal governments as well as other tribal organizations). The eligibility language also highlights inclusion of organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign (non-U.S.) organizations.
Key administrative details include a posted date and creation date of December 14, 2009, with an original and current closing date of April 20, 2010, and an archive date of May 21, 2010. The opportunity falls under the Health activity category, with CFDA number 93.273 (Alcohol Research Programs). Additional information and the full announcement were provided through the NIH grants guide website link included in the source. For technical access issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Gut Liver Brain Interactions in Alcohol Induced Pathogenesis (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AA-10-007.
Which agency is offering this funding?
This is a discretionary research grant offered through the National Institutes of Health (NIH), specifically via the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main purpose of the grant?
The core aim is to advance innovative, mechanistic research on how alcohol disrupts normal communication among the gut, liver, and brain, and how those disrupted signaling pathways and feedback loops contribute to the onset, progression, or persistence of alcohol-associated diseases.
What scientific focus does the FOA emphasize?
The FOA emphasizes understanding alcohol's effects across a connected gut-liver-brain system rather than within a single organ. It highlights organ-to-organ interactions where changes in one site (such as altered gut barrier function or microbiome-related signals) can influence liver inflammation and metabolism, which can then affect brain function and broader systemic physiology.
What types of research questions fit this opportunity?
Research that explains how alcohol undermines normal homeostasis at multiple levels is a fit, including work spanning cellular and molecular events through to whole-body consequences that lead to tissue injury, with a specific emphasis on cross-organ signaling and feedback loops among the gut, liver, and brain.
What funding mechanism is used for this announcement?
This FOA uses the NIH Research Project Grant (R01) mechanism.
What does the R01 mechanism imply about project scope?
The R01 mechanism is typically used for more mature, hypothesis-driven projects with a clear plan, strong preliminary rationale, and a scope suitable for multi-year investigation.
Is there a related or companion funding opportunity?
Yes. This R01 FOA is paired with a companion FOA using the R21 mechanism: RFA-AA-10-008. Both share the same broad scientific scope focused on gut-liver-brain axis disruption in alcohol-related pathology.
How does the companion R21 FOA differ from this R01 FOA?
Based on the description provided, the R01 version is oriented toward larger, more developed projects, while the parallel R21 option supports earlier-stage, exploratory, or higher-risk ideas, with a smaller scope.
How much funding is available under this opportunity?
NIAAA projected a combined total of about $2,000,000 in fiscal year 2010 across this R01 FOA and the companion R21 FOA.
How many awards are expected?
The expectation stated is up to 8 awards in total across the R01 FOA (RFA-AA-10-007) and the companion R21 FOA (RFA-AA-10-008).
What is the award ceiling listed for this opportunity?
The award ceiling listed is $500,000.
Are awards guaranteed if an application is submitted?
No. As stated, awards depend on the availability of appropriated funds and on whether enough highly meritorious applications are received.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
Who is eligible to apply?
Eligibility is broad and includes a wide range of U.S.-based and non-U.S. entities, spanning public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses), small businesses, and multiple types of government and tribal entities.
Are higher education institutions eligible?
Yes. Public and private institutions of higher education are included as eligible applicants.
Are nonprofit organizations eligible?
Yes. Both 501(c)(3) and non-501(c)(3) nonprofit organizations are listed as eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, and the eligibility list also mentions small businesses; it also notes for-profit organizations other than small businesses in the eligible applicant types.
Are small businesses eligible?
Yes. Small businesses are included among eligible applicants.
Are state and local government entities eligible?
Yes. State and local governments are included, including county, city/township, and special district governments.
Are tribal entities eligible?
Yes. Federally recognized tribal governments and other tribal organizations are included in the eligibility language.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are specifically highlighted in the eligibility language.
Are foreign (non-U.S.) organizations eligible?
Yes. Foreign (non-U.S.) organizations are explicitly included as eligible applicants.
Does the FOA encourage applications from specific types of institutions or organizations?
The eligibility language highlights inclusion of organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among others.
What is the activity category for this opportunity?
The opportunity is listed under the Health activity category.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.273 (Alcohol Research Programs).
When was this opportunity posted?
The posted date is December 14, 2009.
What is the creation date for the opportunity listing?
The creation date is December 14, 2009.
What was the application closing date?
The original and current closing date listed is April 20, 2010.
When was the opportunity archived?
The archive date listed is May 21, 2010.
Where was additional information provided?
Additional information and the full announcement were provided through the NIH grants guide website link included in the source.
Who is the contact for technical access issues?
The contact listed for technical access issues is the NIH Office of Extramural Research (OER) webmaster.
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