Opportunity Information: Apply for PAR 13 134
Apply for PAR 13 134
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "High Throughput Screening (HTS) to Discover Chemical Probes (X01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.350 National Center for Advancing Translational Sciences 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Mar 6, 2013 and posted on Mar 6, 2013.
- Applicants must submit their applications by Dec 4, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Private institutions of higher education Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The High Throughput Screening (HTS) to Discover Chemical Probes (X01) opportunity (Funding Opportunity Number PAR-13-134) is a National Institutes of Health resource access program designed to speed up the discovery and development of new chemical probes. These probes are small molecules that researchers can use as practical tools in the lab to better understand how biological systems work, how diseases develop, and which molecular targets might be worth pursuing for future therapeutic research. Rather than focusing on funding a traditional investigator-driven research project from end to end, this announcement is structured to encourage investigators who have a promising assay or biological question to partner with an established, funded HTS and chemical probe discovery facility. In other words, NIH is trying to connect strong biological ideas and assays with the specialized infrastructure and expertise needed to run large-scale screening and early probe optimization.
The core goal is to generate high-quality chemical probes that the wider research community can use to explore biology and disease mechanisms. NIH highlights two major research outcomes it wants to stimulate. First, it seeks the discovery and development of novel small molecules that can be used as research tools in areas related to disease treatment and biomedical priorities aligned with the missions of the participating NIH Institutes and Centers. Second, it aims to support the discovery and/or validation of new biological targets, meaning that the screening effort can help confirm whether a particular protein, pathway, or cellular process is genuinely relevant to a disease mechanism and worth deeper study. A key emphasis is placed on assays that can deliver new insight into important disease targets and biological processes, so proposals are expected to go beyond routine screening and instead demonstrate that the assay is meaningful, informative, and positioned to answer an important question in health and disease.
This opportunity is categorized as a discretionary grant program using the X01 activity code, which typically signals access to NIH-supported resources rather than a standard direct-cost research grant mechanism. It is associated with multiple NIH-related CFDA numbers reflecting the breadth of participating scientific missions, including mental health research (93.242), alcohol research programs (93.273), drug abuse and addiction research programs (93.279), the National Center for Advancing Translational Sciences (93.350), and child health and human development extramural research (93.865). There is no cost sharing or matching requirement, which reduces financial barriers for applicants and reinforces that the focus is on enabling access to specialized screening and probe discovery capabilities.
Eligibility is broad and includes many types of domestic and international organizations. Eligible applicants include nonprofit organizations (both with and without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, public and private institutions of higher education, public and state-controlled institutions of higher education, independent school districts, and public housing authorities or Indian housing authorities. The announcement also explicitly welcomes a wide range of mission-serving and community-based entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations, regional organizations, and eligible federal government agencies. Importantly, non-U.S. entities and foreign institutions are eligible to apply, foreign components are allowed under NIH policy, and non-U.S. components of U.S. organizations can participate, signaling NIH interest in attracting strong assays and biological problems regardless of geography.
The opportunity was posted and created on March 6, 2013, with an original and current closing date of December 4, 2015, and an archive date of January 4, 2016. The sponsoring agency is the National Institutes of Health. The full announcement was made available through the NIH Grants Guide (linked in the source material), and NIH’s Office of Extramural Research provides contact support for applicants who have technical trouble accessing or linking to the official funding announcement.
Frequently Asked Questions (FAQs)
What is the High Throughput Screening (HTS) to Discover Chemical Probes (X01) opportunity?
It is a National Institutes of Health (NIH) resource access program designed to speed up the discovery and development of new chemical probes through high throughput screening (HTS). The program is listed as Funding Opportunity Number PAR-13-134 and uses the X01 activity code.
What is the purpose of this opportunity?
The purpose is to generate high-quality chemical probes (small molecules) that can be used broadly by the research community to study biology and disease mechanisms. The program is meant to connect promising assays and biological questions with specialized HTS and early probe discovery capabilities.
What is a chemical probe in the context of this program?
A chemical probe is a small molecule that researchers can use as a practical laboratory tool to better understand how biological systems work, how diseases develop, and which molecular targets may be promising for future therapeutic research.
Is this a traditional research grant that funds an entire project end to end?
No. The announcement is structured as a resource access program rather than a traditional investigator-driven research project mechanism. It is designed to encourage investigators with strong assays or biological questions to partner with an established, funded HTS and chemical probe discovery facility.
What kinds of projects or starting points does NIH want to support through this opportunity?
The opportunity emphasizes investigators who have a promising assay or a strong biological question and who can benefit from partnering with a specialized HTS and probe discovery facility to run large-scale screening and early probe optimization.
What outcomes is NIH trying to stimulate through this program?
NIH highlights two major outcomes: (1) discovery and development of novel small molecules that can be used as research tools in areas related to disease treatment and other biomedical priorities aligned with participating NIH Institutes and Centers, and (2) discovery and/or validation of new biological targets, such as confirming whether a protein, pathway, or cellular process is relevant to a disease mechanism and worth deeper study.
What does NIH mean by discovery and/or validation of new biological targets?
The screening effort can help confirm whether a specific protein, pathway, or cellular process is genuinely relevant to a disease mechanism and therefore a worthwhile target for deeper research.
What is the program looking for in an assay?
A key emphasis is on assays that can deliver new insight into important disease targets and biological processes. The expectation is that proposals go beyond routine screening and show that the assay is meaningful, informative, and positioned to answer an important question in health and disease.
What does the X01 activity code indicate for this opportunity?
The X01 activity code typically signals access to NIH-supported resources rather than a standard direct-cost research grant mechanism. In this case, it reflects a model focused on enabling access to specialized screening and probe discovery infrastructure and expertise.
Is cost sharing or matching required?
No. The opportunity states that there is no cost sharing or matching requirement.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple NIH-related CFDA numbers, including 93.242 (mental health research), 93.273 (alcohol research programs), 93.279 (drug abuse and addiction research programs), 93.350 (National Center for Advancing Translational Sciences), and 93.865 (child health and human development extramural research).
Who is eligible to apply?
Eligibility is broad and includes many domestic and international organizations. Eligible applicants include nonprofit organizations (with and without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, public and private institutions of higher education (including public and state-controlled institutions), independent school districts, and public housing authorities or Indian housing authorities.
Are minority-serving institutions and community-based organizations included in the eligibility list?
Yes. The announcement explicitly welcomes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations, regional organizations, and eligible federal government agencies.
Are non-U.S. organizations eligible to apply?
Yes. Non-U.S. entities and foreign institutions are eligible to apply.
Are foreign components allowed if the applicant is a U.S. organization?
Yes. Foreign components are allowed under NIH policy, and non-U.S. components of U.S. organizations can participate.
What is the funding opportunity number?
The funding opportunity number is PAR-13-134.
When was this opportunity posted?
The opportunity was posted (and created) on March 6, 2013.
What were the closing date and archive date for this opportunity?
The original and current closing date listed is December 4, 2015. The archive date is January 4, 2016.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide (as referenced in the source material).
Who can be contacted for help if there are technical problems accessing the official announcement?
NIH's Office of Extramural Research provides contact support for applicants who have technical trouble accessing or linking to the official funding announcement.
What is the main collaboration model encouraged by this announcement?
The model encourages investigators with a strong assay or biological question to partner with an established, funded HTS and chemical probe discovery facility so the project can leverage specialized infrastructure and expertise for large-scale screening and early probe optimization.
What is the overarching goal for the broader scientific community?
The overarching goal is to generate high-quality chemical probes that the wider research community can use to explore biology and disease mechanisms.
Browse more opportunities from the same category: Education Health Income Security and Social Services
Next opportunity: High Throughput Screening (HTS) to Discover Chemical Probes (R03)
Previous opportunity: Advancing Eating Disorders Research through Dimensional Studies of Biology and Behavior (R01)
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 13 134) also looked into and applied for these:
| Funding Opportunity |
|---|
| High Throughput Screening (HTS) to Discover Chemical Probes (R03) Apply for PAR 13 135 Funding Number: PAR 13 135 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $50,000 |
| Short Courses on Innovative Methodologies in the Behavioral and Social Sciences (R25) Apply for RFA OD 13 009 Funding Number: RFA OD 13 009 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
| Pre application Opportunities for Collaborative Research at the NIH Clinical Center (X02) Apply for PAR 13 357 Funding Number: PAR 13 357 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Opportunities for Collaborative Research at the NIH Clinical Center (U01) Apply for PAR 13 358 Funding Number: PAR 13 358 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health Determinants and Consequences of Violence and its Prevention, Particularly Firearm Violence (R03) Apply for PA 13 368 Funding Number: PA 13 368 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health Determinants and Consequences of Violence and its Prevention, Particularly Firearm Violence (R01) Apply for PA 13 363 Funding Number: PA 13 363 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health Determinants and Consequences of Violence and its Prevention, Particularly Firearm Violence (R21) Apply for PA 13 369 Funding Number: PA 13 369 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
| Mobile Health Technology and Outcomes in Low and Middle Income Countries (R21) Apply for PAR 14 028 Funding Number: PAR 14 028 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $125,000 |
| U.S South Africa Program for Collaborative Biomedical Research (R01) Apply for RFA AI 14 009 Funding Number: RFA AI 14 009 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $350,000 |
| U.S South Africa Program for Collaborative Biomedical Research (R21) Apply for RFA AI 14 010 Funding Number: RFA AI 14 010 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
| Mentored Research Scientist Development Award (Parent K01) Apply for PA 14 044 Funding Number: PA 14 044 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Direct Phase II SBIR Grants to Support Biomedical Technology Development Apply for PAR 14 088 Funding Number: PAR 14 088 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Design and Development of Novel Technologies for Healthy Independent Living (R21) Apply for PAR 14 119 Funding Number: PAR 14 119 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
| Technologies for Healthy Independent Living (R01) Apply for PAR 14 118 Funding Number: PAR 14 118 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (R25) Apply for RFA NS 14 010 Funding Number: RFA NS 14 010 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for NIH Industry Program Discovering Pediatric New Therapeutic Uses for Existing Molecules (UH2/UH3) Apply for PAR 14 210 Funding Number: PAR 14 210 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for NIH Industry Program Discovering New Therapeutic Uses for Existing Molecules (UH3) Apply for PAR 14 211 Funding Number: PAR 14 211 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for NIH Industry Program Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3) Apply for PAR 14 212 Funding Number: PAR 14 212 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Pre application for the NIH Industry Program Discovering New Therapeutic Uses for Existing Molecules (X02) Apply for PAR 14 213 Funding Number: PAR 14 213 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Research on Chronic Overlapping Pain Conditions (R21) Apply for PA 14 243 Funding Number: PA 14 243 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
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