Opportunity Information: Apply for PAR 14 284
Apply for PAR 14 284
- The National Institutes of Health in the education food and nutrition health income security and social services sector is offering a public funding opportunity titled "High Throughput Screening (HTS) to Discover Chemical Probes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Jul 17, 2014 and posted on Jul 17, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses Native American tribal governments (Federally recognized) County governments Special district governments City or township governments Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH funding opportunity PAR-14-284, titled "High Throughput Screening (HTS) to Discover Chemical Probes (R01)," supports research projects that use high throughput screening to discover and develop small-molecule chemical probes. The central idea is that investigators should partner with an established HTS facility (academic, nonprofit, or commercial) that already has the staff, equipment, and practical experience to run HTS-ready assays. NIH is looking for projects that can rapidly test large numbers of compounds, identify promising hits, and move those hits toward well-characterized chemical probes that researchers can use to study biology and disease.
The scientific goals emphasized by the announcement fall into two related areas. First, it aims to accelerate the discovery and development of novel small molecules that can be used as tools for studying potential disease treatments aligned with the missions of participating NIH Institutes and Centers. These chemical probes are not simply "drug candidates" in a vague sense; they are intended to be reliable research tools that can modulate a biological target or pathway so scientists can test hypotheses, map mechanisms, and explore therapeutic concepts. Second, the FOA encourages work that discovers new biological targets or validates and strengthens the evidence for existing targets, with the broader objective of improving understanding of disease mechanisms. Priority is placed on studies that offer genuinely new insight into meaningful disease targets and biological processes, rather than routine screening exercises that do not substantially advance understanding.
Mechanistically, this FOA is built around collaboration and readiness for HTS execution. Applicants are expected to bring forward an assay that is appropriate for screening at scale (or have a credible plan to make it HTS-ready) and to work closely with an HTS partner capable of implementing that assay in a robust, reproducible way. The emphasis on an experienced screening facility signals that NIH wants proposals grounded in practical screening realities, such as assay performance, controls, data quality, hit validation strategies, and the ability to progress from initial hits to more refined probe candidates. Projects are expected to connect screening outcomes back to biological questions about disease targets and pathways, rather than treating screening as an end in itself.
Administratively, this is a discretionary grant using the NIH R01 funding mechanism. It was posted and created on July 17, 2014, with an original and final closing date of September 7, 2017, and an archive date of October 8, 2017, meaning it is no longer active as a current submission opportunity in that specific form. The FOA explicitly states there is no cost sharing or matching requirement, which typically means applicants do not need to commit institutional funds as a condition of award beyond standard expectations for project support and compliance.
Eligible applicants are broad and include many types of U.S. and non-U.S. organizations. Domestic eligibility includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, independent school districts, and multiple levels of government (state, county, city/township, special district governments), as well as public housing authorities and tribal governments and tribal organizations. The eligibility language also highlights a range of mission- or population-focused institutions and organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions, along with faith-based and community-based organizations where applicable. Importantly, non-domestic entities (foreign organizations and foreign institutions) are eligible to apply, non-domestic components of U.S. organizations may apply, and foreign components are allowed as defined by NIH policy, which opens the door to international participation when scientifically justified.
The opportunity is aligned with a wide set of NIH research areas reflected in the CFDA listings provided, spanning deafness and communication disorders (93.173), mental health (93.242), alcohol research (93.273), drug abuse and addiction (93.279), cancer detection/diagnosis and treatment research (93.394, 93.395), arthritis and musculoskeletal/skin diseases (93.846), diabetes/digestive/kidney diseases (93.847), neurosciences and neurological disorders (93.853), child health and human development (93.865), aging research (93.866), and vision research (93.867). This breadth reinforces that the FOA is not tied to a single disease area; instead, it is a platform for applying HTS-driven probe discovery to many kinds of medically relevant targets and mechanisms, as long as the project meaningfully advances insight into disease biology and aligns with participating NIH institute missions.
For reference and full details, the announcement pointed applicants to the NIH Guide page at http://grants.nih.gov/grants/guide/pa-files/PAR-14-284.html and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): NIH PAR-14-284 - High Throughput Screening (HTS) to Discover Chemical Probes (R01)
What is PAR-14-284?
PAR-14-284 is an NIH funding opportunity titled "High Throughput Screening (HTS) to Discover Chemical Probes (R01)." It supports research projects that use high throughput screening approaches to discover and develop small-molecule chemical probes.
What is the main purpose of this funding opportunity?
The main purpose is to accelerate the discovery and development of well-characterized small-molecule chemical probes that researchers can use to study biology and disease. NIH is looking for projects that can screen large numbers of compounds, identify promising hits, and advance those hits toward reliable probe-quality molecules that help answer meaningful biological questions.
What kinds of projects does this FOA emphasize?
The FOA emphasizes projects that (1) discover and develop novel small molecules as research tools aligned with participating NIH Institute and Center missions, and (2) discover new biological targets or strengthen/validate evidence for existing targets in ways that improve understanding of disease mechanisms.
Are these probes intended to be drug candidates?
The focus is on chemical probes as reliable research tools, not on "drug candidates" in a general or vague sense. The probes are meant to modulate a biological target or pathway so researchers can test hypotheses, investigate mechanisms, and explore therapeutic concepts in a rigorous way.
Does the FOA require high throughput screening (HTS) capability?
Yes. The FOA is centered on HTS execution and expects projects to be positioned to rapidly test large numbers of compounds using an HTS-ready assay (or a credible plan to make the assay HTS-ready).
Do applicants need to partner with an HTS facility?
Yes. A central expectation is that investigators partner with an established HTS facility (academic, nonprofit, or commercial) that already has the staff, equipment, and hands-on experience to run HTS-ready assays.
What does NIH mean by an "established" HTS facility?
Based on the announcement description, an established HTS facility is one that already has the practical screening infrastructure in place, including experienced staff, appropriate screening equipment, and the real-world experience needed to implement robust, reproducible, HTS-scale assays.
What aspects of screening readiness does NIH expect proposals to address?
The FOA highlights practical HTS realities such as assay performance, controls, data quality, hit validation strategies, and the ability to progress from initial screening hits to more refined chemical probe candidates. It also stresses that screening outcomes should tie back to biological questions about disease targets and pathways.
Is routine screening without broader biological impact competitive under this FOA?
The FOA places priority on studies that provide genuinely new insight into meaningful disease targets and biological processes. It discourages routine screening efforts that do not substantially advance understanding of disease biology.
What grant mechanism supports this opportunity?
This opportunity uses the NIH R01 funding mechanism and is described as a discretionary grant.
Is this funding opportunity still open?
No. The FOA was posted/created on July 17, 2014, had an original and final closing date of September 7, 2017, and an archive date of October 8, 2017. That means it is no longer active as a current submission opportunity in that specific form.
Is cost sharing or matching required?
No. The FOA explicitly states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Domestic applicants may include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, independent school districts, and various government entities (state, county, city/township, special district), as well as public housing authorities and tribal governments and tribal organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility language indicates that non-domestic entities (foreign organizations and foreign institutions) are eligible to apply. It also notes that non-domestic components of U.S. organizations may apply, and foreign components are allowed as defined by NIH policy.
Are certain institution types specifically highlighted as eligible?
Yes. The eligibility language highlights a range of mission- or population-focused institutions and organizations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions. Faith-based and community-based organizations are also referenced where applicable.
Does the FOA focus on a single disease area?
No. The FOA is positioned as a platform for applying HTS-driven probe discovery across many medically relevant targets and mechanisms, provided projects align with participating NIH Institute missions and meaningfully advance insight into disease biology.
What NIH research areas are associated with this opportunity?
The announcement references a broad set of CFDA listings covering multiple areas, including deafness and communication disorders (93.173), mental health (93.242), alcohol research (93.273), drug abuse and addiction (93.279), cancer detection/diagnosis and treatment research (93.394 and 93.395), arthritis and musculoskeletal/skin diseases (93.846), diabetes/digestive/kidney diseases (93.847), neurosciences and neurological disorders (93.853), child health and human development (93.865), aging research (93.866), and vision research (93.867).
Where can applicants find the original NIH Guide announcement?
The FOA pointed to the NIH Guide page at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-284.html
Who should be contacted for technical issues accessing or linking to the FOA page?
The announcement provided the NIH Office of Extramural Research (OER) webmaster contact for access or linking issues: FBOWebmaster@OD.NIH.GOV
Browse more opportunities from the same category: Education Food and Nutrition Health Income Security and Social Services
Next opportunity: Tracy Ecosystem Restoration Phase II and Lower Truckee River Restoration
Previous opportunity: High Throughput Screening (HTS) to Discover Chemical Probes (R21)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 14 284
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 14 284) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Big Data to Knowledge (BD2K) Enhancing Diversity in Biomedical Data Science (R25) Apply for RFA MD 15 005 Funding Number: RFA MD 15 005 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: $200,000 |
| Advancing Mechanistic Probiotic/Prebiotic and Human Microbiome Research (R01) Apply for PA 15 135 Funding Number: PA 15 135 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Exploratory/Developmental Clinical Research Grants in Obesity (R21) Apply for PA 15 163 Funding Number: PA 15 163 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: $200,000 |
| Diet and Physical Activity Assessment Methodology (R01) Apply for PAR 15 170 Funding Number: PAR 15 170 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Diet and Physical Activity Assessment Methodology (R21) Apply for PAR 15 171 Funding Number: PAR 15 171 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: $200,000 |
| Opportunities for Collaborative Research at the NIH Clinical Center (U01) Apply for PAR 15 287 Funding Number: PAR 15 287 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: $500,000 |
| Improving Diet and Physical Activity Assessment (R21) Apply for PAR 06 103 Funding Number: PAR 06 103 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: $200,000 |
| Research on Improving Health Care for Obese Patients (R01) Apply for PA 07 013 Funding Number: PA 07 013 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Developmental Biology and Regeneration of the Liver (R01) Apply for PA 07 026 Funding Number: PA 07 026 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| School based Interventions to Prevent Obesity (R01) Apply for PA 07 180 Funding Number: PA 07 180 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Improving Diet and Physical Activity Assessment (R01) Apply for PAR 07 259 Funding Number: PAR 07 259 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Research On Ethical Issues In Human Subjects Research (R01) Apply for PA 07 277 Funding Number: PA 07 277 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Diet Composition and Energy Balance (R01) Apply for PA 07 218 Funding Number: PA 07 218 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Lymphatic Biology in Health and Disease (R01) Apply for PAR 07 420 Funding Number: PAR 07 420 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Human Pluripotent Stem Cell (hPSC) Research Using Non Embryonic Sources (R01) Apply for PA 08 043 Funding Number: PA 08 043 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Safe and Effective Instruments and Devices for use in the Neonatal Intensive Care Units (SBIR R43) Apply for RFA HD 09 017 Funding Number: RFA HD 09 017 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Improving Diet and Physical Activity Assessment (R01) Apply for PAR 09 224 Funding Number: PAR 09 224 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Improving Diet and Physical Activity Assessment (R21) Apply for PAR 09 225 Funding Number: PAR 09 225 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: $200,000 |
| Mechanisms, Models, Measurement, and Management in Pain Research (R01) Apply for PA 10 006 Funding Number: PA 10 006 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Obesity Policy Research Evaluation and Measures (R01) Apply for PA 10 027 Funding Number: PA 10 027 Agency: National Institutes of Health Category: Education Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 14 284", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.