Opportunity Information: Apply for RFA AG 14 012
Apply for RFA AG 14 012
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Human Cell Reprogramming for Functional Genetics of Alzheimers Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 7, 2013 and posted on Aug 7, 2013.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: County governments Independent school districts Special district governments For profit organizations other than small businesses Public and State controlled institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) offered this discretionary grant opportunity, titled "Human Cell Reprogramming for Functional Genetics of Alzheimers Disease (R01)" (Funding Opportunity Number RFA-AG-14-012), to support research that connects Alzheimers disease genetics to measurable cellular effects in human neural cell types. The central purpose of the announcement is to establish clear functional genotype-phenotype relationships for (1) genes already known to cause Alzheimers disease, (2) genes or specific genetic variants suspected of changing Alzheimers risk (including candidates emerging from GWAS and related genetic studies), and (3) genetic or biological modifiers that influence disease pathways. The program emphasizes using human pluripotent stem cell (hPSC) platforms, including induced pluripotent stem cells and related reprogramming methods, together with genome editing approaches to create defined genetic models and then evaluate how those variants change neuronal and glial biology.
At a scientific level, the opportunity is aimed at moving beyond statistical genetic associations and toward functional evidence in relevant human cell contexts. Applicants were expected to use hPSC-derived neurons and glial cells to test how specific risk genes and variants affect cellular phenotypes tied to Alzheimers disease mechanisms. The FOA frames this as a way to uncover new gene networks, cellular pathways, and molecular targets that contribute to disease etiology. In practical terms, the work envisioned by this announcement would typically involve generating isogenic cell lines that differ only at a variant of interest, differentiating those lines into specific neural cell types, and then applying cellular, molecular, and functional assays to determine the downstream consequences of the genetic change. The broader goal is to identify actionable biology: networks and targets that explain how genetic risk translates into pathological processes and that could ultimately guide therapeutic strategies.
Administratively, this was an NIH grant using the R01 research project grant mechanism under the Health funding activity category, with CFDA number 93.866 (Aging Research). The FOA did not require cost sharing or matching. The estimated total program funding was $1,000,000, and the award ceiling was listed as $250,000. The opportunity was posted and created on August 7, 2013, with an original and current closing date of January 7, 2014, and it was archived on February 7, 2014, indicating it is no longer open for submission.
Eligibility was broad and included a wide range of domestic and international applicant types. Eligible applicants encompassed state and local governments (including county, city or township, and special district governments), public housing authorities/Indian housing authorities, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), independent school districts, and Native American tribal organizations (both federally recognized and other than federally recognized). The FOA also explicitly noted additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. entities and foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were allowed, and foreign components as defined by NIH policy were permitted.
For reference and official details, NIH provided an additional information link to the full announcement at http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-012.html. NIH also listed the Office of Extramural Research (OER) webmaster contacts for technical issues accessing or linking to the funding announcement (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The opportunity is titled "Human Cell Reprogramming for Functional Genetics of Alzheimers Disease (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AG-14-012.
Which federal agency offered this grant?
This is a discretionary grant opportunity offered by the National Institutes of Health (NIH).
What type of grant mechanism is used?
The announcement uses the NIH R01 research project grant mechanism.
What is the main scientific purpose of the FOA?
The central purpose is to connect Alzheimers disease genetics to measurable cellular effects in human neural cell types by establishing clear functional genotype-phenotype relationships.
What kinds of genetic targets does the FOA focus on?
The FOA emphasizes functional genotype-phenotype relationships for: (1) genes already known to cause Alzheimers disease, (2) genes or specific variants suspected of changing Alzheimers risk (including candidates from GWAS and related genetic studies), and (3) genetic or biological modifiers that influence disease pathways.
What research approach does the FOA emphasize?
The program emphasizes human pluripotent stem cell (hPSC) platforms, including induced pluripotent stem cells and related reprogramming methods, used together with genome editing approaches to create defined genetic models and evaluate how variants change neuronal and glial biology.
Why does the FOA emphasize human neural cell types?
The FOA is aimed at moving beyond statistical genetic associations by generating functional evidence in relevant human cell contexts, specifically in human neurons and glial cells derived from hPSC platforms.
What kinds of cell types are expected to be used in the proposed work?
Applicants were expected to use hPSC-derived neurons and glial cells to test how specific risk genes and variants affect cellular phenotypes tied to Alzheimers disease mechanisms.
What does the FOA mean by moving beyond genetic association studies?
It means going beyond statistical links between variants and disease risk (such as those identified through GWAS) and producing functional data that shows how specific genes or variants cause measurable cellular changes in relevant human neural cell types.
What is meant by a functional genotype-phenotype relationship in this context?
In this FOA, it refers to a clear link between a defined genetic change (genotype) and a measurable cellular effect (phenotype) in human neural cells, such as changes in neuronal or glial biology tied to Alzheimers disease mechanisms.
What kind of model systems are envisioned?
The announcement envisions using defined genetic models built on hPSC platforms, often involving genome editing and the creation of isogenic cell lines that differ only at a variant of interest.
What are isogenic cell lines and why are they relevant here?
As described in the FOA, isogenic cell lines are lines that differ only at the genetic variant of interest. They are relevant because they allow researchers to attribute observed cellular differences to the specific variant being tested.
What kinds of experiments are implied by the FOA?
The FOA describes work that would typically include generating isogenic cell lines, differentiating those lines into specific neural cell types (neurons and glia), and applying cellular, molecular, and functional assays to determine downstream consequences of the genetic change.
What is the broader goal of this research program?
The broader goal is to identify actionable biology: gene networks, cellular pathways, and molecular targets that explain how genetic risk translates into pathological processes and that could ultimately guide therapeutic strategies.
Does the FOA specify a funding activity category?
Yes. The funding activity category is Health.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.866, listed as Aging Research.
What is the estimated total program funding for this FOA?
The estimated total program funding is $1,000,000.
What is the award ceiling listed for this opportunity?
The award ceiling is $250,000.
Is cost sharing or matching required?
No. The FOA did not require cost sharing or matching.
When was the opportunity posted and created?
The opportunity was posted and created on August 7, 2013.
What was the application closing date?
The original and current closing date listed was January 7, 2014.
Is this FOA currently open for submissions?
No. The opportunity was archived on February 7, 2014, indicating it is no longer open for submission.
Who is eligible to apply?
Eligibility is broad and includes domestic and international applicants, including: state and local governments (including county, city or township, and special district governments), public housing authorities/Indian housing authorities, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), independent school districts, and Native American tribal organizations (federally recognized and other than federally recognized).
Are institutions such as HBCUs and Hispanic-serving institutions eligible?
Yes. The FOA explicitly noted eligibility for groups including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly included faith-based or community-based organizations among eligible applicants.
Are regional organizations and U.S. territories eligible?
Yes. The FOA explicitly included regional organizations and U.S. territories or possessions among eligible applicant types.
Are non-U.S. entities or foreign institutions eligible to apply?
Yes. The FOA stated that non-U.S. entities and foreign institutions were eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA stated that non-U.S. components of U.S. organizations were allowed.
Are foreign components permitted under NIH policy?
Yes. The FOA stated that foreign components (as defined by NIH policy) were permitted.
Where can applicants find the official full announcement?
NIH provided the full announcement here: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-012.html.
Who should be contacted for technical issues accessing or linking to the announcement?
NIH listed the Office of Extramural Research (OER) webmaster contact for technical issues: FBOWebmaster@OD.NIH.GOV.
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