Opportunity Information: Apply for RFA AI 15 025
Apply for RFA AI 15 025
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Hepatitis C Cooperative Research Centers Immunity to HCV Infection (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Apr 16, 2015 and posted on Apr 16, 2015.
- Applicants must submit their applications by Jun 24, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public housing authorities/Indian housing authorities Small businesses Special district governments Independent school districts Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) County governments State governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This grant opportunity, titled "Hepatitis C Cooperative Research Centers Immunity to HCV Infection (U19)," is a National Institutes of Health (NIH) funding announcement (RFA-AI-15-025) designed to support coordinated, center-based research focused on how the human immune system responds to Hepatitis C Virus (HCV) infection. The central aim is to clarify which immune responses are required to (a) prevent HCV infection in the first place and (b) successfully clear the virus after infection occurs. Rather than funding isolated projects, the announcement is built around establishing or supporting Hepatitis C Cooperative Research Centers (HepC Centers), meaning applicants are expected to propose collaborative, multi-project programs that work together under a shared scientific theme related to immunity and HCV.
The mechanism used is a cooperative agreement (U19), which signals a more hands-on partnership between NIH and the funded research teams than a standard research grant. In practice, this usually means NIH program staff will have substantial involvement in coordination, oversight, and alignment of activities across projects, with an emphasis on cooperation, shared goals, and integration across scientific components. The funding activity category is health, and it is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research, reflecting the immunology and infectious disease focus).
From a funding standpoint, the announcement listed an estimated total of about $3,000,000 in available funding, with an award ceiling of $500,000. There was no cost sharing or matching requirement, which means applicants were not required to contribute non-federal funds as a condition of receiving an award. The FOA was posted on April 16, 2015, and the application deadline was June 24, 2015 (with the opportunity later archived on July 25, 2015). While the dates indicate this specific announcement cycle has closed, the structure and intent are representative of NIH center-style efforts aimed at accelerating progress in understanding protective and curative immune responses relevant to vaccine development, immunotherapies, and better strategies to prevent chronic HCV infection.
Eligibility was broad and included many types of U.S.-based organizations: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for-profit entities (other than small businesses), and various government bodies such as state, county, city/township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and federally recognized Native American tribal governments. The announcement also explicitly included a range of mission-focused and serving-institution categories, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign institutions and non-U.S. components of U.S. organizations were not eligible to apply; however, foreign components as defined under NIH policy were allowed, which typically means a U.S. applicant could include certain foreign collaborations or activities if justified and permitted under NIH rules.
Overall, the opportunity was aimed at building integrated research centers capable of generating a clearer, evidence-based picture of what successful immunity to HCV looks like, both for preventing infection and for achieving viral clearance. By emphasizing cooperative, center-driven work under a U19 mechanism, NIH was signaling a preference for teams that can combine multiple complementary research projects, share resources and data, and work in a coordinated way to answer high-impact immunology questions that are difficult to solve through single-lab efforts. For full historical details and the official FOA text, NIH provided the announcement page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-025.html, and included contact support via the NIH Office of Extramural Research (OER) webmaster email for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Hepatitis C Cooperative Research Centers Immunity to HCV Infection (U19)."
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) funding announcement.
What is the funding announcement number (FOA/RFA)?
The announcement number is RFA-AI-15-025.
What is the main scientific purpose of this opportunity?
The central purpose is to support coordinated, center-based research focused on how the human immune system responds to Hepatitis C Virus (HCV) infection. The goal is to clarify which immune responses are required to (a) prevent HCV infection and (b) clear the virus after infection occurs.
What are the main research questions the program is trying to answer?
The program is designed to identify the immune responses associated with protection against acquiring HCV infection and the immune responses associated with successful viral clearance after infection.
Is this intended for single-project proposals or multi-project programs?
This announcement is built around establishing or supporting Hepatitis C Cooperative Research Centers (HepC Centers). Applicants are expected to propose collaborative, multi-project programs that work together under a shared scientific theme related to immunity and HCV, rather than isolated single projects.
What is meant by "Hepatitis C Cooperative Research Centers (HepC Centers)" in this context?
In this opportunity, HepC Centers refer to coordinated, center-style research programs made up of multiple complementary projects that are integrated under a shared theme related to immunity to HCV. The intent is to enable teams to share resources and data and to work in a coordinated way on questions that are difficult to solve through single-lab efforts.
What funding mechanism is being used?
The mechanism is a cooperative agreement (U19).
What does the U19 cooperative agreement mechanism imply?
A U19 cooperative agreement generally indicates a more hands-on partnership between NIH and funded research teams than a standard research grant. NIH program staff are expected to have substantial involvement in coordination, oversight, and alignment of activities across projects, with an emphasis on cooperation, shared goals, and integration across scientific components.
What is the funding activity category for this opportunity?
The funding activity category is health.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and CFDA 93.856 (Microbiology and Infectious Diseases Research).
How much funding was estimated to be available under this announcement?
The announcement listed an estimated total of about $3,000,000 in available funding.
What was the award ceiling listed for this opportunity?
The award ceiling listed was $500,000.
Was cost sharing or matching required?
No. The announcement stated there was no cost sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of receiving an award.
When was the FOA posted?
The FOA was posted on April 16, 2015.
What was the application deadline?
The application deadline was June 24, 2015.
Is this opportunity still open for applications?
No. The dates provided indicate this specific announcement cycle has closed, and the opportunity was later archived on July 25, 2015.
Even though it is archived, what does this opportunity represent in terms of NIH funding priorities?
It is representative of NIH center-style efforts aimed at accelerating progress in understanding protective and curative immune responses relevant to vaccine development, immunotherapies, and strategies to prevent chronic HCV infection, using coordinated multi-project teams under a cooperative agreement model.
Who was eligible to apply?
Eligibility was broad and included many types of U.S.-based organizations, such as public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); small businesses; for-profit entities (other than small businesses); and various government bodies (including state, county, city/township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and federally recognized Native American tribal governments).
Were any specific institution types explicitly included as eligible?
Yes. The announcement explicitly included HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also included faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are foreign institutions eligible to apply directly?
No. Foreign institutions and non-U.S. components of U.S. organizations were not eligible to apply.
Are any foreign activities or collaborations allowed under this opportunity?
Yes. Foreign components (as defined under NIH policy) were allowed. This typically means a U.S. applicant could include certain foreign collaborations or activities if justified and permitted under NIH rules.
Where can applicants find the official FOA text and historical details?
The official announcement page provided by NIH is: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-025.html
Who was listed for help with access or linking issues to the FOA page?
NIH indicated contact support via the NIH Office of Extramural Research (OER) webmaster email for access or linking issues.
What is the overall program emphasis in terms of how work should be conducted?
The emphasis is on cooperative, center-driven work that integrates multiple complementary projects, encourages shared resources and data, and coordinates efforts to produce an evidence-based understanding of what successful immunity to HCV looks like for prevention of infection and for achieving viral clearance.
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