Human Biospecimen Resources for Aging Research (R03) | Apply Online

Opportunity Summary:

The Human Biospecimen Resources for Aging Research (R03) opportunity (Funding Opportunity Number PA 06 443) is an NIH program announcement designed to help researchers make practical use of already-existing human biospecimen collections for aging-related studies. Rather than funding the creation of new specimen banks, the main goal is to spread awareness of biospecimen resources that already exist and to encourage independent investigators to pursue pilot projects by partnering or otherwise coordinating with the established studies that collected those specimens in the first place. The participating collections and study websites are organized through the National Institute on Aging (NIA) Virtual Repository, which serves as a central entry point for identifying what biospecimens are available and which cohorts or studies maintain them.

Scientifically, the announcement emphasizes aging research that combines biomarker work with broader, real-world phenotypic information. NIA highlights interests that connect biological measures (for example, molecular, genetic, proteomic, metabolic, inflammatory, endocrine, or other biomarker analyses) with questions about normal aging, common age-associated diseases, and the kinds of behavioral and psychosocial data often captured in longitudinal cohorts. The intent is to support research that can take advantage of rich existing datasets linked to stored samples, allowing investigators to explore new hypotheses or test feasibility before moving toward larger-scale projects. In other words, this R03 is positioned as a pilot and exploratory pathway meant to open up new directions, validate methods, and generate preliminary findings that could justify subsequent, more extensive funding.

The funding mechanism is the NIH R03 small grant, and the announcement specifies an award ceiling of $50,000. The activity category is health, under CFDA 93.866 (Aging Research), and there is no cost-sharing or matching requirement. The overall structure reflects a small, targeted investment meant to catalyze innovative secondary use of valuable biospecimen resources, especially where the major costs relate to assays, sample handling fees, data access arrangements, and focused analytic work rather than building new infrastructure.

Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), state and local governments (including county and city/township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, and eligible federal agencies. Tribal governments and tribal organizations are also included. Faith-based and community-based organizations may apply as well. A key restriction is that foreign institutions are not eligible to apply. Applicants are allowed to submit more than one application as long as each proposed project is scientifically distinct.

A notable application requirement is documentation of access: applicants must include a letter from the principal investigator(s) of the study or studies that control the biospecimens being requested. That letter must confirm that the biospecimens needed for the proposed project are available. This requirement reinforces that the program expects investigators to have already initiated coordination with the cohort or repository managers and to have a credible plan for obtaining the materials and any associated data necessary to complete the pilot study.

Administratively, the opportunity was posted May 31, 2006 (with a later creation date listed as December 5, 2008), used multiple receipt dates, and had a last listed closing date of September 7, 2009, with an archive date of October 7, 2009. The sponsoring agency is the National Institutes of Health, with NIA as the driving institute behind the biospecimen repository focus. The full announcement was available through the NIH grants guide at the provided link, and NIH’s Office of Extramural Research webmaster contact is listed for technical access issues.

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