Opportunity Information: Apply for RFA AA 10 008
Apply for RFA AA 10 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Gut Liver Brain Interactions in Alcohol Induced Pathogenesis (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 14, 2009 and posted on Dec 14, 2009.
- Applicants must submit their applications by Apr 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses City or township governments For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) State governments Public housing authorities/Indian housing authorities County governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Gut Liver Brain Interactions in Alcohol Induced Pathogenesis (R21) funding opportunity (RFA-AA-10-008) is a National Institutes of Health grant announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) aimed at sparking early-stage, high-impact research on how alcohol alters communication pathways between the gut, liver, and brain. The central scientific focus is on two connected questions: first, what specific ways alcohol disrupts normal physiological signaling and coordination among these organs, and second, how those disruptions help drive the onset, progression, or worsening of alcohol-associated diseases. The broader intent is to move beyond studying single-organ damage in isolation and instead build a clearer picture of alcohol-related disease as a systems problem, where changes in one organ can trigger or amplify dysfunction in others.
This FOA uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is typically designed to support innovative, proof-of-concept projects, pilot studies, or new directions that may not yet have extensive preliminary data. In practice, that means applicants are expected to propose creative and potentially transformative ideas that can uncover new biological mechanisms or open up new research avenues related to gut-liver-brain axis biology in the context of alcohol exposure. The announcement also notes that it runs in parallel with a companion opportunity of the same scientific scope under an R01 mechanism (RFA-AA-10-007). The R01 track is generally more suited to mature, fully developed projects, while the R21 is positioned for exploratory work that can later scale into larger studies.
From a funding standpoint, NIAAA planned a combined commitment of approximately $2,000,000 in fiscal year 2010 across both this R21 FOA and the companion R01 FOA, with an expectation of making up to eight total awards. Individual R21 applications under this announcement had an award ceiling listed at $200,000. As with most federal research announcements, actual awards were contingent on the availability of appropriated funds and on receiving a sufficient number of highly competitive, scientifically meritorious proposals.
Eligibility was broad and inclusive, covering a wide range of applicant types. Eligible entities included public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, for-profit organizations (including those other than small businesses), and multiple levels of government such as city or township governments, counties, states, special district governments, and certain housing authorities. The FOA also explicitly included tribal governments (federally recognized and other than federally recognized), tribal colleges and universities, and other mission-driven institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. It further allowed non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions. No cost sharing or matching was required, which reduces barriers for applicants who may not have access to non-federal funds.
Key administrative details are straightforward: the opportunity category is discretionary, the instrument is a grant, and the activity category is health, with CFDA number 93.273 (Alcohol Research Programs). The FOA was posted on December 14, 2009, with an application closing date of April 20, 2010, and it was archived on May 21, 2010. The full announcement was hosted through NIH, and applicants having trouble accessing it were directed to contact the NIH Office of Extramural Research (OER) webmaster for technical assistance.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is the NIH funding opportunity titled Gut Liver Brain Interactions in Alcohol Induced Pathogenesis (R21), with FOA number RFA-AA-10-008. It was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the purpose of RFA-AA-10-008?
The purpose is to stimulate early-stage, high-impact research on how alcohol changes communication pathways between the gut, liver, and brain, and how those changes contribute to the onset, progression, or worsening of alcohol-associated diseases.
What scientific questions does this FOA emphasize?
The FOA highlights two connected scientific questions: (1) the specific ways alcohol disrupts normal physiological signaling and coordination among the gut, liver, and brain, and (2) how those disruptions help drive alcohol-associated disease development and severity.
What makes the scientific approach distinctive in this announcement?
The announcement encourages a systems-level view of alcohol-related disease. Instead of studying single-organ injury in isolation, it prioritizes research that clarifies how dysfunction in one organ can trigger or amplify dysfunction in others across the gut-liver-brain axis.
What grant mechanism does this FOA use?
This FOA uses the NIH Exploratory/Developmental Research Grant (R21) mechanism.
What type of projects is the R21 mechanism intended to support here?
The R21 mechanism is positioned to support innovative, proof-of-concept projects, pilot studies, or new research directions that may not yet have extensive preliminary data, as long as the ideas are creative and could open new avenues in gut-liver-brain axis biology related to alcohol exposure.
Is there a companion funding opportunity related to this one?
Yes. This R21 FOA runs in parallel with a companion opportunity under an R01 mechanism: RFA-AA-10-007. Both share the same scientific scope, but the R01 track is generally aimed at more mature, fully developed projects.
How much funding was planned for this FOA?
NIAAA planned a combined commitment of approximately $2,000,000 in fiscal year 2010 across this R21 FOA and the companion R01 FOA.
How many awards were expected?
Across both the R21 and the companion R01 FOAs, NIAAA expected to make up to eight total awards, contingent on available funds and the receipt of sufficiently strong applications.
What is the maximum award amount for an individual R21 application under this announcement?
The R21 award ceiling listed in the announcement was $200,000 per application.
Are awards guaranteed if an application is submitted?
No. As stated in the announcement, awards were contingent on the availability of appropriated funds and on receiving a sufficient number of highly competitive, scientifically meritorious proposals.
Who is eligible to apply?
Eligibility is broad and includes many types of organizations, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses, for-profit organizations (including those other than small businesses), and multiple levels of government.
Which government entities are included as eligible applicants?
The FOA includes eligibility for city or township governments, county governments, state governments, special district governments, and certain housing authorities.
Are tribal organizations eligible?
Yes. The FOA explicitly includes tribal governments (federally recognized and those other than federally recognized) and tribal colleges and universities.
Are minority-serving or mission-driven institutions included?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Are foreign organizations allowed to apply?
Yes. The FOA allows non-U.S. entities (foreign organizations), as well as regional organizations and U.S. territories or possessions.
Is cost sharing or matching required?
No. The announcement states that no cost sharing or matching is required.
What is the opportunity category and instrument type?
The opportunity category is discretionary. The instrument is a grant.
What is the activity category and CFDA number?
The activity category is health. The CFDA number is 93.273 (Alcohol Research Programs).
When was the FOA posted, and what were the key dates?
The FOA was posted on December 14, 2009. The application closing date was April 20, 2010. The FOA was archived on May 21, 2010.
Where was the full announcement hosted?
The full announcement was hosted through NIH.
Who should be contacted for technical trouble accessing the announcement?
Applicants having trouble accessing the full announcement were directed to contact the NIH Office of Extramural Research (OER) webmaster for technical assistance.
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