Opportunity Information: Apply for RFA AI 14 045
Apply for RFA AI 14 045
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Hepatitis C Cooperative Research Centers Immunity to HCV Infection (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Oct 8, 2014 and posted on Oct 8, 2014.
- Applicants must submit their applications by Feb 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Hepatitis C Cooperative Research Centers: Immunity to HCV Infection (U19) funding opportunity (RFA-AI-14-045) was a National Institutes of Health (NIH) discretionary grant program that used the cooperative agreement mechanism to support coordinated, multi-project research centers focused on how the human host immune system responds to Hepatitis C Virus (HCV). The central aim was to generate a clearer, evidence-based definition of the immune requirements needed for two closely related outcomes: first, protection against becoming infected with HCV in the first place, and second, successful clearance of infection after exposure. In practice, this kind of FOA is designed to move beyond isolated projects by encouraging integrated teams to work together as “HepC Centers,†aligning research approaches, sharing resources and data, and collectively producing insights that can inform vaccines, immunotherapies, and other prevention or cure-related strategies.
This opportunity was issued as a U19 cooperative agreement, which generally means NIH anticipated having substantial scientific and/or programmatic involvement during the award period compared with a standard research project grant. The “cooperative research center†framing signals an emphasis on collaboration and coordination across multiple components, such as complementary research projects and shared core resources, with the expectation that the resulting program will function as a unified center rather than a set of unrelated studies. The scientific focus was specifically the immunology of HCV infection, targeting the types of immune responses, immune correlates, and immune mechanisms that distinguish people who resist infection or rapidly control it from those who develop persistent, chronic infection.
The FOA projected an expected total of about four awards, with an estimated total funding level of $3,000,000 and an award ceiling of $500,000. It did not require cost sharing or matching. The opportunity fell under NIH’s health-related research mission and was associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting its placement within infectious disease and immunology research priorities.
Eligibility was broad and included many types of domestic U.S. applicant organizations across public and private sectors. Eligible applicants included state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status (with the usual NIH distinctions about institutions of higher education); small businesses; and other for-profit organizations that are not small businesses. The FOA also explicitly included a range of institution types often highlighted in federal funding opportunities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Non-U.S. entities (foreign organizations and foreign institutions) were not eligible to apply as applicant organizations, and non-U.S. components of U.S. organizations were not eligible; however, foreign components as defined in NIH policy were allowed, which typically means discrete foreign collaborations could be included when scientifically justified while keeping the primary applicant and award administration within the U.S.
From a timeline standpoint, the FOA was posted and created on October 8, 2014, with an original and current closing date of February 3, 2015, and it was archived on March 6, 2015. NIH provided an additional information link to the full announcement text on the NIH grants guide website, and contact support was routed through the NIH Office of Extramural Research (OER) webmaster for access or linking issues. Overall, the grant opportunity was structured to build a small number of well-coordinated research centers capable of producing actionable, immunology-focused knowledge about what it takes to prevent HCV infection and what immune pathways and responses are associated with clearing the virus once infection occurs.
Frequently Asked Questions (FAQs)
What is the Hepatitis C Cooperative Research Centers: Immunity to HCV Infection (U19) opportunity?
It was a National Institutes of Health (NIH) discretionary funding opportunity (RFA-AI-14-045) that supported coordinated, multi-project cooperative research centers focused on human immune responses to Hepatitis C Virus (HCV). The program was designed to operate as integrated “HepC Centers†rather than isolated, unrelated projects.
What was the main scientific goal of this funding opportunity?
The central aim was to produce a clearer, evidence-based definition of the immune requirements for two related outcomes: (1) protection against acquiring HCV infection and (2) successful clearance of infection after exposure. The research emphasis was on HCV immunology, including immune responses, immune correlates, and immune mechanisms linked to resistance, rapid control, or progression to chronic infection.
What type of NIH award mechanism was used?
This opportunity used the U19 cooperative agreement mechanism. A cooperative agreement generally indicates NIH expected substantial scientific and/or programmatic involvement during the award period compared with a standard research project grant.
What does “cooperative research center†mean in this context?
It indicates an expectation of collaboration and coordination across multiple components, such as complementary research projects and shared core resources. The intent was for the funded program to function as a unified center with aligned approaches, shared resources and data, and coordinated output.
How many awards were expected under this FOA?
The FOA projected an expected total of about four awards.
What was the estimated total funding level for the program?
The estimated total funding level was about $3,000,000.
What was the award ceiling mentioned in the opportunity?
The award ceiling was $500,000.
Was cost sharing or matching required?
No. The FOA did not require cost sharing or matching.
Which NIH mission area did this opportunity fall under?
It fell under NIH’s health-related research mission, focused on infectious disease and immunology research related to HCV infection.
What CFDA numbers were associated with this opportunity?
The opportunity was associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Who was eligible to apply?
Eligibility was broad and included many types of domestic U.S. applicant organizations across public and private sectors. Eligible applicants included:
- State, county, city/township, and special district governments
- Public housing authorities/Indian housing authorities
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits with or without 501(c)(3) status (with NIH distinctions regarding institutions of higher education)
- Small businesses
- Other for-profit organizations that are not small businesses
- Faith-based or community-based organizations
- Eligible federal agencies
Did the FOA specifically include institutions such as HBCUs or Tribal colleges?
Yes. The FOA explicitly included institution types often highlighted in federal funding opportunities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs).
Were non-U.S. (foreign) organizations eligible to apply as the applicant institution?
No. Non-U.S. entities (foreign organizations and foreign institutions) were not eligible to apply as applicant organizations.
Were non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations were not eligible under this opportunity.
Were any foreign collaborations allowed at all?
Yes, foreign components (as defined in NIH policy) were allowed. This typically means discrete foreign collaborations could be included when scientifically justified, while the primary applicant and award administration remained within the United States.
What kinds of outcomes or impacts was the program aiming to support?
The program was intended to generate coordinated, immunology-focused knowledge that could inform vaccines, immunotherapies, and other prevention or cure-related strategies by clarifying immune pathways and responses associated with preventing infection or clearing virus after exposure.
When was the funding opportunity posted?
The FOA was posted and created on October 8, 2014.
What was the application closing date?
The original and current closing date listed for the FOA was February 3, 2015.
Is this opportunity still active?
No. The FOA was archived on March 6, 2015.
Where could applicants find the full announcement text?
NIH provided an additional information link to the full announcement text on the NIH Grants Guide website.
Who was listed for help with access or linking issues?
Contact support for access or linking issues was routed through the NIH Office of Extramural Research (OER) webmaster.
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