Opportunity Information: Apply for RFA HG 15 027
Apply for RFA HG 15 027
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "High Quality Human and Non Human Primate Genome Sequences (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jun 2, 2015 and posted on Jun 2, 2015.
- Applicants must submit their applications by Aug 25, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Private institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH, through the National Human Genome Research Institute (NHGRI), offered this cooperative agreement opportunity to build and release a set of very high quality reference genome assemblies as a broadly usable community resource. The main goal was to generate, over a three year period, substantially improved reference assemblies that go beyond what was available at the time, both by complementing existing references and by correcting their known limitations (such as gaps, misassemblies, difficult repetitive regions, and incomplete representation of structural variation). The project scope targeted two deliverables: a collection of 25 to 50 human genome assemblies and a smaller set of 10 to 12 assemblies from selected non human primate species. In practical terms, the funding was meant to support large scale, production oriented genome assembly work that would yield high confidence, reference grade sequences suitable for widespread downstream use in research.
The award mechanism was a U24 cooperative agreement, which signals that the work was expected to be done in close partnership with NHGRI rather than as a fully investigator driven grant with minimal federal involvement. Under a cooperative agreement, the NIH program staff typically take an active role in shaping milestones, coordinating with other related efforts, and helping ensure the final outputs meet community standards for quality and accessibility. The emphasis on producing a "community resource" also implies expectations around rapid and broad data release, consistent formatting and documentation, and ongoing coordination so that the outputs can be easily adopted by genome scientists, tool developers, and biomedical researchers.
This funding opportunity (RFA-HG-15-027) was categorized as discretionary funding and aligned with the health-related mission of NIH. NHGRI anticipated making two awards, with an estimated total funding amount of about $2,000,000. There was no cost sharing or matching requirement, meaning applicants were not required to provide non-federal funds to receive the award. The announcement was posted on June 2, 2015, and the application due date (original and current) was August 25, 2015, with an archive date of September 25, 2015, indicating it was a time-limited solicitation rather than an open-ended program.
Eligibility was broad across U.S.-based organizations and included public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses), and state governments, as well as certain tribal governments and tribal organizations. The eligibility list also explicitly included several categories of minority-serving institutions and other specialized institutional types, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, and Tribally Controlled Colleges and Universities (TCCUs), along with U.S. territories or possessions and regional organizations. Foreign institutions (non-U.S. entities) were not eligible to apply as prime applicants, although non-domestic components of U.S. organizations were allowed, and foreign components as defined by NIH policy were permitted. This structure is typical of NIH programs that want the main awardee to be U.S.-based while still allowing international collaboration when it is scientifically or operationally necessary.
From a scientific and resource perspective, the focus on both human and non human primate genomes reflects two complementary needs. For human genomics, multiple high quality assemblies help capture diversity and improve interpretation of variation, especially in complex genomic regions where earlier references were incomplete or biased. For non human primates, high quality reference genomes support comparative genomics, evolutionary biology, and biomedical research that relies on primate models, with better assemblies improving gene annotation, orthology mapping, and cross-species analyses. By explicitly calling for "very high quality" assemblies and specifying concrete assembly counts, NHGRI was signaling a production-level effort with clear throughput targets and quality expectations, not just method development.
Administrative details include the CFDA number 93.172 (Human Genome Research) and NIH contact support through the NIH Office of Extramural Research (OER) webmaster for technical issues accessing the announcement or links. The full announcement was referenced through the NIH grants guide URL provided in the opportunity, where applicants would have found the detailed requirements, expected milestones, data sharing policies, and any specific standards for assembly quality, validation, and public release that typically accompany NHGRI community resource initiatives.
Frequently Asked Questions (FAQs)
What is this NIH/NHGRI funding opportunity trying to accomplish?
This cooperative agreement opportunity (RFA-HG-15-027) was intended to build and publicly release a set of very high quality reference genome assemblies as a broadly usable community resource. The project was designed as a production-oriented effort to generate substantially improved reference assemblies that complement existing references and correct known limitations such as gaps, misassemblies, difficult repetitive regions, and incomplete representation of structural variation.
What were the main deliverables expected from the project?
The scope targeted two major deliverables: (1) a collection of 25 to 50 human genome assemblies, and (2) a smaller set of 10 to 12 assemblies from selected non-human primate species.
How long was the project period expected to be?
The goal was to generate the improved reference assemblies over a three-year period.
What type of funding mechanism was used?
The award mechanism was a U24 cooperative agreement.
What does a U24 cooperative agreement imply about NIH involvement?
A U24 cooperative agreement generally indicates substantial programmatic involvement by NIH staff. In this opportunity, NHGRI expected close partnership, with NIH program staff typically helping shape milestones, coordinating with related efforts, and working to ensure the final outputs meet community standards for quality and accessibility.
What does it mean that the outputs are intended as a "community resource"?
The emphasis on a community resource implies expectations around rapid and broad data release, consistent formatting and documentation, and ongoing coordination so the outputs can be easily adopted by genome scientists, tool developers, and biomedical researchers.
What kinds of technical improvements were these reference assemblies expected to address?
The assemblies were expected to go beyond what was available at the time by complementing existing references and correcting known limitations, including gaps, misassemblies, difficult repetitive regions, and incomplete representation of structural variation.
Why did the opportunity include both human and non-human primate genomes?
For human genomics, multiple high quality assemblies help capture diversity and improve interpretation of variation, particularly in complex regions where earlier references were incomplete or biased. For non-human primates, high quality reference genomes support comparative genomics, evolutionary biology, and biomedical research that relies on primate models, improving gene annotation, orthology mapping, and cross-species analyses.
Was this opportunity focused on method development or production-scale assembly?
Based on the stated goals and the specified assembly counts, NHGRI signaled a production-level, large-scale genome assembly effort with clear throughput targets and quality expectations, rather than a primarily method-development project.
How many awards did NHGRI anticipate making?
NHGRI anticipated making two awards.
What was the estimated total funding amount?
The estimated total funding amount was about $2,000,000.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement, so applicants were not required to provide non-federal funds to receive the award.
How was this funding opportunity categorized?
The opportunity was categorized as discretionary funding and aligned with NIH's health-related mission.
When was the announcement posted?
The announcement was posted on June 2, 2015.
What was the application due date?
The application due date (original and current) was August 25, 2015.
What does the archive date indicate?
The archive date was September 25, 2015, indicating this was a time-limited solicitation rather than an open-ended program.
Who was eligible to apply as a prime applicant?
Eligibility was broad across U.S.-based organizations and included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses), state governments, certain tribal governments and tribal organizations, U.S. territories or possessions, and regional organizations.
Were minority-serving institutions explicitly included in the eligibility list?
Yes. The eligibility list explicitly included several categories of minority-serving and specialized institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, and Tribally Controlled Colleges and Universities (TCCUs).
Could a foreign (non-U.S.) institution apply as the prime applicant?
No. Foreign institutions (non-U.S. entities) were not eligible to apply as prime applicants.
Are foreign or non-domestic components allowed in any way?
Yes. Non-domestic components of U.S. organizations were allowed, and foreign components as defined by NIH policy were permitted, which supports international collaboration while keeping the main awardee U.S.-based.
What was the CFDA number associated with this opportunity?
The CFDA number listed was 93.172 (Human Genome Research).
Where would applicants have found the full, detailed requirements?
The full announcement was referenced through the NIH grants guide URL provided in the opportunity. That is where applicants would have found detailed requirements such as expected milestones, data sharing policies, and any specific standards for assembly quality, validation, and public release typically associated with NHGRI community resource initiatives.
Who was listed as a point of contact for technical issues accessing the announcement?
NIH contact support for technical issues accessing the announcement or links was through the NIH Office of Extramural Research (OER) webmaster.
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